Clinical trials: Sleep Disorders, Intrinsic
Chronic Insomnia
Efficacy and Safety of Ramelteon in Subjects With Mild to Moderate Alzheimer's Disease
The purpose of this study is to determine the efficacy of ramelteon, once daily (QD), in subjects with mild to moderate Alzheimer's Disease and sleep disturbance
- Trial name
- NCT00325728
- Testing
- Ramelteon
- Where
- 72 sites in United States
- Volunteers
- 74 people
- Sponsor
- Takeda
Sleep Apnea, Obstructive
Effects of Quetiapine on Sleep and Next Day Alertness in People With Obstructive Sleep Apnea
Quetiapine is medication used to treat schizophrenia and bipolar disorder. Increasingly, low doses of quetiapine are prescribed "off-label" for insomnia.
- Trial name
- QOSA (NCT05303935)
- Testing
- Quetiapine 50 MG
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Flinders University
Obstructive Sleep Apnea
Impact of Myofuntional Therapy Program on Increasing Tongue Strength and Improving Sleep Apnea
This Research studies for compare muscle strength among OSA patients who treat with myofunctional therapy program in Rajavithi hospital
- Trial name
- NCT05043389
- Testing
- myofunctional therapy program
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Insomnia, Brain Injury
Effect of Rozerem on Sleep Among People With Traumatic Brain Injury
This pilot study proposes to examine the effect of Rozerem on sleep/wake patterns among individuals with Traumatic Brain Injury (TBI) experiencing sleep disturbance, using both objective and subjective measures.
- Trial name
- NCT01207050
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Schizophrenia, Psychotic Disorders
Efficacy and Mechanisms of Change of an Emotion-oriented Version of Cognitive-behavioral Therapy for Psychosis
The aim of the present single-blind randomized-controlled therapy study is to assess the efficacy of a new form of Cognitive Behavioral Therapy for delusions with a focus on emotion regulation, improvement of self-esteem and…
- Conditions
- Schizophrenia, Psychotic Disorders, Delusions, Emotions
- Trial name
- CBTd-E (NCT02787135)
- Testing
- emotion-oriented Cognitive Behavior Therapy
- Where
- 2 sites in Germany
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Obstructive Sleep Apnea
Evaluation of Sleep Apnea Related Inflammation With CRP, ESR and Neutrophil toLymphocyte Ratio
There is some evidence suggesting that OSA is associated with low level of systemic inflammation and oxidative stress. Low level systemic inflammation and subsequent vascular damage has been implicated as the underlying mechanism…
- Trial name
- NCT02272608
- Testing
- Evaluation of Sleep Apnea Related Inflammation with CRP, ESR and Neutrophil toLymphocyte Ratio
- Volunteers
- 279 people
- Sponsor
- Ordu University
OSA
Continuation Protocol for Obstructive Sleep Apnea (OSA)
The combination drug composed of aroxybutynin and atomoxetine, designated AD109, is being developed by Apnimed for the treatment of obstructive sleep apnea (OSA).
- Trial name
- NCT06566820
- Testing
- Aroxybutynin and Atomoxetine
- Where
- 99 sites in United States, Canada
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- Apnimed
Insomnia, Randomised Controlled Trial
Buddhist Awareness Training Program and Qigong Psychosocial Interventions for People With Insomnia
This study aims to compare the efficacy of the Mahayana Buddhist Awareness Training Program (ATP) with a Qigong group in treating people with insomnia in Hong Kong.
- Trial name
- NCT06910423
- Testing
- Psychosocial intervention
- Where
- Hong Kong
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- College of Professional and Continuing Education Limited
Obstructive Sleep Apnea
Anxiety and Depression In Patients With Obstructive Sleep Apnoea Before and After Continuous Positive Airway Pressure
Continuous positive airway pressure (CPAP) is the gold-standard treatment for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing in the overall population.
- Trial name
- ADIPOSA (NCT04104880)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Granada
Obese, Sleep Apnea, Obstructive
Nutritional Rehabilitation and Sleep Apnea in the Obese
In obese patients, the prevalence of obstructive sleep apnea (OSA) is around 40% in men and 30% in women. Weight loss after bariatric surgery significantly improves OSA, with 75% of patients having a reduction in OSA severity or…
- Trial name
- DIETSLEEP (NCT03857191)
- Testing
- Nutritional psychocomportemental rehabilitation
- Where
- France
- Volunteers
- 396 people
- Sponsor
- University Hospital, Grenoble
Obstructive Sleep Apnea
BASET Scoring: A Novel Simple Biometric Score and Potential Tool for Diagnosis and Grading of Obstructive Sleep Apnea Syndrome (OSAS) Patients
this study aims to assess the validity of BASET scoring as a new potential tool for diagnosis and grading the severity of OSAS patients and as screening of the risk factors of OSAS.
