Clinical trials: Sleep Disturbances and Insomnia
Insomnia
VEC-162 Study in Healthy Adult Volunteers in a Model of Insomnia
The purpose of this study is to determine the safety and efficacy of VEC-162 compared to placebo to improve sleep parameters in a model of insomnia.
- Trial name
- NCT00291187
- Testing
- 20 mg VEC-162, 50 mg VEC-162, 100 mg VEC-162
- Where
- 19 sites in United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Insomnia Disorder
A Study of Daridorexant in Chinese Patients With Insomnia Disorder
The primary purpose of this study is to assess the efficacy and safety of 50 mg daridorexant in adult and elderly chinese patients with insomnia disorder. Efficacy will be evaluated on objective and subjective sleep parameters .
- Trial name
- NCT06010693
- Testing
- Daridorexant
- Where
- 33 sites in China
- Volunteers
- 206 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Insomnia
A Study to Evaluate Next-Dose Transition From Zolpidem to Lemborexant (LEM) for the Treatment of Insomnia
The primary objective of the study is to evaluate the proportion of adult [greater than or equal to (>=) 18 years] participants with insomnia disorder taking zolpidem tartrate immediate release (ZOL-IR) or zolpidem tartrate…
- Trial name
- NCT04009577
- Testing
- LEM 5 mg, LEM 10 mg
- Where
- 17 sites in United States
- Volunteers
- 53 people
- Sponsor
- Eisai Inc.
Primary Insomnia
Adult Primary Insomnia Polysomnographic Study (0928-004)(COMPLETED)
The purpose of the study is to test the safety and effectiveness of the Investigational Drug on insomnia.
- Trial name
- NCT00094627
- Testing
- gaboxadol
- Volunteers
- 465 people
- Sponsor
- H. Lundbeck A/S
Primary Insomnia
A Prospective Active-Reference Study of Gaboxadol in Primary Insomnia
To evaluate the efficacy safety and tolerability of gaboxadol in primary insomnia
- Trial name
- NCT00209937
- Testing
- Gaboxadol
- Volunteers
- 675 people
- Sponsor
- H. Lundbeck A/S
Chronic Insomnia
Subjective Efficacy of Ramelteon on Sleep in Adults With Chronic Insomnia.
The purpose of this study is to determine the subjective treatment effects of ramelteon, once daily (QD), on sleep using a post sleep questionnaire-interactive voice response system in adults with chronic insomnia.
- Trial name
- NCT00414102
- Testing
- Ramelteon
- Where
- 52 sites in United States
- Volunteers
- 552 people
- Sponsor
- Takeda
Sleep Initiation and Maintenance Disorders
A Study to Evaluate the Safety of DAYVIGO (Lemborexant) Tablets in Participants With Insomnia.
The purpose of the study is to evaluate the incidence of somnolence, parasomnia, narcoleptic symptoms, and suicidal ideation/suicidal behavior after administration of lemborexant (DAYVIGO) in daily practice.
- Trial name
- NCT04573556
- Testing
- Lemborexant
- Where
- 3 sites in Japan
- Volunteers
- 550 people
- Sponsor
- Eisai Co., Ltd.
Sleep Initiation and Maintenance Disorders
Efficacy Study of EVT 201 to Treat Insomnia
The purpose of this study is to determine whether a compound known as EVT 201 is effective in treating people diagnosed with primary insomnia ( difficulty sleeping with no other significant contributing factor, such as…
- Trial name
- NCT00380003
- Testing
- EVT 201
- Where
- 5 sites in United States
- Volunteers
- 66 people
- Sponsor
- Evotec Neurosciences GmbH
Insomnia
Stilnox Treatment in Elderly Patients With Insomnia
Primary objective: 1. To evaluate the efficacy of Zolpidem 5mg for 1 week in elderly patients with insomnia in China Secondary objectives: 1.
- Trial name
- STEP (NCT00359229)
- Testing
- Zolpidem
- Volunteers
- 115 people
- Sponsor
- Sanofi
Sleep Initiation and Maintenance Disorders
Randomised, Double-blind Study to Investigate the Safety and Efficacy of Brotizolam in Insomnia Outpatients.
To investigate the efficacy and safety of Brotizolam in the treatment of patients with insomnia in comparison with that of Estazolam
- Trial name
- NCT00347295
- Testing
- Brotizolam, Estazolam
- Where
- 8 sites in China
- Volunteers
- 253 people
- Sponsor
- Boehringer Ingelheim
Insomnia, Sleep
Vestibular Nerve Stimulation to Improve Sleep
A randomized, double blind sham controlled clinical trial to evaluate the efficacy of vestibular nerve stimulation (VeNS) compared to a sham control a as a means of improving sleep as measured by ISI scores and EEG recordings The…
- Conditions
- Insomnia, Sleep, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT04219566
- Testing
- VeNS
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Neurovalens Ltd.
