Clinical trials: Sleep Disorder (Disorder)
Insomnia, Traumatic Brain Injury
Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury
The purpose of this clinical trial is to assess the relative efficacy of two non-pharmacological interventions for insomnia in Veterans suffering from chronic mild traumatic brain injury (mTBI).
- Trial name
- NCT03261674
- Testing
- CBT-I, ABT-I
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Periodic Breathing, Breathing-Related Sleep Disorder
Modified Adaptive Servoventilation (ASV) Compared to Conventional ASV
This study will determine if modified adaptive servoventilation (ASV) is as effective as the conventional ASV in treating periodic breathing.
- Trial name
- NCT01405313
- Testing
- Modified Adaptive Servoventilation Device, Conventional Adaptive Servoventilation device
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- ResMed
Insomnia
Transcranial Magnetic Stimulation for Treatment of Insomnia
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that has been approved as a treatment of depression in patients that have not responded to a trial of one antidepressant medication.
- Trial name
- TMSI (NCT02196025)
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Florida
Attention Deficit Disorder With Hyperactivity, Behavioral Insomnia of Childhood
Effects of Evening Dose of Immediate Release Methylphenidate on Sleep in Children With ADHD
Over 10% of children in the United States are diagnosed with ADHD, and nearly half of these children have moderate to severe impairments in sleep, further exacerbating their already impaired academic, emotional and social…
- Trial name
- NCT02638168
- Testing
- Immediate Release Methylphenidate
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Falls, Balance
Toileting at Night in Older Adults: Light to Maximize Balance, Minimize Insomnia
To examine the change in balance that occurs in older individuals when exposed to different colored lights at night.
- Conditions
- Falls, Balance, Insomnia, Aging
- Trial name
- NCT01350505
- Testing
- White light exposure, Dim white light exposure, Very dim white light exposure
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Insulin Resistance, Obesity
Metabolic Effects of Sleep Extension in People With Obesity
This study is designed to determine the impact of extending sleep duration on glucose metabolism in people with obesity. Half of the participants will be instructed to increase their time-in-bed in order to achieve >7h…
- Trial name
- NCT03594994
- Testing
- Sleep extension
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Sleep Disorders
Effect of High Rebound Mattress Toppers on Sleep and Sleep-Related Symptoms
The purpose of the study is to evaluate effects of high rebound mattress toppers (i.e., airweave®) on sleep and sleep-related symptoms.
- Trial name
- NCT03055156
- Testing
- Low rebound mattress toppers, High rebound mattress toppers
- Where
- United States
- Volunteers
- 558 people
- Sponsor
- Stanford University
Obstructive Sleep Apnea
Crossover Trial of AD036 in Obstructive Sleep Apnea
This is a randomized, 3-Period, Placebo-Controlled, Crossover, phase 2 clinical study to examine the efficacy and safety of AD036 versus placebo or atomoxetine in patients with obstructive sleep apnea.
- Trial name
- NCT04445688
- Testing
- AD036, Atomoxetine
- Where
- 5 sites in United States
- Volunteers
- 62 people
- Sponsor
- Apnimed
Restless Legs Syndrome
Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients
To test the effectiveness and tolerability of Lyrica at various dose levels in RLS patients
- Trial name
- NCT00676403
- Testing
- Pregabalin
- Where
- 25 sites in United States, Austria and 2 more
- Volunteers
- 137 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Insomnia, Blindness
Melatonin for Circadian Sleep Disorders in the Blind
This research project consists of a three part study with five embedded sub studies. The first study phase identifies "body rhythms" of sleepiness/wakefulness and of melatonin levels for each subject (including sub-study 1).
- Conditions
- Insomnia, Blindness, Daytime Sleepiness
- Trial name
- NCT00911053
- Testing
- Melatonin, Regular Sleep Schedule, Light
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Oregon Health and Science University
Non-24-Hour Sleep-Wake Disorder
Withdrawal Study to Demonstrate the Maintenance Effect in the Treatment of Non-24-Hour Sleep-Wake Disorder
The purpose of this study is to evaluate the maintenance effect and safety of 20 mg tasimelteon versus placebo in subjects suffering from Non-24-Hour Sleep-Wake Disorder.
