Clinical trials: Sleep Hypoventilation
COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS)
Assessment of Breathing Pattern During NIV
COPD and OHS are respiratory conditions that disrupt normal breathing. Positive airway pressure, specifically Non-Invasive Ventilation (NIV), has been shown to improve breathing and reduce symptoms in patients with these…
- Trial name
- NCT06682286
- Testing
- NIV mask A, NIV mask B
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Fisher and Paykel Healthcare
Obesity Hypoventilation Syndrome (OHS)
Obesity in Sleep Medicine - Focusing on OHS Phenotypes
This study focuses on a comprehensive examination of obese patients with sleep-related breathing disorders including patients with OSA, sleep hypoventilation and OHS.
- Trial name
- NCT04570540
- Testing
- Sleep Study, Pulmonary Function Test, Hypercapnic ventilatory response
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Obesity-hypoventilation Syndrome, Nocturnal Alveolar Hypoventilation
Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -
Investigate whether the course of an isolated nocturnal alveolar hypoventilation can predict the future occurrence of obesity-hypoventilation syndrome (OHS) in obese subjects
- Trial name
- NCT02021448
- Testing
- Annual visits among 3 years. During each visit different testings are performed in order to detect an obesity-hypoventilation syndrome (OHS)
- Where
- 6 sites in France
- Volunteers
- 188 people
- Sponsor
- University Hospital, Strasbourg, France
Sleep Apnea
Opiate Sleep Disordered Breathing Study
Lay title: A study of breathing pauses during sleep in patients on long term opiates. Sleep apnoea is a term which refers to frequent breathing pauses during sleep.
- Trial name
- NCT00791674
- Where
- 2 sites in Australia
- Volunteers
- 50 people
- Sponsor
- Adelaide Institute for Sleep Health
Sleep Apnea Syndromes in Children, Obesity in Children
Overview: Use of Respiratory Support At Home in Children
the primary outcome is to describe the perceived success of the use of the respiratory support from the parent's point of view
- Conditions
- Sleep Apnea Syndromes in Children, Obesity in Children, Bronchopulmonary Dysplasia (BPD), Neuromuscular Disease
- Trial name
- ELIPSE (NCT06692660)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Respiratory Failure, Neuromuscular Disease
Ventilator Monitoring in Early Exacerbation Detection
The aim of this study is to determine whether respiratory disease exacerbations (a sudden worsening of symptoms) can be predicted by variables that are monitored by non-invasive ventilators (small machines that assist breathing)…
- Conditions
- Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01644162
- Testing
- iVAPS ventilation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- ResMed
Obesity Hypoventilation Syndrome (OHS), Hypoventilation
Effects of Exercise Training on Exercise Capacity and Sleep Quality in Patients With Obesity Hypoventilation Syndrome
Obesity Hypoventilation Syndrome is defined as a combination of obesity (BMI ≥ 30 kg/m2) and daytime hypercapnia in arterial blood gas analysis (PaCO2 > 45 mmHg) without other pathologies that cause hypoventilation.
- Conditions
- Obesity Hypoventilation Syndrome (OHS), Hypoventilation, Obesity, Respiration Disorders
- Trial name
- NCT05398068
- Testing
- Exercises and Diet, Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Intermittent Positive-pressure Ventilation, Respiratory Physiological Phenomena
Impact of Non-intentional Leaks on Noninvasive Ventilation
The investigators hypothesized that increasing non intentional leaks could increase work of breathing and could lead to patient/non-invasive ventilation (NIV) asynchrony.
- Trial name
- NIV-Leaks (NCT00983411)
- Testing
- Non intentional leaks during non invasive ventilation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AGIR à Dom
Obesity Hypoventilation Syndrome (OHS)
Study of AD981 Versus Placebo in Obesity Hypoventilation Syndrome
This is a randomized, double blind, placebo-controlled, cross-over, phase II, single center efficacy study of AD981 in patients with obesity hypoventilation syndrome documented by polysomnography (PSG) and transcutaneous…
- Trial name
- ATOHS (NCT05448443)
- Testing
- AD981
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Auxologico Italiano
Central Alveolar Hypoventilation Syndrome
PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood
Detect the PHOX2B Mutation-confirmed congenital central hypoventilation syndrome
- Trial name
- NCT00652964
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Obesity Hypoventilation Syndrome, Chronic Respiratory Failure
Cost Effectiveness of Outpatient Set-up of Automated NIV in Obese Patients With Chronic Respiratory Failure
Obesity is an escalating issue, with an accompanying increase in referrals of patients with obesity-related respiratory failure.
