Clinical trials: Sleep Disorders, Intrinsic
Obstructive Sleep Apnea, Snoring
A Trial to Evaluate a Device for the Treatment of OSA and Snoring
To evaluate the safety and efficacy of the Tongue Advancement Retainer Device in treating subjects with Obstructive Sleep Apnea (OSA) and snoring.
- Trial name
- OPEN (NCT01772017)
- Testing
- Tongue Advancement Retainer Device
- Where
- 3 sites in United States, Australia
- Volunteers
- 15 people
- Sponsor
- Sleepy, Inc
Sleep, Sleep Duration
Non-Invasive At-Home Sleep Therapy System
The goal of this clinical trial is to learn about the ability of non-invasive brain stimulation during sleep to enhance people's deep sleep and its potential benefit on memory in healthy adults via home use sleep therapy device…
- Conditions
- Sleep, Sleep Duration, Sleep Quality
- Trial name
- NCT05970276
- Testing
- Deep Sleep (N3) Enhancement with TES
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brain Electrophysiology Laboratory Company
PostTraumatic Stress Disorder, Sleep Disorder
NightWare Open Enrollment Study
This study will provide measures of safety and efficacy of the NightWare digital therapeutic system (iPhone + Apple watch + proprietary application) for the treatment of nightmare disorder associated with post-traumatic stress…
- Conditions
- PostTraumatic Stress Disorder, Sleep Disorder, Stress Disorder, Sleep Initiation and Maintenance Disorders
- Trial name
- NWOES (NCT03828656)
- Testing
- NightWare Therapeutic System
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- NightWare
Idiopathic Hypersomnia
A Study of Oral BTD-001 in Adults With Idiopathic Hypersomnia
This is a randomized, placebo-controlled, double-blind, crossover study of oral BTD-001 in adults with Idiopathic Hypersomnia.
- Trial name
- ARISE2 (NCT03542851)
- Testing
- Pentetrazol (PTZ)
- Where
- 32 sites in United States
- Volunteers
- 80 people
- Sponsor
- Balance Therapeutics
Sleep Disturbance
A Study of a Sleep Supplement to Improve Sleep in Women Going Through Menopause
This study evaluated whether a daily dietary sleep supplement could improve sleep in women aged 40 to 65 who experience moderate sleep disturbances during menopause.
- Trial name
- NCT07375095
- Testing
- Sleep Supplement
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Bonafide Health
Obstructive Sleep Apnea (OSA)
Improved Automatic CPAP Algorithm to Treat Obstructive Sleep Apnea (OSA)
The purpose of this study is to compare a modified AutoSet algorithm running on research hardware versus the traditional AutoSet algorithm running on an S7 AutoSet Spirit.
- Trial name
- NCT00850434
- Testing
- Modified AutoSet Algorithm, Standard AutoSet Algorithm
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- ResMed
Sleep Apnea
A Study of Danavorexton in People With Obstructive Sleep Apnea After General Anesthesia for Abdominal Surgery
The main aim is to see if danavorexton can help improve people's breathing in the recovery room after abdominal surgery.
- Trial name
- NCT05814016
- Testing
- Danavorexton
- Where
- 19 sites in United States
- Volunteers
- 41 people
- Sponsor
- Takeda
PTSD, Sleep Disturbance
Electrical Vestibular Nerve Stimulation (VeNS) as a Method of Sleep Management in People With PTSD
This double blind randomized controlled study will enroll 20 subjects and will be conducted remotely. The study will be randomized for an 8-week period with a 1:1 active to sham device allocation.
- Conditions
- PTSD, Sleep Disturbance, Insomnia
- Trial name
- NCT04780893
- Testing
- Modius Sleep
- Volunteers
- healthy volunteers welcome
- Sponsor
- Neurovalens Ltd.
Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Evaluation of the F&P Mask, US, 2026
This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P PAP mask in a home environment.
- Trial name
- NCT07826429
- Testing
- F&P Licorice Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Study for Efficacy and Dose Escalation of AD313 + Atomoxetine (SEED)
The SEED study is designed to assess the safety and efficacy for Obstructive Sleep Apnea (OSA) of 3 escalating dose combinations of atomoxetine with AD313 compared to baseline and to atomoxetine alone.
