Clinical trials: Sleep Disorders, Intrinsic
Sleep Apnea
Clinical Validation of New Commercial Sleep Monitoring Devices
This study seeks to validate three new commercial sleep monitoring devices: Fitbit, Jawbone UP, and Microsoft Band by comparison against concurrent polysomnography (PSG), which is considered the gold standard for sleep…
- Trial name
- NCT02779543
- Testing
- Fitbit, Jawbone UP, Microsoft Band
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Sleep Apnea, Obstructive
Positive Airway Pressure Program
Obstructive Sleep Apnea (OSA) is a common sleep disordered breathing condition effecting around 2-4% of the middle aged population and is characterized by periodic collapse of the upper airway during sleep.
- Trial name
- NCT02331992
- Testing
- Adherence program
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep Apnea, Obstructive, Sleep Apnea, Central
DreamKit Diagnostic Validation
This study has been developed in order to demonstrate diagnostic efficacy of the DreamKit device against polysomnography.
- Trial name
- NCT04671342
- Testing
- DreamKit
- Where
- 7 sites in United States
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Sleep, Insomnia
Treatment of Insomnia and Glucose Metabolism
Available data suggest that obtaining adequate sleep is associated with a better ability of the body to use carbohydrates as a source of energy and a lower risk of developing diabetes.
- Conditions
- Sleep, Insomnia, Insulin Resistance
- Trial name
- NCT00724282
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Severe Obstructive Sleep Apnea (Apnea Hypopnea Index > 30 Events/Hour), Hypertension
Study of Cardiovascular Disease and Obstructive Sleep Apnea
The purpose of this study is to determine if two medicines (allopurinol and losartan) can influence heart and blood vessel health compared to placebo in patients with sleep apnea who are using continuous positive airway pressure…
- Trial name
- CVD/OSA (NCT01637623)
- Testing
- Losartan, Allopurinol
- Where
- 4 sites in United States
- Volunteers
- 87 people
- Sponsor
- University of Wisconsin, Madison
Respiratory Depression, Obstructive Sleep Apnea
Effect of Opioids on Ventilation in Children With Obstructive Sleep Apnea
The sole objective in this study is to evaluate if routine amounts of opioids given for tonsillectomy in children have greater amounts of respiratory depression in children with documented obstructive sleep apnea when compared…
- Trial name
- NCT03938259
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Sleep Apnea, Obstructive
Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea
We would like to test the effect of opioid medication on pain sensitivity in subjects who have been diagnosed with a sleep disorder called Obstructive Sleep Apnea (OSA) compared to other subjects without OSA.
- Trial name
- NCT00672737
- Testing
- Remifentanil, Cold pain threshold and tolerance, Heat pain threshold and tolerance
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Stanford University
Non Alcoholic Fatty Liver Disease
The Role of Obstructive Sleep Apnea in Children With Fatty Liver Disease
The purpose of this study is to examine whether CPAP therapy can reduce or eliminate hepatic fat accumulation in obese children and adolescents.
- Trial name
- NCT02134522
- Testing
- Continuous positive airway pressure (CPAP).
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University
Cheyne-Stokes Respiration, Sleep Apnea, Central
Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients
Pilot study testing the Bipap autoSV Advanced Algorithm during full night, in-lab polysomnography (PSG) and 3 months at home on patients with Central Sleep Apnea, Hunter Cheyne Stokes Respiration, or Complex Sleep Apnea.
- Trial name
- NCT01199042
- Testing
- BiPAP autoSV Advanced
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Philips Respironics
Insomnia, Sleep Disorders
Treating Sleep Problems in VA Adult Day Health Care
The Veterans Millennium Health Care and Benefits Act (Millennium Act) of 1999 mandated the Department of Veterans Affairs (VA) to provide non-institutional long-term care to veterans.