- Trial name
- OPIP (NCT02342899)
- Testing
- Outpatient NIV Set Up using AVAPS AE (Manufactured by Philips-Respironics), Inpatient NIV Set Up using spontaneous/timed (S/T) mode pressure support ventilation (Manufactured by Philips-Respironics)
- Where
- 6 sites in France, United Kingdom
- Volunteers
- 82 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Neuromuscular Disorders, Chest Wall Disorders
Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern
The purpose of this study is to determine whether breathing pattern (specifically the inspiratory time/total respiratory cycle value) has an influence over the response to the noninvasive mechanical ventilation.
- Conditions
- Neuromuscular Disorders, Chest Wall Disorders, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- NCT01991535
- Testing
- Spontaneous Ventilation Mode, Controlled Ventilation Mode, Simulator Ventilation Mode
- Where
- Spain
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Insomnia Disorder
Virtual Reality Relaxation for Insomnia
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effects of a virtual reality (VR) relaxation intervention among adults aged 25 to 50 with insomnia disorder.
- Trial name
- NCT07630532
- Testing
- Virtual reality relaxation intervention
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Obesity Hypoventilation Syndrome (OHS)
HVNI Versus NIV In Management Of Acute Hypercapnic Respiratory Failure In OHS
1. Assessment of benefits of HVNI in management of obesity hypoventilation syndrome complicated with acute hypercapnic respiratory failure. 2.
- Trial name
- NCT05805293
- Testing
- High-Velocity Nasal Insufflation Therapy, Non-Invasive Ventilation
- Volunteers
- 56 people
- Sponsor
- Assiut University
Obesity, Obesity Hypoventilation Syndrome
Factors Associated With Chronic Respiratory Failure in Obesity
Some overweight individuals develop problems with their breathing such that they gradually breathe less and less. This leads to a lack of oxygen and a buildup of carbon dioxide in the blood, called ventilatory failure.
- Trial name
- NCT01380418
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- Oxford University Hospitals NHS Trust
Cystic Fibrosis
Sleep in Patients With Cystic Fibrosis
The aim of the study is to identify the parameters that are associated with nocturnal hypoventilation in children and adults with cystic fibrosis.
- Trial name
- Sommeil (NCT00804661)
- Testing
- SENTEC device
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myotonic Dystrophy, Steinert
Factors Associated With Hypoventilation in the Myotonic Dystrophy, Progressive Profile Over 5 Years
The aim of this study is to determine the factors associated with alveolar hypoventilation in terms of cognitive impairment, daytime sleepiness, respiratory function, nocturnal respiratory events This evaluation will clarify the…
- Trial name
- Steinert (NCT03764150)
- Where
- 6 sites in France
- Volunteers
- 113 people
- Sponsor
- University Hospital, Lille
Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome
Treatment of Metabolic Alkalosis With Acetazolamide. Effect on the Length of Mechanical Ventilation.
The purpose of this study is to analyze whether the treatment of metabolic alkalosis with acetazolamide in intubated patients with chronic obstructive pulmonary disease (COPD) or with obesity hypoventilation syndrome (OHS)…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Obesity Hypoventilation Syndrome, Metabolic Alkalosis
- Trial name
- TRAMA (NCT01499485)
- Testing
- Acetazolamide
- Where
- 8 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Hospital Son Llatzer
Obesity Hypoventilation Syndrome
PAP Therapy in Patients With Obesity Hypoventilation Syndrome
The role of different levels of compliance and long-term effects of positive airway pressure (PAP) therapy on gas exchange, sleepiness, quality of life, depression and death rate in patients with obesity hypoventilation syndrome…
- Trial name
- NCT03449641
- Testing
- Positive airway pressure (PAP)
- Volunteers
- 252 people
- Sponsor
- University of Crete
Sleep Apnea, Alveolar Hypoventilation
How Differences in Oximeter Performance May Affect Clinical Decision
In clinical practice discrepancies between overnight SpO2 recordings performed by 2 devices used simultaneously are regularly observed. However, this has not been systematically studied or quantified.
- Conditions
- Sleep Apnea, Alveolar Hypoventilation, Nocturnal Hypoxemia
- Trial name
- NCT04474574
- Testing
- Simultaneous recording of nocturnal SpO2
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Geneva