Clinical trials: Sleep Hypopnea
Ischemic Stroke, Cerebral Infarct
Consequences of Post Stroke Polysomnographic Abnormalities on Functionnal Recovery and Survival After an Ischemic Stroke
Ischemic stroke is a major public health issue, likely to cause functional disability. It is well known that sleep has an impact on brain plasticity, and after an ischemic stroke, studies have shown subjective sleep quality…
- Conditions
- Ischemic Stroke, Cerebral Infarct, Sleep Apnea, Periodic Limb Movement Disorder
- Trial name
- PSG-AVC (NCT04816136)
- Testing
- Sleep recording (already done)
- Where
- France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Montpellier
Obstructive Sleep Apnea, Morbid Obesity
Epigenetics Modifications in Morbid Obesity and Obstructive Sleep Apnea Patients: The EPIMOOSA Study
This study evaluates epigenetics in morbid obese patients who are waiting for bariatric surgery. A home cardiopulmonary polygraphy is performed to evaluate for the presence of sleep-disordered breathing.
- Conditions
- Obstructive Sleep Apnea, Morbid Obesity, Epigenetic Disorder
- Trial name
- EPIMOOSA (NCT03995836)
- Testing
- CPAP, Bariatric Surgery
- Volunteers
- 70 people
- Sponsor
- Aragon Institute of Health Sciences
OSA
Pharyngeal Muscle Control Mechanisms of Atomoxetine-plus-oxybutynin in Obstructive Sleep Apnea
Current therapies available for obstructive sleep apnea (OSA) have varying degrees of efficacy due to the complex nature of the disorder.
- Trial name
- NCT05944965
- Testing
- Atomoxetine 80 mg plus Oxybutynin 5 mg, Atomoxetine 80 MG
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hypertension, Obstructive Sleep Apnea
Impact of Sleep-Disordered Breathing Management in Systemic Hypertension Control: METASLEEP Project
Hypertension is a frequent condition affecting 11M Spanish citizens and is the leading modifiable contributor to cardiovascular disease and death.
- Trial name
- NCT05986487
- Testing
- CPAP or usual practice, Monitoring and intervention in follow-up
- Where
- Spain
- Volunteers
- 1,523 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Obstructive Sleep Apnea
Outcome of Laser or Debrider Tonsillotomy Versus Tonsillectomy in Obstructive Sleep Apnea
Tonsil surgery for children suffering from obstructive sleep apnea have significant post operative morbidity including pain and occasionally bleeding. This morbidity is partly caused by post surgical inflammation.
- Trial name
- TVLOD (NCT01319058)
- Testing
- Tonsillectomy, laser tonsillotomy, debrider tonsillotomy
- Where
- Israel
- Volunteers
- 88 people
- Sponsor
- Soroka University Medical Center
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS), Head and Neck Cancers
Innovative OSA Screening in Head and Neck Cancer Patients With the Apneal App
Obstructive sleep apnea syndrome is a common but often underdiagnosed condition, with significant impacts on quality of life, such as fatigue, attention disorders, and an increased risk of heart attack or stroke.
- Trial name
- NCT06896448
- Testing
- Specialized sleep consultation and overnight recording using the APNEAL application
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Obstructive Sleep Apnea
Bi-lateral HGN Therapy in Real-World Patients -Post Approval Research Investigation
The objective of the BREATHE study is to demonstrate the continued safety and effectiveness of the Genio® System in treating subjects diagnosed with moderate to severe obstructive sleep apnea (OSA) who are intolerant to or…
- Trial name
- BREATHE (NCT07331285)
- Testing
- This is a single arm study, all consented and eligible subjects will be implanted with the Genio® System 2.1
- Where
- 2 sites in United States
- Volunteers
- 229 people
- Sponsor
- Nyxoah Inc.
Sleep Apnea, Obstructive
Novel Auto-continuous Positive Airway Pressure (CPAP) Validation
This single-blind randomised crossover trial aims to compare the efficacy of a novel Auto-CPAP algorithm (SPAP) to conventional CPAP. Up to 50 patients will be recruited from an OSA population, aged over 18.
- Trial name
- NCT01943708
- Testing
- SPAP, CPAP
- Where
- New Zealand
- Volunteers
- 74 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Predictive Value of Sleep Apnea-specific PTT Response for Incident Subclinical Abnormalities in LV Structure and Function in Cohort of moderate-to Severe OSA
This observational study aims to provide evidence for identifying those who mostly suffer from LV injury and will help construct an optimal strategy for clinical practice.
- Trial name
- NCT06626906
- Testing
- Echocardiography, Blood sampling for biomarker assays
- Volunteers
- 376 people
- Sponsor
- Xu J
Sleep, Sleep Apnea
Research Framework Exploring Sleep Health
This is a digital health study in which participants are recruited to collect sleep and activity data from digital activity trackers.
