Clinical trials: Sleep Hypopnea
Obstructive Sleep Apnea (OSAS)
Evaluation of Respiratory Muscle Sarcopenia in Obstructive Sleep Apnea Syndrome
OSAS is a disease characterized by repeated interruptions and restarts of breathing during sleep. Respiratory muscle sarcopenia is a condition in which the muscle strength of the diaphragm and other respiratory auxiliary muscles…
- Trial name
- RMS-OSAS (NCT06783998)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Tarsus University
Respiratory Failure, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory Failure
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients admitted to hospital with acute exacerbation of chronic respiratory failure.
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01174316
- Testing
- AutoVPAP™, VPAPIIIST-A™
- Where
- United Kingdom
- Sponsor
- ResMed
Sleep Apnea, Overweight and Obesity
CPAP, Nutrition & Exercise Against Sleep Apnea
This study evaluates the addition of a comprehensive lifestyle program including dietary management and exercise to continuous positive airway pressure (CPAP) therapy in overweighted adults with obstructive sleep apnea.
- Trial name
- TINE (NCT03959280)
- Testing
- Tailored intervention, Control
- Where
- 2 sites in France, Switzerland
- Volunteers
- 120 people
- Sponsor
- Raphael Heinzer
Obstructive Sleep Apnea
Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea
The current study combines two treatments for obstructive sleep apnea (OSA), oral appliances and supplemental inspired oxygen. The following aims will be tested: Aim 1.
- Trial name
- NCT03189173
- Testing
- Oral appliance, Oxygen, Oral appliance plus oxygen
- Where
- 2 sites in United States, Australia
- Volunteers
- 41 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea, Spinal Cord Injuries
Overnight Upper Airway Infiltration in Spinal Cord Injury
Obstructive Sleep Apnea (OSA), a common disorder resulting from repetitive pharyngeal collapse during sleep, is multifactorial. Usually, OSA is considered primarily a problem of upper airway anatomy, with the craniofacial…
- Trial name
- OUI-SCI (NCT05391308)
- Testing
- Pre-polysomnography mesurement, Polysomnography measure, Post-polysomnography measurements
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea
Long Term Prognosis of Taiwanese Patients With OSA
The purpose of this study is to explore long-term prognosis and to identify the predictors in Taiwanese OSA patients. Validation of the prediction model derived from NHIRD with the database of National Taiwan University Hospital…
- Trial name
- NCT02090023
- Where
- Taiwan
- Volunteers
- 4,000 people
- Sponsor
- National Taiwan University Hospital
Obstructive Sleep Apnea of Adult
Baseline Sleep Apnea Study #2
This is a single group, unblinded, prospective clinical study. This study seeks to understand patient diagnostic and treatment journey and positive airway pressure (PAP) therapy compliance for Verily Sleep Apnea (VSA) program/app…
- Trial name
- NCT04599803
- Testing
- Verily Sleep Apnea (VSA) Program/App
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Verily Life Sciences LLC
Respiratory Failure Chronic, Obesity Hypoventilation Syndrome
Myocardial Effects of NIV in OHS Patients
Chronic effects of noninvasive ventilation on myocardial function in patients with obesity hypoventilation syndrome (OHS) are scarcely understood.
- Conditions
- Respiratory Failure Chronic, Obesity Hypoventilation Syndrome, Obstructive Sleep Apnea, Cardiac Output, Low
- Trial name
- NCT06486129
- Testing
- Noninvasive ventilation volume targetted
- Where
- Slovakia
- Volunteers
- 13 people
- Sponsor
- Pavol Jozef Safarik University
OSA COPD Overlap Syndrome
Comparing Two Types of Breathing Support in People With COPD, High Carbon Dioxide Levels, and Sleep Apnea
This pilot study compares two positive airway pressure strategies for patients with both COPD and obstructive sleep apnea (overlap syndrome) who retain excess carbon dioxide.
