Clinical trials: Sleep Disorders, Intrinsic
Sleep Apnea
Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea
Currently, there is no pharmacological intervention for OSA that targets multiple pathophysiological deficits in combination. Here the investigators study the effect on sleep apnea severity of combinations of pharmacological…
- Trial name
- ComboPlus (NCT03892772)
- Testing
- SAS0421a, SAS0421b, SAS0421c
- Where
- 2 sites in United States, Australia
- Volunteers
- 23 people
- Sponsor
- Brigham and Women's Hospital
Insomnia
Registry to Collect Information on Pregnancy, Neonatal, and Infant Outcomes in Pregnant Women Exposed to QUVIVIQ®
This study will investigate pregnancy, neonatal, and infant outcomes in women exposed to QUVIVIQ during pregnancy compared to women unexposed to QUVIVIQ during pregnancy.
- Trial name
- NCT06498128
- Testing
- Daridorexant, Non-orexin receptor antagonist medications for insomnia, No insomnia medication
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Dementia, Mild Cognitive Impairment
A Digital Cognitive Behavioural Therapy for Insomnia Intervention in Mild Cognitive Impairment and Mild Dementia
The purpose of this study is to assess the feasibility of conducting a definitive randomised controlled trial that will determine the effectiveness of a digital cognitive behavioural therapy for insomnia intervention (Sleepio) in…
- Conditions
- Dementia, Mild Cognitive Impairment, Insomnia, Sleep
- Trial name
- REST (NCT07363928)
- Testing
- Digital cognitive behavioural therapy for insomnia
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- University College Cork
Stress, Insomnia
A Clinical Trial of De-Stress & Snooze Gummies in Reducing Stress and Insomnia Disorder
The current study focuses on clinical validation of efficacy of nutraceutical product in management of sleep disorder. Improved sleep quality contributes significantly to cognitive function.
- Conditions
- Stress, Insomnia, Quality of Life
- Trial name
- NCT06571331
- Testing
- De-Stress & Snooze Gummies-U001, De-Stress & Snooze Gummies-I001
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Herbolab India Pvt. Ltd.
Post Traumatic Stress Disorder, Obstructive Sleep Apnea
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Conditions
- Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
- Trial name
- NCT05156112
- Testing
- Positive Airway Pressure Device
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea
The Effect of Melatonin on Sleep and Ventilatory Control in Obstructive Sleep Apnea
Our hypothesis is that oxidative stress induced during repeated apneas in obstructive sleep apnea (OSA) patients alters the neural control of breathing which destabilizes ventilatory control and exacerbates OSA.
- Trial name
- NCT02484300
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Insomnia
An Exploratory Study of NBI-34060 Capsules and Next Day Functioning
NBI-34060 is an investigational (research) medication being studied in people with insomnia. The current study is designed to evaluate how people, who experience a nighttime awakening with difficulty returning to sleep, feel…
- Trial name
- NCT00525941
- Testing
- NBI-34060
- Where
- 4 sites in United States
- Sponsor
- Neurocrine Biosciences
Insomnia
Improving Negative Stressful Perseverations in Insomnia to Revitalize Expectant Moms
The purpose of this research is to evaluate telemedicine treatments for sleep in pregnant women. As pregnant women are vulnerable to sleep problems, the investigators aim to explore whether these types of treatment will improve…
- Trial name
- INSPIRE (NCT04445805)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBTI), Perinatal-enhanced Behavioral Therapy for Insomnia, Attention Control
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Henry Ford Health System
Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Domiciliary Nasal High Flow and Patient Outcomes in Chronic Hypercapnic Respiratory Failure in the United Kingdom
Chronic hypercapnic respiratory failure (CHRF) in the context of Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS) is associated with increased mortality.
- Conditions
- Chronic Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome (OHS), Nasal High Flow
- Trial name
- NCT05167201
- Testing
- Nasal High Flow
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Polypharmacy, Insomnia
MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings
Scientific advances are constantly leading to better treatments. However, it is quite challenging for healthcare systems, including VA, to ask very busy providers to change the way they practice.
