Clinical trials: Sleep Disorders, Intrinsic
Obesity Hypoventilation Syndrome
A Trial of Rehabilitation in Obesity Hypoventilation Syndrome (OHS)
Obesity is an escalating problem in the UK and a proportion of these patients have a condition known as Obesity Hypoventilation Syndrome (OHS).
- Trial name
- NCT01483716
- Testing
- Rehabilitation
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Primary Insomnia
A Dose-ranging, Multicenter Polysomnography Trial of PD 0200390 in Adults With Primary Insomnia
The purpose of this study is to further explore an effective dose range of PD0200390 for the treatment of patients with insomnia.
- Trial name
- NCT00551148
- Testing
- PD 0200390
- Where
- 16 sites in United States
- Volunteers
- 92 people
- Sponsor
- Pfizer
Obstructive Sleep Apnea
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with obstructive sleep apnea (OSA) who are not on PAP therapy and are…
- Trial name
- MARITIME-OSA-2 (NCT07226765)
- Testing
- Maridebart cafraglutide
- Where
- 57 sites in United States, Australia and 9 more
- Volunteers
- 250 people
- Sponsor
- Amgen
Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases
Randomized Control Trials of Surgery for Pediatric OSA
Randomized study on pediatric OSA with 2 groups: mild-moderate OSA and severe OSA. Mild-moderate are randomized to either expectancy or ATE. Severe are randomized to either ATE or APP. Pediatric age span of 2 until 4,9 years.
- Conditions
- Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases, Pediatric Disorder
- Trial name
- NCT02315911
- Testing
- ATE, APP
- Where
- Sweden
- Volunteers
- 143 people
- Sponsor
- Karolinska University Hospital
Obstructive Sleep Apnea
Correlation Between CPAP Compliance and Food Intake Timing
Despite widespread agreement that continuous positive airway pressure is effective therapy for obstructive sleep apnea, it is estimated that 50% of patients recommended for therapy are noncompliant 1 year later.
- Trial name
- TLMECC (NCT01851811)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hackensack Meridian Health
Obesity, Obstructive Sleep Apnea Syndrome
Pilot Study to Assess the Effectiveness of Tonsil and Adenoidectomy (T+A) in Overweight Children and Adolescents
Obesity has reached epidemic proportions in the United States with roughly 20% of American children being overweight and has serious consequences such as sleep apnea.Additionally, obesity is known to result in the earlier onset…
- Trial name
- NCT00222963
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Rochester
Obstructive Sleep Apnea
Assessment of the Effect of PAP on Energy and Vitality in Mild OSA Patients: The Merge Study
The investigators wish to prospectively determine the response to CPAP in patients presenting with mild OSA. In many healthcare systems, patients with mild OSA (AHI 5-15) are not reimbursed for treatment.
- Trial name
- NCT02699463
- Testing
- Continous Positive Airway Pressure, Control Group
- Where
- 11 sites in United Kingdom
- Volunteers
- 301 people
- Sponsor
- ResMed
Sleep, Fatigue
Sleep, Mindfulness, and Shift-Level Safety Performance in Perianesthesia Nurses
Perianesthesia (preoperative and postanesthesia care unit, PACU) nurses work rotating, often extended shifts that can disrupt sleep and increase fatigue, both of which are recognized threats to patient safety in high-acuity…
- Conditions
- Sleep, Fatigue, Patient Safety
- Trial name
- NCT07832721
- Testing
- Sleep, Mindfulness, and Shift-Level Safety Observation Toolkit
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Volkan Gokmen
Sleep Apnea, Obstructive
Long Term Efficacy of Education Programme on Continuous Positive Airway Pressure Treatment
Obstructive sleep apnea (OSA) is a common sleep disorders associated with excessive daytime sleepiness and cardiovascular disease.
- Trial name
- NCT01428921
- Testing
- Theory based education and brief motivation interview
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Obstructive Sleep Apnea
Propranolol for Sleep Apnea Therapy
The primary objective of this study is to test whether a beta blocker, propranolol, lowers the overnight heart rate sleep in obstructive sleep apnea (OSA) during CPAP withdrawal.