- Trial name
- PAVE-OVS (NCT07891962)
- Testing
- high-intensity ventilation strategy, OSA-targeted ventilation strategy
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Sleep Apnea
Italian PheNotypes Obstructive Sleep Apnea Study
Obstructive Sleep Apnea (OSA) is the most common sleep-related breathing disorder, representing a major socioeconomic burden on healthcare systems worldwide.
- Trial name
- IPNOS (NCT06872242)
- Testing
- Polysomnography
- Where
- 30 sites in Italy
- Volunteers
- 5,000 people
- Sponsor
- Istituto Auxologico Italiano
Obstructive Sleep Apnea, Tonsillar Hypertrophy
Tonsillectomy vs. Tonsillotomy in Adults With Obstructive Sleep Apnea
The primary purpose of this randomized controlled trial s to investigate whether surgical reduction of palatine tonsils (tonsillotomy) is a superior treatment compared to complete surgical removal of palatine tonsils…
- Trial name
- NCT06376383
- Testing
- Tonsillectomy, Tonsillotomy
- Volunteers
- 464 people
- Sponsor
- University of Aarhus
Obstructive Sleep Apnea
SLEEP AND OSA ON REPRODUCTIVE FUNCTION IN MEN
In view of the hormonal changes induced by both sleep deprivation and obstructive sleep apnea syndrome (OSA), and the importance of maintaining these hormones in reproductive processes.
- Trial name
- PSAR01 (NCT01884454)
- Testing
- Sleep deprivation
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Obstructive Sleep Apnea
A Randomized Cross Over Trial of Two Treatments for Sleep Apnea in Veterans With Post-Traumatic Stress Disorder
Sleep disturbances are cardinal features of Veterans with post traumatic stress disorder (PTSD). In particular, obstructive sleep apnea is reported to occur more frequently in patients with PTSD compared to those without PTSD and…
- Trial name
- NCT01569022
- Testing
- CPAP, MAD
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea
A Study Of Synthetic THC And Sleep
The purpose of this study is to determine if oral dronabinol prior to sleep can improve CPAP adherence and sleep quality in humans.
- Trial name
- NCT07570953
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Mounier-Kuhn Syndrome
Airway Collapse in Patients With Mounier-Kuhn Syndrome: Titration With Positive Pressure to Reduce Collapse
Mounier-Kuhn syndrome (MKS), or congenital tracheobronchiomegaly, is an entity characterized by dilation of the trachea and bronchi, associated with respiratory infections.The main signs and symptoms are cough, bulging and…
- Trial name
- NCT03101059
- Testing
- Non invasive ventilation - Continuous Positive Airway Pressure
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo General Hospital
Sleep Apnea
Evaluation of New Diagnostic and Treatment Algorithm for Obstructive Sleep Apnea
Newer home sleep study device and algorithm provides an alternative for inpatient sleep study and improve the service provides to patients
- Trial name
- NCT00425659
- Testing
- home sleep study, home CPAP titration (Autoset), CPAP
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Urinary Leukotriene E4 Levels in Children With Obstructive Sleep Apnea
Investigate urinary leukotriene E4 levels and determine if there is a correlation with severity of obstructive sleep apnea. The investigators then would like to determine a threshold level which could then be used for…
- Trial name
- NCT02205346
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Eastern Virginia Medical School
Sleep Apnea, Obstructive, Sleep Apnea Syndromes
Continuous Positive Airway Pressure (CPAP) After Adenotonsillectomy in Children
Obstructive sleep-disordered breathing (SDB) affects 2-3% of children and may lead to problems with nighttime sleep and daytime behavior, learning, sleepiness, and mood.
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Child Behavior Disorders, Attention Deficit Disorder With Hyperactivity
- Trial name
- NCT01554527
- Testing
- CPAP treatment, No CPAP treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Michigan
Sleep Apnea
Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study C
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Models to study mechanisms of airway collapse have been proposed.
- Trial name
- NCT01738022
- Testing
- Administration of gas mixtures
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Evaluation of the F&P Caramel Nasal Mask, US, 2023
The purpose of this clinical investigation is to evaluate the performance and safety of the F\&P Caramel nasal mask in a home environment.
- Trial name
- NCT06060717
- Testing
- F&P Caramel
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
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