- Conditions
- Polypharmacy, Insomnia, Anticoagulants
- Trial name
- MIDAS cRCT (NCT05065502)
- Testing
- Academic Detailing (AD), LEAP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Asthma, Insomnia
Solving Insomnia Electronically: Sleep Treatment for Asthma
Insomnia is commonly reported by adults with asthma. Insomnia can worsen asthma patients' quality of life and increase the risk for asthma attacks.This clinical trial will compare sleep and asthma control in adults with asthma…
- Trial name
- SIESTA (NCT03327519)
- Testing
- SHUTi, Emmi
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Pittsburgh
Opioids, Obstructive Sleep Apnea (OSA)
Impacts of Opioids on Respiratory Drive During Sleep
The investigators are studying the impact that opioids have on breathing during sleep in healthy participants and those diagnosed with obstructive sleep apnea.
- Trial name
- OIRD (NCT06854211)
- Testing
- Morphine p.o.
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Apnea Syndrome
Validation of Apnea LinkTM for Sleep Apnea Syndrome Screening in a Bariatric Population
Sleep apnea syndrome (OSA) frequently occurs in obese population undergoing bariatric surgery. There is a need for alternative screening tools for sleep apnea detection in the pre-operative period.
- Trial name
- NCT01354756
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Postmenopausal Flushing, Cardiovascular Risk Factor
Hot Flash as a Marker of Cardiovascular Risk in Recent Postmenopause: Effects of Non-hormonal Treatments
Hot flashes, vasomotor symptoms that affect many postmenopausal women, are associated with cardiovascular disease and endothelial dysfunction.
- Conditions
- Postmenopausal Flushing, Cardiovascular Risk Factor, Endothelial Dysfunction
- Trial name
- NCT03149419
- Testing
- Paroxetine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Obstructive Sleep Apnea
Obstructive Sleep Apnea and Comprehensive Remotely-supervised Rehabilitation Program
The purpose of this study is to investigate the feasibility and effect of a 12-week remotely-supervised rehabilitation program in male patients between 25-65 years old with newly diagnosed obstructive sleep apnea with…
- Trial name
- NCT04759456
- Testing
- Remotely-supervised rehabilitation program
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Brno University Hospital
Sleep Initiation and Maintenance Disorders
Randomised, Double-blind Study to Investigate the Safety and Efficacy of Brotizolam in Insomnia Outpatients.
To investigate the efficacy and safety of Brotizolam in the treatment of patients with insomnia in comparison with that of Estazolam
- Trial name
- NCT00347295
- Testing
- Brotizolam, Estazolam
- Where
- 8 sites in China
- Volunteers
- 253 people
- Sponsor
- Boehringer Ingelheim
Obstructive Sleep Apnea, Pulmonary Edema Cardiac Cause
Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: CPAP-CARE STUDY.
Despite the advances in the treatment of acute cardiogenic pulmonary edema (ACPE), the readmissions rates and cardiovascular events remain very high.
- Trial name
- CPAP-CARE (NCT03936751)
- Testing
- CPAP, Nasal Strips
- Where
- 4 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo
Multiple Sclerosis, Restless Legs Syndrome
Efficacy of BIPAMS for Restless Legs Syndrome in Adults With Multiple Sclerosis: A Pilot Study
The purpose of this study is to evaluate the efficacy of a 16-week behavioral intervention for increasing physical activity and reducing restless legs syndrome (RLS) severity in persons with multiple sclerosis (MS) and RLS.
- Trial name
- NCT04061681
- Testing
- Behavioral Intervention (BIPAMS)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Alabama at Birmingham
Sleep Quality, Mental Health
Effect of a Sleep Hygiene-based Intervention on Sleep Quality and Mental Health in Medical Students
The aim of the study is to investigate whether an online sleep hygiene programm is as effective as a face-to-face programm in improving sleep quality and mental health in medical students.
- Conditions
- Sleep Quality, Mental Health, Students, Medical
- Trial name
- NCT07043530
- Testing
- In-person sleep hygiene-based intervention, Online sleep hygiene-based intervention
- Where
- Mexico
- Volunteers
- 78 people
- Sponsor
- Universidad Autónoma de Yucatán
Insomnia
A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)
People with opioid use disorder (OUD) can have trouble falling or staying asleep. Researchers want to know if suvorexant will help people with OUD fall asleep and stay asleep.
- Trial name
- NCT06655883
- Testing
- Suvorexant
- Where
- 13 sites in United States
- Volunteers
- 300 people
- Sponsor
- Merck Sharp & Dohme LLC
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