Clinical trials: Sleep Disorders, Intrinsic
Obstructive Sleep Apnea
keePAP Device for Treatment of Obstructive Sleep Apnea
The aim of the study is to test the hypothesis that a new device would produce a significant decrease in obstructive breathing events during sleep as indexed by the Apnea Hyperpnoea Index (AHI) or Respiratory Disturbance Index…
- Trial name
- NCT01809418
- Testing
- keePAP
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- keepMED Ltd.
Insomnia, Sleep Disorder
SleepUp Digital CBTi-based Platform for Insomnia
Cognitive-Behavioral Therapy for insomnia (CBTi) is a well-established therapeutic intervention for insomnia. SleepUp provides a digital therapeutics platform based on CBTi and additional features.
- Conditions
- Insomnia, Sleep Disorder, Sleep Hygiene
- Trial name
- NCT04949360
- Testing
- Online Cognitive-Behavioral Therapy for Insomnia and complementary therapies, Regular Cognitive Behavioural Therapy for Insomnia, Sleep hygiene - minimal intervention
- Where
- Brazil
- Volunteers
- 280 people
- Sponsor
- SleepUp Tecnologia em Saúde Ltda
Sleep Apnea, Obstructive
cNEP for the Treatment of Obstructive Sleep Apnea
The purpose of this study is to determine whether cNEP (continuous positive external pressure) is effective in treating obstructive sleep apnea
- Trial name
- cNEP (NCT02677168)
- Testing
- cNEP
- Where
- Canada
- Volunteers
- 71 people
- Sponsor
- Sommetrics, Inc.
Obstructive Sleep Apnea
Pilot Study of Negative Pressure Sleep Therapy System to Treat Obstructive Sleep Apnea
This is a pilot study to investigate the efficacy and safety of the Negative Pressure Sleep Therapy System for the treatment of obstructive sleep apnea.
- Trial name
- NCT02324790
- Testing
- iNAP® Sleep Therapy System
- Where
- 4 sites in Taiwan
- Volunteers
- 34 people
- Sponsor
- Somnics, Inc.
Obstructive Sleep Apnea
An Exploratory Investigation of the Use of Drive App to Measure Sleep Parameters in Users of CPAP Therapy
The purpose of this study is to evaluate the usability and suitability of the Drive app (app under test) to measure sleep parameters during CPAP use.
- Trial name
- NCT04500327
- Testing
- Drive app, Non contact motion sensor
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- ResMed
Apnea, Sleep
Pharmacodynamics and Efficacy of MK-7288 in Adults With Sleep Apnea (MK-7288-010)
This is a study of the safety and efficacy of MK-7288 for the treatment of excessive daytime sleepiness (EDS) in participants with obstructive sleep apnea (OSA)/hypopnea syndrome (HS) who are compliant with effective nasal…
- Trial name
- NCT01092780
- Testing
- MK-7288, Modafinil
- Volunteers
- 56 people
- Sponsor
- Merck Sharp & Dohme LLC
Sleep Apnea, Obstructive
Feasibility and Predictive Accuracy of an In-Home Computer Controlled Mandibular Positioner in Identifying Favorable Candidates for Oral Appliance Therapy
Sleep apnea is a condition in which the throat air passage closes during sleep and repeatedly interrupts breathing. The standard treatment of sleep apnea is air pressure applied to the nose, so-called nasal CPAP, but it is not…
- Trial name
- NCT03011762
- Testing
- Computer controlled mandibular positioner
- Volunteers
- 202 people
- Sponsor
- Zephyr Sleep Technologies
Insomnia
Evaluation of an Oral Cannabidiol (CBD)-Terpene Formulation on Sleep Physiology in Participants With Insomnia
Insomnia is a disorder in which people have inadequate or poor-quality sleep due to a number of factors, such as difficulty falling asleep, waking up frequently during the night with difficulty returning to sleep, waking up too…
- Trial name
- NCT05233761
- Testing
- Defined CBD
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Defined Research
Sleep-Disordered Breathing
Comparative Assessment of Compumedics Somfit Sleep Monitoring Device
To study whether Somfit is substantially equivalent to the existing approved devices for full polysomnography and home sleep apnea testing
- Trial name
- NCT05647746
- Testing
- Compumedics Somfit HSAT device, WatchPAT HSAT device, Compumedics Grael /E-series PSG system
- Where
- Australia
- Volunteers
- 108 people
- Sponsor
- Compumedics Limited
Narcolepsy
Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Armodafinil in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy
This study is to evaluate the pharmacokinetics, pharmacodynamics, and safety of single and multiple doses of armodafinil (50, 100, and 150 mg/day) in children and adolescents with excessive sleepiness associated with narcolepsy.
