Clinical trials: Sleep Hypopnea
Sleep Disordered Breathing, Drug Induced Sleep Disorder
DISE in Pediatric Sleep Disordered Breathing
Adenotonsillar hypertrophy is the most common reason for children to have sleep disordered breathing (SDB). Even though adenotonsillectomy improves sleep apnea in children, 20-40% of children will still have persistent SDB.
- Trial name
- NCT06756971
- Testing
- Propofol, Dexmedetomidine
- Sponsor
- University of Iowa
Obstructive Sleep Apnea, Postoperative Pain
Effect of Sleep Apnea on Pain After Dental Treatment
This observational study aims to investigate the effects of sleep quality and systemic health status on pain levels following endodontic treatment in adult patients.
- Conditions
- Obstructive Sleep Apnea, Postoperative Pain, Hypertension Complicated With Type 2 Diabetes
- Trial name
- OSA-EndoPain (NCT07581964)
- Testing
- Standard Endodontic Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Harran University
Obstructive Sleep Apnea Syndrome
Efficacy of Oral Leukotriene in Long Term Therapy of Mild and Moderate Obstructive Sleep Apnea Syndrome in Children
The aim of the project is to evaluate whether therapy with leukotriene may be a valid therapeutic approach in children with adenotonsillar hypertrophy and with mild and moderate obstructive sleep apnea syndrome (OSAS) and to…
- Trial name
- SB-OSAS (NCT00912171)
- Testing
- budesonide (Aircort 50 nasal spray), montelukast (Singulair)
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Bologna
OSA
Continuous Positive Airway Pressure Use in Asthma With Moderate to Severe Obstructive Sleep Apnea Patients
Obstructive sleep apnea syndrome (OSAS) and asthma are both common disorders in Hong Kong, with prevalence of at least 4% among the middle-aged male Hong Kong (HK) Chinese populations and 7.2% in young adults respectively.
- Trial name
- OSA (NCT01383564)
- Testing
- CPAP group, non CPAP group
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Comparison of Demographic Data Mentioned by the Patients or Measured by a Physician
OSA (Obstructive Sleep Apnea) represents a major risk of postoperative complications. Predictive scores have been developed as the STOP-Bang score and the DES-OSA score.
- Trial name
- NCT05709964
- Testing
- Self-reported, Measured
- Where
- Belgium
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Astes
Obstructive Sleep Apnea
Neuromodulation Therapy Device for the Treatment of Sleep Apnea
We are looking to test a novel device in the treatment of Obstructive Sleep Apnea (OSA). Rather than using positive pressure to open the airways, we are testing a device that delivers an auditory tone to affect neuromodulation.
- Trial name
- NCT01117064
- Testing
- Neuromodulation Therapy Device (NMTD)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea
App-Based Optimization of Long-Term CPAP Adherence and Quality of Life
The purpose of this study is to optimize the time of CPAP usage to at least 6 hours a night for 6 nights per week for people who have OSA with the help of a smartphone application called SmartWell24.
- Trial name
- NCT06381115
- Testing
- SleepWell24 Application
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Hypertension, Cardiac Arrhythmias
Clinical Trial in Patients With Hypertension and Left Ventricular Dysfunction
Arterial hypertension causes adverse effects on the entire cardiovascular system, with effects centrally such as diastolic dysfunction and structural changes of the left ventricle and, peripherally such as endothelial dysfunction…
- Conditions
- Hypertension, Cardiac Arrhythmias, Diabetes Mellitus, Renal Insufficiency
- Trial name
- NCT02148991
- Where
- 2 sites in Greece
- Volunteers
- 100 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Obstructive Sleep Apnea of Adult
Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA)
The goal of this clinical trial is to learn if melatonin works to treat comorbid insomnia in adults with OSA and nocturnal non-dipping blood pressure pattern.