Sleep Disturbance, Insomnia
The CANabidiol Use for RElief of Short Term Insomnia
This study aims to investigate the effect of 50 mg and 100 mg per day oral CBD product versus a placebo over 8 weeks on insomnia severity in adults aged 18-65 years old with insomnia symptoms.
- Conditions
- Sleep Disturbance, Insomnia, Insomnia Type; Sleep Disorder, Insomnia, Transient
- Trial name
- CANREST (NCT05253417)
- Testing
- 50 mg Cannabidiol (CBD), 100 mg Cannabidiol (CBD)
- Where
- 2 sites in Australia
- Volunteers
- 208 people
- Sponsor
- Bod Australia
Insomnia, Attention Deficit Hyperactivity Disorder
Long Term Safety Study of Study Drug (Eszopiclone) in Children and Adolescents With ADHD -Associated Insomnia
A multicenter study to evaluate the safety of eszopiclone in children (6 11 years of age, inclusive) and adolescents (12 17 years of age, inclusive) with attention deficit/hyperactivity disorder (ADHD) associated insomnia.
- Trial name
- NCT00857220
- Testing
- eszopiclone
- Where
- 89 sites in United States
- Volunteers
- 304 people
- Sponsor
- Sumitomo Pharma America, Inc.
Sleep Initiation and Maintenance Disorders, Insomnia
Efficacy and Safety of Eplivanserin Treatment for Sleep Maintenance Insomnia
The purpose of the study is to assess efficacy and safety of eplivanserin in the population of patients complaining of sleep maintenance insomnia.
- Trial name
- GEMS (NCT00253968)
- Testing
- Eplivanserin
- Where
- 12 sites in United States, Argentina and 10 more
- Volunteers
- 967 people
- Sponsor
- Sanofi
Sleep Apnea, Obstructive
Safety of Ramelteon in Subjects With Mild to Moderate Obstructive Sleep Apnea
The purpose of this study is to assess the safety of ramelteon, once daily (QD), in individuals with obstructive sleep apnea.
- Trial name
- NCT00672061
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Takeda
Primary Insomnia
Subjective Study to Assess the Efficacy of APD125 in Patients With Sleep Maintenance Insomnia
This study is designed to compare 2 doses of APD125 (20 mg and 40 mg) with placebo in otherwise healthy adults with primary insomnia primarily with complaints of maintaining sleep.
- Trial name
- NCT00664664
- Testing
- APD125
- Where
- United States
- Volunteers
- 744 people
- Sponsor
- Arena Pharmaceuticals
Transient Insomnia
An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia
The purpose of this study is to assess the efficacy and pattern of use of the combination drug product SM-1 in adults who sometimes have difficulty in falling asleep or staying asleep, but who do not have chronic insomnia.
- Trial name
- NCT03338764
- Testing
- SM-1
- Sponsor
- Sequential Medicine Ltd
Schizophrenia, Insomnia
Trial Evaluating Paliperidone Extended-Release (ER) Tablets Versus Placebo on Sleep in Schizophrenia Patients
The primary objective of this study is to evaluate the amelioration of the sleep architecture of patients with schizophrenia and schizophrenia-related insomnia, treated with either 9 mg of extended-release paliperidone ER or…
- Trial name
- NCT00105326
- Testing
- paliperidone ER
- Volunteers
- 5 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Insomnia
STATE Trial: SusTained Attention Training to Enhance Sleep
This study is a validation study to document the acceptability of the Tonic and Phasic Alertness Training (TAPAT) training program in older adults with chronic late-life insomnia.
- Trial name
- STATE (NCT02921074)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Posit Science Corporation
Insomnia
A Phase III Study of Eszopiclone in Patients With Insomnia (Study SEP 190-150)
The purpose of this study is to evaluate the long-term safety of eszopiclone (2, 3 mg) in non-elderly patients with insomnia and eszopiclone (1, 2 mg) in elderly patients with insomnia.
- Trial name
- NCT00770692
- Testing
- Eszopiclone 1 mg- Elderly, Eszopiclone 2 mg- Elderly, Eszopiclone 3 mg- Non-elderly
- Where
- 34 sites in Japan
- Volunteers
- 369 people
- Sponsor
- Eisai Co., Ltd.