- Conditions
- Sleep, Sleep Apnea, Obesity, Mood
- Trial name
- REFRESH (NCT05197738)
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Narcolepsy, Obstructive Sleep Apnea (OSA)
Study of Psychological, Sociological and Professional Factors Associated With Maintenance of Wakefulness Test
The predictors of objective impaired alertness assessed by Maintenance of Wakefulness Tests (MWT) are poorly understood. Identifying such predictors are essential from a clinical point of view and from a pathophysiological…
- Trial name
- STAYAWAKE (NCT06586138)
- Testing
- STAI (State-Trait Anxiety Inventory) Scale : Psychological inventory of 20 self-report items on a 4-point scale
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Hospices Civils de Lyon
Sleep Apnea, Obstructive
Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome.
Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To assess the total or partial recovery of oxidative and inflammatory damage after recovering IH.
- Trial name
- NCT04444778
- Testing
- CPAP
- Where
- 2 sites in Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Alberto Alonso Fernandez
Obstructive Sleep Apnea
Simulated In-House Usability Study of Eclipse Continuous Positive Airway Pressure (CPAP) Device
The study is designed to assess the usability of a novel CPAP human interface compared to a traditional nasal mask. Human subjects will interact with two different CPAP interfaces including a traditional CPAP mask and the 2nd…
- Trial name
- NCT05570747
- Testing
- Usability
- Where
- 3 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Bleep, LLC
Severe Sleep Apnea, Severe Insomnia
Mainstream Sleep Tracking Devices vs Polysomnography
The purpose of this study is to compare two popular portable sleep monitoring devices-the Fitbit Charge®, Jawbone UP®, and SleepTime smartphone app-to the "gold standard" Polysomnography (PSG).
- Conditions
- Severe Sleep Apnea, Severe Insomnia, Epileptiform Activity
- Trial name
- NCT02744235
- Testing
- Polysomnography Data, Jawbone UP®, Fitbit Charge ®
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Obstructive Sleep Apnea Syndrome, Temporomandibular Disorders
Side Effects of Mandibular Advancement Devices
Sleep-related breathing disorders (SBAS) are one of the most common causes of non-restorative sleep. Sleep therapy options include positive pressure ventilation with continuous positive airway pressure (CPAP) masks, mandibular…
- Trial name
- NCT04050514
- Testing
- H-MAD with a hinge system according to Herbst
- Where
- 9 sites in Germany
- Volunteers
- 65 people
- Sponsor
- University Medicine Greifswald
Obstructive Sleep Apnea
SleepFlexTM Treatment of Obstructive Sleep Apnea
The purpose of this study is to evaluate the safety and effectiveness of the SleepFlex program for treatment of mild to moderate OSA
- Trial name
- NCT04726514
- Testing
- SleepFlex
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Berendo Scientific, LLC
Atrial Fibrillation, Obesity
SORT - AF Supervised Obesity Reduction Trial for AF Ablation Patients
Study hypothesis: Weight reduction in obese patients with atrial fibrillation. Obese patients benefit from an obesity treatment after atrial fibrillation ablation. Study design: A prospective randomized, open-label clinical trial.
- Conditions
- Atrial Fibrillation, Obesity, Sleep Apnea
- Trial name
- SORT-AF (NCT02064114)
- Testing
- Intervention group, control group
- Where
- 4 sites in Germany
- Volunteers
- 142 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Obstructive Sleep Apnea (OSA)
Correlation Endoscopic View of Airway Obstruction With RRa in OSA Patients Under DEX Monitored With SedLine EEG
Patients with obstructive sleep apnea (OSA) could have several anatomical causes of obstruction. A sleep endoscopy study is a technique to help determine the anatomical cause of OSA.
- Trial name
- NCT02639884
- Testing
- SedLine EEG, RRa monitoring
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Masimo Corporation
Obstructive Sleep Apnea (OSA)
The Efficacy of a New Mathematical Formula to Predict Continuous Positive Air Pressure With an Oronasal Mask Interface.
Subjects will all have a two week baseline period in which they will use a nasal mask using an air view CPAP machine (which records all data).
- Trial name
- NCT02816255
- Testing
- Full Face Mask with same CPAP Pressure, Full Face Mask with new Pressure
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Weill Medical College of Cornell University
Obstructive Sleep Apnea
Pulse Oximeter for Sleep Evaluation
The investigators will conduct this study to validate Belun Ring for sleep assessment. The investigators will compare Belun Ring data collection and overnight in-lab polysomnography (PSG) measures of SDB and sleep architecture in…
- Trial name
- ROSA (NCT04612114)
- Testing
- Belun Ring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
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