- Trial name
- NCT01430754
- Testing
- tasimelteon
- Where
- 22 sites in United States
- Volunteers
- 20 people
- Sponsor
- Vanda Pharmaceuticals
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea
This trial is conducted in North America. The aim of the trial is to investigate the effect of liraglutide in obese subjects with sleep apnoea.
- Conditions
- Metabolism and Nutrition Disorder, Obesity, Obstructive Sleep Apnoea
- Trial name
- NCT01557166
- Testing
- liraglutide
- Where
- 42 sites in United States, Canada
- Volunteers
- 359 people
- Sponsor
- Novo Nordisk A/S
Sleep Disturbance
Feasibility Study of Personalized Trials to Improve Sleep Quality
The purpose of this pilot study is to assess the feasibility of using N-of-1 methods in a virtual research study of melatonin intervention for poor sleep quality.
- Trial name
- NCT05349188
- Testing
- Melatonin 3 mg, Melatonin 0.5 mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Concussion, Mild, Post-Concussion Symptoms
Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury
The purpose of the research study is to understand the effectiveness of a six-week course of light exposure on cognitive functioning, mood, activity, and sleep in people that have suffered a head injury leading to a concussion.
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT02374918
- Testing
- mTBI wavelength-1 bright light, mTBI wavelength-2 bright light, HC wavelength-1 bright light
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Severe Obstructive Sleep Apnea (Apnea Hypopnea Index > 30 Events/Hour), Hypertension
Study of Cardiovascular Disease and Obstructive Sleep Apnea
The purpose of this study is to determine if two medicines (allopurinol and losartan) can influence heart and blood vessel health compared to placebo in patients with sleep apnea who are using continuous positive airway pressure…
- Trial name
- CVD/OSA (NCT01637623)
- Testing
- Losartan, Allopurinol
- Where
- 4 sites in United States
- Volunteers
- 87 people
- Sponsor
- University of Wisconsin, Madison
Chronic Insomnia
Piloting an Internet-based Therapy for Insomnia in a Population of Veterans With Substance Use Disorders
The purposes of this study is to examine the feasibility of implementing an internet-based treatment for insomnia among veterans with substance use disorders, some with co-morbid serious mental illness, and to develop potential…
- Trial name
- NCT01949389
- Testing
- Internet-based Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Connecticut Healthcare System
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Restless Legs Syndrome, Moderate to Severe Idiopathic Restless Legs Syndrome (RLS)
The Effects Of Ropinirole On Mood Or Mild Depression In Patients With Moderate To Severe Restless Legs Syndrome
Ropinirole has shown to improve mood in depressed patients as well as to improve the symptoms of Restless Legs Syndrome. Up to 40% of RLS patients suffer from mild depression, therefore it would be important for decisions no…
- Trial name
- NCT00357097
- Testing
- Ropinirole
- Where
- 50 sites in Germany
- Volunteers
- 240 people
- Sponsor
- GlaxoSmithKline
Back Pain, Insomnia
Trial on the Effect of Optically Modified Fiber Mattress Covers on Sleep Disturbances in Patients With Chronic Back Pain
Sleep quantity and quality can be influenced by the type of mattress used. This study is being done to see if a mattress cover with optically active particles can help back pain and improve sleep quality.
- Trial name
- NCT00969540
- Testing
- Active Mattress Cover
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Irvine
Parkinson's Disease
A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease
The major purpose of the Stage 1 is to study the safety and tolerability of the proposed dosage regimen of the study drug. The form of cannabidiol (CBD) used in this study is GWP42003, supplied by GW Pharmaceuticals.
- Trial name
- NCT02818777
- Testing
- cannabidiol
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
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