- Trial name
- MEBP-OSA (NCT06380491)
- Testing
- Melatonin 3 MG Oral Tablet
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Cardiac Diseases, Muscular Weakness
Biomarker for Pompe Disease (BioPompe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Pompe disease from blood (plasma)
- Conditions
- Cardiac Diseases, Muscular Weakness, Hepato-splenomegaly, Lung Disease
- Trial name
- BioPompe (NCT01457443)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Heart Failure, Central Sleep Apnea
Central Sleep Apnea Prevalence and Impact on Cognitive Function in Patients With Heart Failure With Reduced or Mildly Reduced Left Ventricular Ejection Fraction
Study to assess the prevalence of central sleep apnea in patients with heart failure with reduced or mildly reduced left ventricular ejection fraction (LVEF <50%) followed by case-control study to assess the link between central…
- Trial name
- COG01 (NCT06313840)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Zoll Medical Corporation
Acute Respiratory Failure, Hypercapnic Respiratory Failure
Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation
This study compares a volume targeted pressure support non-invasive ventilation with an automatic PEP regulation (AVAPS-AE mode) to a pressure support non-invasive ventilation (S/T mode) in patients with acute hypercapnic…
- Conditions
- Acute Respiratory Failure, Hypercapnic Respiratory Failure, Respiratory Acidosis, Obesity
- Trial name
- VONIVOO (NCT04131660)
- Testing
- AVAPS-AE mode during NIV, S/T mode during NIV
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Rouen
Sleep Apnea, Obstructive
Prescision Medicine in Obstructive Sleep Apnea, Cardiovascular and Cerebrovascular Disease: AI Electrocardiogram Patch Does it All
Obstructive Sleep apnea(OSA) is a disease with multiple causes, and treatments are very diverse. Patients and doctors have a lot of choices.
- Trial name
- NCT05566860
- Testing
- Positional Therapy, Intraoral Negative Pressure Therapy, Oral Appliances
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Obstructive Sleep Apnea, Insomnia
Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA
The comorbidity between obstructive sleep apnea (OSA) and insomnia (COMISA) is common, and associated with poorer sleep quality. CPAP adherence among COMISA patients is worst than among those with OSA only.
- Trial name
- NCT06017921
- Testing
- Eszopiclone 3 mg
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Sleep Apnea, Heart Failure
Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure
Sleep Apnea (SA) is a disorder that causes pauses in breathing during sleep that expose the heart to oxygen deprivation. It is common in patients with heart failure (HF) where it is associated with increased risk of…
- Trial name
- ADVENT-HF (NCT01128816)
- Testing
- Adaptive Servo Ventilation
- Where
- 49 sites in United States, Brazil and 7 more
- Volunteers
- 732 people
- Sponsor
- Toronto Rehabilitation Institute
Sleep Apnea
Treating Sleep Apnea in Women Veterans
This study is a randomized controlled trial (RCT) to test two sleep apnea education programs for women Veterans newly diagnosed with sleep apnea (SA) who are prescribed positive airway pressure (PAP) therapy.
- Trial name
- NCT03377452
- Testing
- Acceptance and the Behavioral Changes to Treat Sleep Apnea (ACB-SA), Non-directive sleep apnea education control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- VA Office of Research and Development
Sleep Apnea Syndrome
Effect of Early Education on the Observance of CPAP Treatment
Sleep apnea (SA) affects more than 4% from general population and is largely underdiagnosed. SA can increase the occurrence of cardiovascular, endocrine and metabolic events (particularly stroke, diabetes \& obesity).
- Trial name
- CoachSAS (NCT02657304)
- Testing
- Coaching group, Control group
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea
FIBRotic Interstitial Lung Disease and Nocturnal OXygen
Home sleep studies - which allow the measurement of breathing while the person sleeps - will be performed on patients with fibrotic interstitial lung disease attending two of the UK's largest respiratory medicine services.The…
- Conditions
- Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea, Sleep Disturbance, Sleep Hypoventilation
- Trial name
- FIBRINOX (NCT04586946)
- Where
- 2 sites in United Kingdom
- Volunteers
- 102 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obstructive Sleep Apnea
Evaluation of Post-surgical Improvement in OSA Patients After Imaging of Upper Airway Using CBCT and DISE vs DISE Only
CBCT is considered an innovative imaging modality that can view the upper respiratory airway anatomy in a 3D manner. Recent studies tried to evaluate the accuracy of CBCT in analyzing the upper respiratory airway and its related…
- Trial name
- NCT04727346
- Testing
- CBCT, DISE
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obstructive Sleep Apnea
Modified Anterior Palatoplasty In Obstructive Sleep Apnea Syndrome
The aim of this study is to evaluate the effectiveness of barbed suture modification of anterior palatoplasty in the treatment of patients with retropalatal mild to moderate obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT04572503
- Testing
- Barbed Suture Modified Anterior Palatoplasty
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Benha University
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