- Trial name
- ProSAT (NCT03049306)
- Testing
- Propranolol Oral Tablet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Children, Postoperative Pain
Acupuncture for Tonsillectomy Pain
Pain after tonsillectomy can be severe and last ten days. Various new surgical instruments have been developed over the years in an attempt to reduce postoperative pain with mixed results and increased costs; no single…
- Conditions
- Children, Postoperative Pain, Tonsillar Hypertrophy, Obstructive Sleep Apnea
- Trial name
- NCT01389349
- Testing
- Acupuncture
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Children's ENT of San Diego, Inc.
Insomnia
A Study to Evaluate the Pharmacokinetics of LY2624803 in Subjects With Hepatic Impairment
The purpose of this study is to evaluate the impact of hepatic dysfunction on the pharmacokinetics and safety of LY2624803 and its major metabolite, LSN2797276.
- Trial name
- NCT01257178
- Testing
- LY2624803
- Where
- 4 sites in Germany, Hungary and 1 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Sleep Apnea, Obstructive
Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome
The primary objectives of the study are to determine the effectiveness of PROVIGIL treatment, compared to placebo treatment, in children and adolescents with excessive sleepiness (ES) associated with obstructive sleep…
- Trial name
- NCT00107809
- Testing
- Modafinil
- Where
- 64 sites in United States, Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cephalon
Insomnia
A Preliminary Study of Model-driven Individualized Transcranial Electrical Stimulation for Insomnia
This study is designed to evaluate the efficacy and to explore the best individualized stimulus paradigm of transcranial Electrical Stimulation for insomnia patients.
- Trial name
- NCT05445999
- Testing
- High-Definition transcranial electrical stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Mental Health Center
Mental Illness, Burnout Syndrome
Physician Mental Health Study for Medical Trainees
The purpose of this study is to determine whether use of a suite of smart phone enabled mobile health devices can reduce burnout in medical trainees.
- Trial name
- NCT02950363
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Mild Traumatic Brain Injury, Post-Concussion Syndrome
Treatment of Insomnia for Adolescents With Mild Traumatic Brain Injury
A substantial number of children and adolescents sustain a mild traumatic brain injury (mTBI) each year. Although research supports that the vast majority of youth will recover quickly and return to normal functioning, some…
- Conditions
- Mild Traumatic Brain Injury, Post-Concussion Syndrome, Insomnia
- Trial name
- NCT03688984
- Testing
- Cognitive Behavioural Therapy for Insomnia
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Restless Legs Syndrome (RLS)
Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome
Several studies report association between restless legs syndrome (RLS), HTA and cardiovascular diseases . The mechanisms involved in this relationship remained unknown, but several evidences favor the role of periodic limb…
- Trial name
- NCT01823770
- Testing
- Rotigotine
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Fibromyalgia, Chronic Fatigue Syndrome (CFS)
Effect of Physical Exercise and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia
Fibromyalgia (FMS) is a chronic, multifactorial syndrome characterized by widespread pain, fatigue, and cognitive disturbances. This interventional study evaluates the impact of structured physical training using…
- Trial name
- NCT07242573
- Testing
- Physical Training Program, NESA X-Signal, Conventional Physiotherapy
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
OSA - Obstructive Sleep Apnea
Effects of Eszopiclone and Lemborexant in People With OSA With a Low Arousal Threshold Who Have Difficulty Sleeping
Insomnia and obstructive sleep apnoea (OSA) are very common conditions, collectively estimated to affect 2 billion people globally, and share many of the same symptoms.
- Trial name
- ELOSA (NCT06928766)
- Testing
- Eszopiclone 3 mg, Lemborexant 10mg
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Flinders University
Obstructive Sleep Apnea
Clinical Efficacy of High-flow Nasal Cannula Oxygen Therapy in Patients With Obstructive Sleep Apnea
Patients meeting the criteria of obstructive sleep apnea were included, and all patients signed informed consent, which met the requirements of the ethics Committee of our unit. All subjects were hospitalized patients.
- Trial name
- NCT05549245
- Testing
- high-flow nasal cannula oxygen therapy,, CPAP
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Qilu Hospital of Shandong University
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