Clinical trials: Sleep Disruption
Treatment Resistant Depression
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information…
- Trial name
- DNS-ECT (NCT05905705)
- Testing
- Electroencephalography (EEG), Quantitative Measurements of Sleep Microstructure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Pregnancy, Postpartum Period
Sleep Disruption in New Mothers: An Intervention Trial
The purpose of this study is to test a behavioral intervention to minimize sleep disruption and fatigue in new mothers after the birth of their first infant.
- Conditions
- Pregnancy, Postpartum Period, Sleep Disturbance
- Trial name
- MOMS (NCT01321710)
- Testing
- Sleep hygiene, Dietary information, Acetaminophen
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- University of California, San Francisco
Schizophrenia
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia
The proposed study has been planned to evaluate the effect of add-on ramelteon on sleep pattern/quality and circadian rhythm disruption in patients with schizophrenia.
- Trial name
- NCT03075657
- Testing
- Risperidone, Risperidone and Ramelteon, Haloperidol
- Where
- India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Intensive Care Unit (ICU), Sleep Disruption
Impact on Prognosis of Increased Sleep Quality Obtained by Personalized Night-time Nursing Care in Critically Ill Patients
Sleep disturbances are common among intensive care unit (ICU) patients and have been associated with difficult weaning from invasive mechanical ventilation, with an increased risk of endotracheal intubation.
- Conditions
- Intensive Care Unit (ICU), Sleep Disruption, Sleep Monitoring
- Trial name
- MEDICOSLEEP (NCT07606495)
- Testing
- Sleepscan device, Sleep-guided nursing care
- Where
- 7 sites in France
- Volunteers
- 460 people
- Sponsor
- Poitiers University Hospital
Patients With Drug-resistant Focal Epilepsy, SEEG as Part of Presurgical Evaluation
Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep
Interactions between epilepsy and sleep are numerous and bidirectional. Sleep can facilitate epileptic activity and seizures in several syndromes, while sleep deprivation increases cortical excitability and seizure…
- Trial name
- EPIDREAM 3 (NCT07605858)
- Testing
- Direct Electric Stimulation (DES)
- Where
- 2 sites in United States, France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Apnea of Prematurity
Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study
Apnea of prematurity is a common condition that is usually treated with methylxanthines. Methylxanthines are adenosine receptor blockers that have powerful influences on the central nervous system.
- Trial name
- CAP-S (NCT01020357)
- Testing
- Caffeine citrate injection
- Where
- 4 sites in Australia, Canada
- Volunteers
- 201 people
- Sponsor
- McMaster University
Feeding Patterns, Sleep
The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU
The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic…
- Conditions
- Feeding Patterns, Sleep, Glucose Intolerance
- Trial name
- NCT04737200
- Testing
- Time-of-day of enteral nutrition provision (daytime first), Time-of-day of enteral nutrition provision (nighttime first)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Sleep Deprivation, Pain
Mechanisms of Sleep Disruption Hyperalgesia
Twenty percent of Americans suffer from chronic pain. Sleep disturbance is similarly prevalent and among the most common and disabling neurobehavioral problems associated with chronic pain.
- Trial name
- ESP2 (NCT01794689)
- Testing
- Morphine, Forced Awakenings, Uninterrupted Sleep
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Disturbance, Critical Illness
Sleep Quantity and Quality in the ICU: a Prospective Observational Stud
Several evidences in the literature suggest sleep interruption in critical care patients. Nowadays, the amount and the quality of sleep phases during the length of stay in the intensive care unit are largely unknown.
- Trial name
- NCT03796338
- Testing
- Sleep Profiler
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Careggi Hospital
Hypertension
Real-World Validation for Less-Disturbing Ambulatory Blood Pressure Monitoring (ABPM) in Malaysia Using Huawei Wearables
Background: Ambulatory Blood Pressure Monitoring (ABPM) is the gold standard for diagnosing high blood pressure (hypertension) because it tracks blood pressure continuously across day and night.
