Clinical trials: Sleep Disorders, Intrinsic
Insomnia, Depression/Anxiety
Use of CBT-I Based Chatbot for Assisted Treatment in Patients With Insomnia
The recent lifestyle has put many people in a state of high stress, and the outbreak of COVID-19 in recent years has caused a steady increase in the number of people diagnosed with "Coronasomnia" (Covid-somnia) after recovering…
- Trial name
- NCT07021625
- Testing
- Kunbot, Treatment as usual
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Taipei Medical University WanFang Hospital
Cardiovascular Diseases, Cardiovascular Diseases Risk
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk assessment beyond conventional single-purpose ambulatory rhythm…
- Conditions
- Cardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular Abnormalities
- Trial name
- Cor360 (NCT07775976)
- Testing
- COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Obesity Hypoventilation Syndrome (OHS)
Study of AD981 Versus Placebo in Obesity Hypoventilation Syndrome
This is a randomized, double blind, placebo-controlled, cross-over, phase II, single center efficacy study of AD981 in patients with obesity hypoventilation syndrome documented by polysomnography (PSG) and transcutaneous…
- Trial name
- ATOHS (NCT05448443)
- Testing
- AD981
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Auxologico Italiano
Cancer, Insomnia
Survivorship Sleep Program
This is a randomized pilot trial to test the feasibility and acceptability (primary outcomes) of a virtual cognitive behavioral program for insomnia for survivors of various cancer types.
- Trial name
- NCT04566068
- Testing
- Intervention- Adapted Virtual Insomnia Program, Control- Enhanced usual care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Fibromyalgia
Fibromyalgia Treatment Trial With Gabapentin and Osteopathic Manipulative Medicine
This study assesses the benefits of intervention with gabapentin, Osteopathic Manipulative Medicine or both for improvement of the symptoms of Fibromyalgia.
- Trial name
- FTTGO (NCT01107574)
- Testing
- Gabapentin, Osteopathic Manipulative Medicine, Gabapentin and Osteopathic Manipulative Medicine
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Good Samaritan Regional Medical Center, Oregon
Insomnia
E-aid Cognitive Behavior Therapy for Insomnia to Prevent Transition From Acute Insomnia to Chronic Insomnia in China
Acute insomnia is one of the most common sleep disorders. Online cognitive behavioral therapy for insomnia (e-aid Cognitive Behavioral Therapy for Insomnia, eCBTI) has received wide attention in recent years.
- Trial name
- NCT03302455
- Testing
- eCBTI
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Excessive Daytime Sleepiness, Parkinson Disease
BEN-2001 in Parkinson Disease Patients With Excessive Daytime Sleepiness
This phase 2b study is designed as multicentre, multinational, randomized, double blind, parallel group and placebo controlled with three doses of Bavisant (0.5, 1, and 3 mg/d) in subjects with excessive daytime sleepiness with…
- Trial name
- CASPAR (NCT03194217)
- Testing
- BEN-2001
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- BenevolentAI Bio
Sleep Initiation and Maintenance Disorders
Bioequivalence and Food Effect Study in Healthy Volunteers
The purpose of this study is to select the formulation with the optimal pharmacokinetic profile for an hypnotic drug to further develop in the market.
- Trial name
- NCT00495274
- Testing
- Formulation A, Formulation B, Formulation C
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sildenafil, Sleep Apnea
The Effect of Sildenafil on Sleep-Disordered Breathing in Obese Patients With Sexual Dysfunction
Sildenafil has been shown to aggravate sleep-disordered breathing in patients with severe obstructive sleep apnea. The aim of the present study is to examine the frequency of sleep-disordered breathing in obese patients who are…
- Conditions
- Sildenafil, Sleep Apnea, Sexual Dysfunction, Obesity
- Trial name
- NCT00893191
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Restless Legs Syndrome
A Study to Evaluate the Efficacy and Safety of Cabergoline Compared With Placebo for the Treatment of RLS
The purpose of this study is to evaluate the efficacy and safety of cabergoline compared with placebo on periodic leg movements (PLMS) arousl index and sleep efficiency in patients with RLS.
