Clinical trials: Sleep Hypopnea
Obstructive Sleep Apnoea (OSA)
Feasibility of Upper Airway Stimulation in OSA
Project Breathe 1 is a short-duration (5 month) pilot investigation to assess the safety and tolerability of non-invasive electrical stimulation in adults with obstructive sleep apnoea.
- Trial name
- NCT07396649
- Testing
- Non-invasive electrical stimulation
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Notos Medical Limited
PCOS, PCOS (Polycystic Ovary Syndrome)
PMOS in OSA Pilot Study
The goal of this study is to obtain pilot data investigating the effects of sleep apnea on mitochondrial function and cellular metabolism in Polyendocrine Metabolic Ovarian Syndrome (PMOS) patients.
- Conditions
- PCOS, PCOS (Polycystic Ovary Syndrome), OSA, OSA - Obstructive Sleep Apnea
- Trial name
- NCT07871149
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Sleep Apnea, Obstructive; Post-Traumatic Stress Disorders
Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder
Obstructive sleep apnea (OSA) has traditionally been attributed only to a collapsible upper airway. However, it is increasingly recognized that multiple additional non-anatomical mechanisms contribute to the disease.
- Trial name
- NCT02699138
- Testing
- Trazodone, Epiglottic catheter
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cystic Fibrosis, Hirschprung's Disease
Evaluating the Alimentary and Respiratory Tracts in Health and Disease (EARTH) Research Program.
The investigators have established the "Evaluating the Alimentary and Respiratory Tracts in Health and disease" (EARTH) research program.
- Conditions
- Cystic Fibrosis, Hirschprung's Disease, Obstructive Sleep Apnea, Healthy
- Trial name
- EARTH (NCT04071314)
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Obstructive Sleep Apnea
Improving Older Adults' Decision Making for OSAT
This study evaluates the feasibility of conducting a randomized controlled trial that tests a patient decision aid for obstructive sleep apnea in older adults with newly-diagnosed obstructive sleep apnea treated in an outpatient…
- Trial name
- eDecide2Rest (NCT03138993)
- Testing
- Patient decision aid, General sleep education
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, Los Angeles
Mild Obstructive Sleep Apnea
Therapy of Oral Appliance for Adults Jordanians With Obstructive Sleep Apnea
Introduction: Obstructive Sleep Apnea (OSA) is the most common form of sleep disordered breathing. Patients who arrive at the dental office with a diagnosis of OSA are often treated with a mandibular advancement device (MAD).
- Trial name
- TOAAJOSA (NCT05087316)
- Testing
- biomimetic oral appliance therapy (BOAT), Standard hospital treatment
- Where
- Jordan
- Volunteers
- 17 people
- Sponsor
- Jordan University of Science and Technology
Polycystic Ovary Syndrome (PCOS), Obstructive Sleep Apnea
Sex Steroids, Sleep, and Metabolic Dysfunction in Women
Increased plasma triglyceride concentration is a common feature of the metabolic abnormalities associated with obesity and a major risk factor for cardiovascular disease.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Obstructive Sleep Apnea, Obesity
- Trial name
- SCOR (NCT00805207)
- Testing
- Progesterone, testosterone, glucocorticoid
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obstructive Sleep Apnea
New Perspective on Exploring the Post-apneic BP Surge in Patients With OSA
The nocturnal short-term BPV induced by sleep-breathing events is affected by many factors. The purpose of the study is as follows: (1) to explore the relationship between nocturnal short-term BPV and vascular endothelial…
- Trial name
- NCT06172998
- Testing
- Phentolamine Injection
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Xu J
Perennial Allergic Rhinitis, Obstructive Sleep Apnea
The Effects of Mometasone Furoate Nasal Spray in Subjects With Sleep-disordered Breathing (SDB) Associated With Perennial Allergic Rhinitis (Study P04726)
This is a Phase 4 randomized, placebo-controlled, parallel-group, single-center, double-blind study to evaluate the effects of mometasone furoate nasal spray (MFNS) in subjects with Sleep-disordered Breathing (SDB) associated…
- Conditions
- Perennial Allergic Rhinitis, Obstructive Sleep Apnea, Sleep Disorder
- Trial name
- NCT00359216
- Testing
- Mometasone furoate nasal spray
- Volunteers
- 30 people
- Sponsor
- Organon and Co
Anesthesia, Anesthesia Complication
Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk
Light to moderate sedation is recommended during surgery with spinal anesthesia . This study is exploring which sedation drug is better, midazolam or dexmedetomidine for transurethral resection of bladder and prostate in patients…
- Conditions
- Anesthesia, Anesthesia Complication, Osa Syndrome, Transurethral Resection of Prostate
- Trial name
- NCT04817033
- Testing
- Spinal anesthesia with intraoperative dexmedetomidine sedation, Spinal anesthesia with intraoperative midazolam sedation, Dexmedetomidine
- Where
- Croatia
- Volunteers
- 115 people
- Sponsor
- University Hospital of Split
Parkinson's Disease, Obstructive Sleep Apnea
Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease
This trial will assess whether long-acting levodopa taken at night improves obstructive sleep apnea (OSA) in patients with Parkinson's disease (PD), as compared with placebo.