- Trial name
- BASET (NCT05511974)
- Testing
- BASET score
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Mansoura University
Insomnia, Chronic Pain
The Young Adult Clinic (YAC) Study
The overarching aim of the Young Adult Clinic (YAC) study is to evaluate the DOZE app, a digital, transdiagnostic behavioral sleep medicine and self-management approach in young adult patients (ages 18-25) with chronic pain.
- Conditions
- Insomnia, Chronic Pain, Insomnia Due to Medical Condition
- Trial name
- YAC (NCT05147974)
- Testing
- DOZE app
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Women's College Hospital
Chronic Insomnia
Impact of Suvorexant on Sympathetic Nerve Activity and Baroreflex Function in Chronic Insomnia
This study aims to evaluate the effect of Suvorexant on sympathetic nerve activity and baroreflex function in subject with chronic insomnia.
- Trial name
- NCT03768713
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Montana State University
Sleep Apnea Syndromes
Cloud Based Follow up of CPAP Treatment
Obstructive sleep apnea (OSA) is treated with a continuous positive airway pressure, so called CPAP. A new technology that enables telemetric monitoring of CPAP therapy.
- Trial name
- NCT03446560
- Testing
- CPAP, conventional follow up, CPAP, telemedicine based follow up
- Where
- Sweden
- Volunteers
- 403 people
- Sponsor
- Vastra Gotaland Region
Obstructive Sleep Apnea
Vitamin D and SGLT-2 Inhibitor in CPAP-naive Obstructive Sleep Apnea
The purpose of this study is to determine if vitamin D supplement and SGLT-2 inhibitor treatment combination can improve cardiovascular risks in patients with OSA and hypertension, on top of lifestyle modification, before…
- Trial name
- D3DOSA (NCT06690723)
- Testing
- Dapagliflozin (Forxiga), Vitamin D3 ( Colecalciferol), Vitamin D3 plus Dapagliflozin
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- University Malaysia Sarawak
Obstructive Sleep Apnea (OSA)
Direct Referral for Apnea Monitoring
The primary objective of this project is to compare a health care delivery model, Direct Referral for Apnea Monitoring (DREAM), with initial in-person (Traditional) clinic appointments for Veterans at risk for obstructive sleep…
- Trial name
- DREAM (NCT05419323)
- Where
- 3 sites in United States
- Volunteers
- 6,501 people
- Sponsor
- VA Office of Research and Development
Fibromyalgia Syndrome, Fibromyalgia
Effects of 2-Aticyto Complex and D-Ribose on Pain and Clinical Course in Patients With Fibromyalgia
This multicenter, randomized, double-blind, placebo-controlled study will evaluate whether an oral supplement containing 2-Aticyto Complex and D-ribose (FibroThol), added to ongoing standard medical treatment, improves pain…
- Trial name
- NCT07495943
- Testing
- 2-Aticyto Complex and D-ribose Oral Supplement
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Narcolepsy With Cataplexy, Healthy Controls
Xyrem and Brain Dopamine in Narcolepsy
The overall aim of this investigation is to establish whether an action of Xyrem® on the brain dopamine system in patients with narcolepsy, and in a comparison control group, might explain part of the anti-narcoleptic effect of…
- Trial name
- NCT02637076
- Testing
- Xyrem
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Sleep Apnea, Obstructive, Hypertension, Pulmonary
Auto-PAP for Pulmonary Hypertension Treatment in Decompensated HF Patients With Sleep Apnea.
The objective of the study is to evaluate the effect of continuous positive airway pressure (PAP) therapy on pulmonary arterial (PA) pressures in acute decompensated heart failure (HF) patients with obstructive sleep apnea (OSA).
- Conditions
- Sleep Apnea, Obstructive, Hypertension, Pulmonary, Heart Failure
- Trial name
- ASAP-HF (NCT02963597)
- Testing
- AirSense™ 10 AutoSet, Standard Medical Therapy
- Where
- 2 sites in United States, Germany
- Volunteers
- 21 people
- Sponsor
- Albert Einstein Healthcare Network
Sleep Apnea Syndrome, Obstructive, Sleep Apnea Syndrome (OSAS)
Botulinum Toxin in the Palatopharyngeal Muscle for the Treatment of Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is a sleep-related breathing disorder characterized by recurrent collapse of the upper airway during sleep, in which the palatopharyngeal muscle plays a key role in pathophysiology.
- Conditions
- Sleep Apnea Syndrome, Obstructive, Sleep Apnea Syndrome (OSAS), Sleep Apnea/Hypopnea Syndrome, Sleep Apnea - Obstructive
- Trial name
- ARAP1 (NCT07399782)
- Testing
- BOTULINUM TOXIN IN THE PALATOPHARYGEUS MUSCLE
- Volunteers
- 20 people
- Sponsor
- Hospital Felicio Rocho