- Trial name
- NCT00627003
- Testing
- Cabergoline
- Volunteers
- 43 people
- Sponsor
- Pfizer
OSA - Obstructive Sleep Apnea
SMARTPHONE APPLICATION HOME-BASED EXERCISES IN OBSTRUCTIVE SLEEP APNEA IN JEDDAH
The study aim is to explore the effects of a home-based exercise training smartphone application on sleep quality, fatigue, functional capacity, and quality of life among obstructive sleep apnea (OSA) patients in Jeddah city…
- Trial name
- NCT06954974
- Testing
- CPAP device, CPAP device and exercise, Exercise
- Volunteers
- 60 people
- Sponsor
- King Abdulaziz University
Restless Legs Syndrome
Survey on Long-Term Use of BI-Sifrol® Tablets in Patients With Restless Legs Syndrome
The survey is conducted to investigate the safety and efficacy of long-term use of BI-Sifrol Tablets in Restless Legs Syndrome (RLS) patients with or without renal dysfunction in routine medical practice.
- Trial name
- NCT01174459
- Where
- 159 sites in Japan
- Volunteers
- 571 people
- Sponsor
- Boehringer Ingelheim
Insomnia Chronic
STATE Trial: SusTained Attention Training to Enhance Sleep - Remote
This study is a validation study to document the acceptability of the Tonic and Phasic Alertness Training (TAPAT) program in older adults with chronic late-life insomnia.
- Trial name
- STATE (NCT03604380)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Active Comparator
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Posit Science Corporation
Obstructive Sleep Apnea Syndrome
Treatment of Patients With the Obstructive Sleep Apnea Syndrome at Altitude
The purpose of the study is to investigate the effect of acetazolamide as a treatment for sleep related breathing disturbances in patients with the obstructive sleep apnea syndrome living at low altitude during a sojourn at…
- Trial name
- NCT00714740
- Testing
- acetazolamide
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Stress, Anxiety
Stress Resilience Training System
The Stress Resilience Training System (SRTS) program is a stress reduction and resilience building system that blends cognitive training to anticipate the effects of stress with advanced biofeedback to mitigate stress effects and…
- Conditions
- Stress, Anxiety, Depression, PTSD
- Trial name
- SRTS (NCT01599624)
- Testing
- Stress Resilience Training System (SRTS), Progressive Muscle Relaxation (PMR)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Knee Osteoarthritis; Insomnia; Cervical Spondylosis; Chronic Low Back Pain; Allergic Rhinitis
Validating Blinding Maintenance of a Sham-Sensitization Control Design for Sensitization Acupuncture Trials
This study is the clinical validation component of a broader research program developing a randomized controlled trial (RCT) comparing sensitization acupuncture (an individualized technique in which treatment points are selected…
- Trial name
- NCT07868224
- Testing
- Sensitization Acupuncture, Traditional Acupuncture
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Prion Disease
PrP-targeting siRNA Safety & Mechanism Study
The purpose of this trial is to evaluate safety, tolerability, pharmacokinetics and pharmacodynamic impact of PrP-siRNA in symptomatic prion disease patients and in pre-symptomatic adults at genetic risk for prion disease.
- Trial name
- PRiSM (NCT07444580)
- Testing
- PrP-siRNA
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- Broad Institute of MIT and Harvard
Sleep Apnea, Obstructive
Predictive Factors for Prescribing a Mandibular Advancement Device for the Treatment of Obstructive Sleep Apnea
This project evaluates the morphological predictive factors for prescribing a mandibular advancement device in the therapeutic approach of Obstructive sleep apnea (OSA).
- Trial name
- NCT05677620
- Testing
- Pharyngeal Computed Tomography, Drug-Induced Sleep Endoscopy (Propofol), Mandibular Advancement Device
- Where
- Portugal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Insomnia
Sleep Management in Cancer Survivors
The pilot project will investigate three short-term intervention programs for sleep management in cancer survivors in a randomized controlled clinical study. Three programs to be examined in the study are: 1.
- Trial name
- NCT00935376
- Testing
- Sleep Education Program, Mind-Body Bridging Program, Mindfulness Meditation Program
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Utah
Chronic Kidney Diseases, OSAS (Obstructive Sleep Apneas Syndrome)
The Outcome of Chronic Kidney Disease Patients With Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea (OSA) is highly prevalent in chronic kidney disease (CKD) patients and strongly linked to obesity, metabolic syndrome, and type 2 diabetes.
- Trial name
- NCT06971874
- Testing
- No intervention
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Nanfang Hospital, Southern Medical University
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