- Trial name
- NCT03111485
- Testing
- Sinemet CR
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Obstructive Sleep Apnea Syndrome
Follow-up Studies of Primary Snoring(PS) and Obstructive Sleep Apnea Hypopnea Syndrome(OSAHS) in Chinese Children
The study is designed to investigate the natural course of Primary snoring in 1-2 years or more and the different effect of drug and surgical treatment applied in children with obstructive sleep apnea (OSAS) by comparing the…
- Trial name
- NCT02447614
- Testing
- Adenotonsillectomy, Conservative treatment, no treatment
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Children's Hospital
Sleep Apnea, Obstructive, Hypertension Secondary
Efficiency of Speech Therapy in Resistant Hypertensive Patients With Mild Obstructive Sleep Apnea Syndrome
The purpose of this study is to analyze the effect of speech therapy on quality of life, sleep quality, daytime sleepiness level and apnea-hypopnea index in patients with hypertensive patients with mild obstructive apnea syndrome.
- Trial name
- NCT03753633
- Testing
- Speech therapy, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Obstructive Sleep Apnea
Australian Clinical Study of the Apnex Medical HGNS System to Treat Obstructive Sleep Apnea
The overall goal of the study is to evaluate the safety, efficacy and therapy settings of the HGNS System for stimulating the hypoglossal nerve to help maintain an open airway in subjects with obstructive sleep apnea (OSA).
- Trial name
- NCT01186926
- Testing
- HGNS Treatment
- Volunteers
- 40 people
- Sponsor
- Apnex Medical, Inc.
Obstructive Sleep Apnea (OSA)
The ATLAST Long-Term Study
The Study is a multi-center, prospective, open label, single-arm, three-month, long-term study of the Attune Sleep Apnea System for the treatment of obstructive sleep apnea (OSA).
- Trial name
- NCT01476917
- Testing
- Attune Sleep Apnea System
- Where
- 6 sites in United States
- Volunteers
- 39 people
- Sponsor
- ApniCure, Inc.
Obstructive Sleep Apnea of Adult, Acute Coronary Syndrome
OSA-ACS Project: Association of OSA and CPAP Therapy With Outcomes in ACS Patients
Obstructive sleep apnea (OSA) is an increasingly common chronic disorder in adults that has been strongly associated with various forms of cardiovascular disease.
- Trial name
- NCT03362385
- Testing
- Patients with OSA based on sleep study, Patients without OSA based on sleep study
- Where
- China
- Volunteers
- 2,160 people
- Sponsor
- Beijing Anzhen Hospital
Obstructive Sleep Apnoea (OSA)
Breath Analysis in Obstructive Sleep Apnoea
Clinical trial in patients with obstructive sleep apnoea that are randomised to either continue or withdraw continuous positive airway pressure therapy to identify a disease-specific exhaled breath pattern by mass spectrometry.
- Trial name
- NCT02050425
- Testing
- CPAP
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Sleep Apnea, Healthy
Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences
The overall goal of this project is to better understand the effect of intermittent hypoxia (IH) on sympathetic neuronal discharge patterns in humans, as well as mechanisms that mediate persistent sympathoexcitation with IH.
- Conditions
- Sleep Apnea, Healthy, Vasoconstriction, Vasodilation
- Trial name
- NCT05146089
- Testing
- Hypoxic exposure, modified Oxford test, Oral Bosentan 62.5 mg
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Sleep-Disordered Breathing
Pediatric Adenotonsillectomy Trial for Snoring
The purpose of this study is to evaluate the effects of early adenotonsillectomy (eAT) on the behavior, sleep-disordered breathing symptoms and quality of life for children who snore, but do not have obstructive sleep apnea, as…
- Trial name
- PATS (NCT02562040)
- Testing
- Early Adenotonsillectomy (eAT), Watchful Waiting with Supportive Care (WWSC)
- Where
- 7 sites in United States
- Volunteers
- 459 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
This research study is designed to learn, first, whether two anesthetics have different effects on collapse seen within the upper airway during sleep endoscopy.
- Trial name
- NCT05303987
- Testing
- Propofol sedation, Dexmedetomidine sedation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Erin Kirkham
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