- Trial name
- HERO-ADHC (NCT01259401)
- Testing
- Sleep Intervention Program, Sleep Education control
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea (OSA), Post-Traumatic Stress Disorder (PTSD)
Comparison Study Using APAP With and Without SensAwake in Patients With OSA and PTSD
The purpose of this research is to examine the application of AutoCPAP with and without SensAwake in subjects with OSA and Post-Traumatic Stress Disorder (PTSD), and evaluate whether patients achieve better sleep quality and…
- Trial name
- NCT02549508
- Testing
- AutoCPAP with SensAwake On, AutoCPAP with SensAwake Off
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Fisher and Paykel Healthcare
Insomnia, Breast Cancer
PERSONAL - Sleep In Breast Cancer
Sleep is essential for human function, immunity, and well-being. In the general population, sleep disturbance and insomnia cause significant health problems and impact on the quality of life of many individuals.
- Trial name
- NCT05093426
- Testing
- Stage 2 Digital sleep diary app
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- Closed Loop Medicine
Obstructive Sleep Apnea
Adherence Risk Indicator Validation Study
While continuous positive airway pressure (CPAP) is the gold standard treatment of obstructive sleep apnea (OSA), this therapy is often discontinued or not used optimally.
- Trial name
- ARI (NCT02230085)
- Testing
- Administration of the questionnaire and monitoring of CPAP adherence
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Fisher and Paykel Healthcare
Primary Insomnia
Safety and Efficacy Study of Suvorexant in Participants With Primary Insomnia - Study A (MK-4305-028)
This is a multicenter study to test the hypothesis that suvorexant (MK-4305) is superior to placebo in improving insomnia as measured by change from baseline in: subjective total sleep time and time to sleep onset, wake time…
- Trial name
- NCT01097616
- Testing
- Suvorexant High Dose (HD), Suvorexant Low Dose (LD)
- Volunteers
- 1,023 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Low Back Pain, Hip Ostearthritis
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
Back pain is a huge problem for millions of Americans, including nearly 11 million Veterans. Our older Veterans suffer the most. Citizens spend billions of dollars, yet consistently get poor results.
- Conditions
- Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia
- Trial name
- NCT02697435
- Testing
- Patient-Centered Care, Imaging-Directed Care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Sleep Apnea
Comparison of Breathing Event Detection by a Continuous Positive Airway Pressure Device to Clinical Polysomnography
The study is to compare the performance of a CPAP (continuous positive airway pressure) device to a clinical polysomnography (PSG) in identifying breathing events in patients with obstructive sleep apnea.
- Trial name
- NCT00836758
- Testing
- Analysis with AED and manual PSG scoring
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Philips Respironics
Sleep Apnea, Heart Failure
Diagnosis and Treatment of Sleep Apnea in the Acute Exacerbation of Heart Failure
Congestive heart failure affects 2.3 percent of the population (approximately 4,900,000) with an incidence of 10 per 1,000 of the population after the age of 65 (1).
- Trial name
- NCT00701038
- Testing
- auto adjusting bi-level positive airway pressure device
- Volunteers
- 54 people
- Sponsor
- Rami Khayat
Insomnia, Primary, Depression
Sleep to Prevent Evolving Affecting Disorders
The primary objective of the proposed research is to determine the efficacy of Digital Cognitive Behavior Therapy (dCBTI) in reducing severity of depression and also in preventing the incidence and relapse of depression among…
- Trial name
- SPREAD (NCT02988375)
- Testing
- dCBTI, Sleep Education
- Where
- United States
- Volunteers
- 1,385 people
- Sponsor
- Henry Ford Health System
Sleep Apnea
Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036)
This study will evaluate the safety, tolerability, and effect of multiple doses of suvorexant (MK-4305) on respiratory function in participants with mild to moderate obstructive sleep apnea (OSA) compared to administration of…
- Trial name
- NCT01300455
- Testing
- Suvorexant
- Volunteers
- 26 people
- Sponsor
- Merck Sharp & Dohme LLC
Obstructive Sleep Apnea
Pilairo Lab Market Research
The purpose of the study is to observe the Pilairo mask in a lab setting.
- Trial name
- NCT01824979
- Testing
- CPAP mask ( Pilairo), Other CPAP mask
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Fisher and Paykel Healthcare