- Trial name
- SEED (NCT05101122)
- Testing
- Dosing 1: Atomoxetine, AD313
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Apnimed
Obstructive Sleep Apnea
Australian Clinical Study of the Apnex Medical HGNS System to Treat Obstructive Sleep Apnea
The overall goal of the study is to evaluate the safety, efficacy and therapy settings of the HGNS System for stimulating the hypoglossal nerve to help maintain an open airway in subjects with obstructive sleep apnea (OSA).
- Trial name
- NCT01186926
- Testing
- HGNS Treatment
- Volunteers
- 40 people
- Sponsor
- Apnex Medical, Inc.
Sleep Apnea, Obstructive
Efficacy of Aerosal® in the Treatment of Sub-Obstructive Adenotonsillar Hypertrophy and Related Diseases
The purpose of this study is to evaluate the efficacy of Aerosal® compared to a placebo treatment in the prognosis of sub-obstructive adenotonsillar hypertrophy present for at least six months.
- Trial name
- NCT01574885
- Testing
- Halotherapy
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Tecno Sun SRL
Sleep Initiation and Maintenance Disorders, Alzheimer Disease
Safety and Efficacy of Suvorexant (MK-4305) for the Treatment of Insomnia in Participants With Alzheimer's Disease (MK-4305-061)
This study aims to examine the safety and efficacy of suvorexant (MK-4305) to improve sleep in individuals with Alzheimer's disease (AD).
- Trial name
- NCT02750306
- Testing
- Suvorexant
- Volunteers
- 285 people
- Sponsor
- Merck Sharp & Dohme LLC
Sleep Disordered Breathing, Obstructive Sleep Apnea
An Investigation to Test a Prototype Full-face Mask in the Home Setting
This investigation is a prospective non-blinded and non-randomized clinical investigation. This investigation is designed to evaluate the performance (leak and comfort) as well as participant's overall acceptance of the Jupiter…
- Trial name
- NCT02938208
- Testing
- Jupiter Full Face Mask
- Where
- 2 sites in New Zealand
- Volunteers
- 14 people
- Sponsor
- Fisher and Paykel Healthcare
Insomnia
Performance Evaluation of the Dreem 3 System for Sleep Assessment in Patients With Insomnia
The objective of the clinical investigation is to assess the performance of the Dreem 3 System for sleep assessment compared to a FDA-cleared PSG assessment and human sleep expert scoring in a population experiencing insomnia…
- Trial name
- NCT05438017
- Testing
- Dreem 3 System vs PSG
- Where
- 2 sites in United States, France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Dreem
Sleep Disorder; Breathing-Related
A Study to Determine Preferences Towards Interface Products
Enrolled Naïve participants will be randomized to one of two arms, the investigational or control arm. Once randomized the institutions will fit the participant with the procedures outlined in the protocol.
- Trial name
- NCT03948152
- Testing
- Standard of Care, Mask Advice Tool
- Where
- 5 sites in United States
- Volunteers
- 310 people
- Sponsor
- Philips Respironics
Sleep Disturbance
A Study to Evaluate the Effects of the Speed Sleep Supplement on Sleep Quality and Quantity
This study evaluates the effects of the Speed Sleep supplement on sleep quality and quantity in adults aged 18-65 years. Participants will be randomized to receive either the supplement or placebo for 4 weeks, with outcomes…
- Trial name
- NCT07564817
- Testing
- Dietary Supplement: Speed Sleep
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bio Nature Health
Obstructive Sleep Apnea
Improving the Efficiency of the Digital Sleep Workflow Using MATRx Plus
Sleep apnea (OSA) is a condition in which the air passage in the throat closes or partly closes during sleep and repeatedly interrupts breathing.
- Trial name
- NCT03579225
- Testing
- MATRx plus test
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Zephyr Sleep Technologies
Insomnia
STATE Trial: SusTained Attention Training to Enhance Sleep
This study is a validation study to document the acceptability of the Tonic and Phasic Alertness Training (TAPAT) training program in older adults with chronic late-life insomnia.
- Trial name
- STATE (NCT02921074)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Posit Science Corporation
Narcolepsy
Observational Study of LUMRYZ in Narcolepsy
This is an observational study of LUMRYZ prescribed in clinical practice. Patients are asked if they would be willing to complete questionnaires over a 4-month period after starting LUMRYZ.
- Trial name
- REFRESH (NCT06792708)
- Testing
- LUMRYZ
- Where
- 12 sites in United States
- Volunteers
- 71 people
- Sponsor
- Avadel
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