- Trial name
- Huawei-SunU2 (NCT07790978)
- Where
- Malaysia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sunway University
Circadian Rhythm Disorders
Managing Sleep-wake Disruption Due to Hospitalisation: the Circadian Care Project
Sleep is regulated by the interaction of homeostatic and circadian processes. The homeostatic process determines sleep propensity in relation to sleep-wake history, the circadian one is responsible for the alternation of high/low…
- Trial name
- CircadianCare (NCT05228444)
- Testing
- CircadianCare
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University Hospital Padova
Breast Neoplasms
Exploring Biological Linkage Between Circadian Disruption and Cancer Progression
The purpose of this study is to explore the possible association between the circadian disruption and cancer progression.
- Trial name
- NCT02011815
- Where
- South Korea
- Volunteers
- 236 people
- Sponsor
- Seoul National University Hospital
Sleep Disorders, Stress
COPing With Shift Work - Web Based Program for Police Officers
This study is a clinical trial in which 300 Police Officers who currently work midnight shifts in the participating police departments will be recruited to test the effectiveness of a new web-based program to address sleep and…
- Trial name
- NCT02240082
- Testing
- Web-Based COPing with Shiftwork Program
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- ISA Associates, Inc.
Bilateral Salpingo-oophorectomy
Sleep in Women With Bilateral Salpingo-Oophorectomy
The purpose of this research study is the compare objective and subjective sleep characteristics in women who have undergone removal of both ovaries (bilateral salpingo-oophorectomy) before natural menopause compared to women who…
- Trial name
- NCT04565158
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sleep, Circadian Rhythm
Impact of Sleep Disruption on the Menstrual Cycle
The purpose of this study is to investigate whether sleep disruption affects menstrual cycle timing
- Conditions
- Sleep, Circadian Rhythm, Menstrual Cycle
- Trial name
- NCT00456222
- Testing
- Disrupting or changing the timing or the duration of sleep
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders
Light Exposure to Treat Sleep Disruption in Older People
The purpose of this study is to test whether shifts in the timing of the biological clock to a later hour (phase delay shifts of the human circadian system) can be produced in response to four successive evenings of light…
- Conditions
- Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia
- Trial name
- NCT00427323
- Testing
- light exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Traumatic Brain Injury
Optimized Sleep After Brain Injury: Sleep Hygiene Intervention After Traumatic Brain Injury
OSABI is a pilot study of a sleep hygiene protocol for sleep disruptions associated with TBI during inpatient rehabilitation. Twenty participants will be allocated (by minimization) either into a standard of care protocol or a…
- Trial name
- OSABI (NCT02838082)
- Testing
- Sleep Hygiene Protocol, Standard of Care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Craig Hospital
Delayed Sleep Phase Disorder
Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD)
Delayed Sleep Phase Disorder (DSPD) is a sleep disruption that commonly occurs in teens and manifests as a difficulty in waking up in the morning, going to sleep early enough at night, and daytime disturbances such as depression…
- Trial name
- NCT01406691
- Testing
- Flashes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Obstructive Sleep Apnea, Sleep
Impact of Exogenous Ketones on Sleep Apnea
Obstructive Sleep Apnea (OSA) is a common medical disorder that is associated with reduced quality of life and higher risk of cardiovascular disease. Treatments for OSA and limited and not well tolerated.
- Trial name
- KETO-SLEEP 2 (NCT06687655)
- Testing
- Ketone-IQ
- Where
- United States
- Sponsor
- Johns Hopkins University
Low Back Pain, Sleep Disruption
Effects of Mattress Firmness on Pain in Patients With Chronic Low-Back Pain
The primary study objective is to determine whether mattress firmness affects pain in patients with chronic low-back pain. We hypothesize that mattresses that differ in their firmness and support should have a varying effect on…
- Trial name
- NCT01044121
- Testing
- Mattress Firmness
- Volunteers
- 40 people
- Sponsor
- Sleep To Live Institute