- Trial name
- NCT01624480
- Testing
- Armodafinil
- Where
- 24 sites in United States, Finland
- Volunteers
- 40 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Obstructive Sleep Apnea Syndrome
Respiratory Muscle Training in Obstructive Sleep Apnea Syndrome (OSAS) Patients
The purpose of this study is to determine whether respiratory muscle training by means of normocapnic hyperpnea leads to clinical and polysomnographical improvements in patients with mild to intermediate sleep apnea syndrome.
- Trial name
- NCT00936286
- Testing
- SpiroTiger
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Idiag AG
Balance
Safety and Efficacy of Ramelteon in Adults With Chronic Insomnia
The purpose of the study is to evaluate the safety and efficacy of Ramelteon, once daily (QD), compared to placebo with Zopiclone in adults with chronic insomnia
- Trial name
- NCT00237497
- Testing
- Ramelteon, Zopiclone
- Where
- United Kingdom
- Volunteers
- 275 people
- Sponsor
- Takeda
Sleep Apnea, Obstructive
SensAwake™ Sleep Quality Trial
The SensAwake™ modification to the Fisher and Paykel automatically titrating positive airway pressure (APAP) device aims to sense whether the patient is awake via respiratory patterns that differentiate between sleep and wake.
- Trial name
- SASQT (NCT00811213)
- Testing
- SleepStyle 200 Auto Series with SensAwake, SleepStyle 200 Auto Series with out SensAwake
- Where
- Australia
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Study of TAK-925 in Participants With Obstructive Sleep Apnea (OSA) Who Are Experiencing Excessive Daytime Sleepiness (EDS) Despite Adequate Use of Continuous Positive Airway Pressure (CPAP)
The purpose of this study is to evaluate the safety and tolerability of administering a single intravenous (IV) infusion dose of TAK-925 to adults with obstructive sleep apnea (OSA) who are experiencing excessive daytime…
- Trial name
- NCT04091425
- Testing
- TAK-925
- Where
- 18 sites in United States
- Volunteers
- 25 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Primary Insomnia
Efficacy and Safety of Circadin® 2 mg in the Treatment of Primary Insomnia Patients
This is a randomised, placebo controlled study to evaluate the efficacy of a 3 week treatment period with Circadin® 2 mg in shortening sleep latency in patients with primary insomnia aged 18-80 with melatonin deficiency.
- Trial name
- NCT00397189
- Testing
- Circadin
- Where
- United Kingdom
- Volunteers
- 930 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Mild-Moderate Obstructive Sleep Disordered Breathing
Non-Inferiority Trial of Acute HFT Versus nCPAP
Order randomized crossover non-inferiority study evaluating the acute efficacy of High Flow Therapy (HFT) as compared to nasal Continuous Positive Airway Pressure therapy (CPAP) in the management of apnea / hypopnea index (AHI).
- Trial name
- NCT01860560
- Testing
- High-Flow Therapy, Continuous Positive Airway Pressure
- Where
- United States
- Sponsor
- Vapotherm, Inc.
Obstructive Sleep Apnea
An Investigation to Test the Efficacy of the High Flow (HF) Continuous Positive Airway Pressure (CPAP) in Patients With Obstructive Sleep Apnea (OSA)
Phase One: High Flow (HF) CPAP (HF-CPAP) Titration: Participants will attend the sleep lab to undergo a comprehensive split-night respiratory PSG.
- Trial name
- NCT01025440
- Testing
- Continuous Positive Airway Pressure
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Home Study of Subjects Who Have Completed a Previous Continuous Negative External Pressure (cNEP) Clinical Trial
This study is designed to determine whether subjects who were responders to cNEP during an overnight sleep lab titration in a previous clinical trial, Study SOM-012, will maintain a response throughout the night for up to two…
- Trial name
- NCT03108417
- Testing
- continuous negative external pressure
- Where
- United States
- Sponsor
- Sommetrics, Inc.
COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS)
The Effect of Mask Design on Ventilation Parameters in COPD and OHS Patients on Long-term Home Non-invasive Ventilation. An Experimental Study.
Chronic obstructive pulmonary disease (COPD) and obesity hypoventilation syndrome (OHS) are respiratory conditions that disrupt normal breathing.
- Trial name
- NCT06972589
- Testing
- Investigational Mask, Conventional mask
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare
Restless Legs Syndrome
An Extension Trial to Investigate Long-Term Treatment With Transdermal Rotigotine in Idiopathic Restless Legs Syndrome
This is a multicenter, open-label trial to assess safety and tolerability of rotigotine (SPM 936) in subjects with idiopathic Restless Legs Syndrome (RLS), administered at an optimal dose for up to 1 year.
- Trial name
- NCT00263068
- Testing
- Rotigotine
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- UCB Pharma
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