Clinical trials: Sleep Impairment
Sleep Restriction, Impaired Glucose Metabolism
The Effects of Modafinil to Counteract the Adverse Metabolic Consequences of Sleep Restriction
The purpose of the study is to examine the effects of sleep and modafinil on how the body processes glucose.
- Trial name
- NCT00895570
- Testing
- modafinil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
PreDiabetes, Overweight
Night Owl Metabolism
The proposed study uses a novel and rigorous randomized cross-over study design in youth (18-23y) with late and non-late chronotype (n=35 per group) to assess the glycemic effect of "aligning" an oral glucose tolerance test…
- Conditions
- PreDiabetes, Overweight, Impaired Glucose Tolerance
- Trial name
- NCT06507722
- Testing
- Timing of OGTT, Timing of Standardized Meal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dementia, Mild Cognitive Impairment
HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study will investigate the validity of the HOGAR EEG/PSG monitoring kit designed by Bitbrain as a tool for characterizing and assessing cognitive function in older adults, as well as for detecting and predicting cognitive…
- Conditions
- Dementia, Mild Cognitive Impairment, Dementia Alzheimers, Dementia, Mixed
- Trial name
- Hogar (NCT06993207)
- Testing
- Home Lab
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bitbrain
Parkinson Disease
Gait, Physical Activity, and Sleep in Parkinson's Disease
This study aims to investigate the relationship between balance and gait impairments, physical activity levels, and sleep status in individuals with Parkinson's disease (PD).
- Trial name
- NCT07424924
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Biruni University
Obstructive Sleep Apnea
Potential Mechanism of Exercise Impairment in OSA
Obstructive sleep apnea (OSA) is a common disorder with major cardiovascular sequelae. A recent study confirmed that OSA is associated with impaired exercise capacity and increasing OSA severity predicts worsening exercise…
- Trial name
- NCT02505594
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Sleep Wake Disorders, Sleep Disturbance
Optimizing Cardiac Rehabilitation by Integrating Sleep Therapeutics
The study aims are to: 1) optimize the Transdiagnostic Sleep and Circadian Intervention (TranS-C) for delivery to Veterans in cardiac rehabilitation, 2) test and refine the adapted TranS-C treatment manual and protocol, and 3)…
- Conditions
- Sleep Wake Disorders, Sleep Disturbance, Sleep-Related Impairment
- Trial name
- NCT04506112
- Testing
- Transdiagnostic Sleep and Circadian Intervention (TranS-C), adapted for cardiac rehabilitation
- Where
- United States
- Sponsor
- VA Office of Research and Development
Impaired Attention
Evaluation of the Sleep-relieving Effect of Banana Peel Extract
Banana peel has the potential to improve sleep quality. The purpose of this research is to test the effect of banana peel on improving sleep quality.
- Trial name
- NCT05130359
- Testing
- Banana peel extract
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Cognitive Therapy/Methods, Insomnia Chronic
Memory Training in Insomnia With Cognitive Impairment
This randomized controlled trial investigates the effects of Cognitive Remediation Therapy (CRT) on chronic insomnia (CI) with mild cognitive impairment.
- Conditions
- Cognitive Therapy/Methods, Insomnia Chronic, Cognitive Dysfunction
- Trial name
- NCT06969066
- Testing
- Cognitive Remediation Therapy plus Sleep Hygiene Education (CRT+SHE), Sleep Hygiene Education Only (SHE)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuanwu Hospital, Beijing
HIV - Human Immunodeficiency Virus, Insomnia Disorder
A Sleep Program to Improve Sleep Quality in People With HIV
Sleep problems, such as insomnia, are more frequent and intense in individuals living with HIV. These sleep difficulties can increase the difficulties in thinking and concentrating.
- Trial name
- NCT02571595
- Testing
- Digital cognitive behavioural therapy for insomnia (dCBT-I)
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- McGill University
Insomnia
Low-intensity Cognitive-behavioural Therapy for Insomnia
A randomized controlled trial is proposed to compare the effectiveness of workshop-based and self-Help cognitive behavioral therapy for insomnia (CBTI), and sleep hygiene education (SHE) to treat insomnia in Hong Kong adolescent…
- Trial name
- NCT03736694
- Testing
- Cognitive behavioural therapy for insomnia, Sleep hygiene education
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment, Sleep
Home Sleep Therapy for Older Adults With MCI
The goal of this clinical trial is to learn about the ability of non-invasive brain stimulation during sleep to enhance people's deep sleep and its potential benefit on memory in people with mild cognitive impairment via home use…
- Conditions
- Mild Cognitive Impairment, Sleep, Transcranial Electrical Stimulation, Machine Learning
- Trial name
- NCT05771844
- Testing
- Transcranial Electrical Stimulation
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brain Electrophysiology Laboratory Company
Sleep Architecture, Sleep Disorders
Sleep, Cognition and Memory Disorder
The increasing incidence of Alzheimer's disease (AD) and related sleep-disorders with the aging of the population is a major issue of public health. The prevalence of sleep disturbances is about 50% in dementia patients.
- Conditions
- Sleep Architecture, Sleep Disorders, Cognitive Impairment
- Trial name
- SCOAL (NCT01650454)
- Testing
- 2 night polysomnography, battery of neuropsychological tests, virtual reality test
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Stroke, Transient Ischemic Attack
DOC Utility: Screening of Depression, Obstructive Sleep Apnea and Cognitive Impairment
The primary objective of this study is to determine whether baseline DOC screening can add to clinical and demographic data to predict the occurrence of a composite negative outcome (any of: recurrent stroke, myocardial…
- Conditions
- Stroke, Transient Ischemic Attack, Depression, Obstructive Sleep Apnea
- Trial name
- NCT02363114
- Where
- Canada
- Volunteers
- 6,500 people
- Sponsor
- Dr. Richard H. Swartz
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns
This is an eight-week pilot research study designed to test whether simple changes to the bedroom environment along with brief sleep hygiene strategies, can improve sleep in older adults who live alone, have memory concerns, and…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Insomnia
- Trial name
- NCT07440498
- Testing
- Bedroom Environment Tailoring, Sleep Health Education
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Childhood Cancer, Insomnia
eHealth Insomnia Intervention for Adult Survivors of Childhood Cancer
There is evidence that survivors of childhood cancer have a high prevalence of poor sleep, including symptoms of insomnia. Insomnia is highly comorbid and has been associated with impaired cognitive performance, a range of…
- Conditions
- Childhood Cancer, Insomnia, Neurocognitive Impairment, Survivorship
- Trial name
- NCT04317742
- Testing
- Sleep Healthy Using the Internet (SHUTi) Intervention Group, Online Patient Education (PE) Control Group
- Where
- United States
- Volunteers
- 1,554 people
- Sponsor
- St. Jude Children's Research Hospital
Memory Impairment, Sleep Disorder
Improving Patient Memory for Treatment for Mild Cognitive Impairment
The main empirical question to be addressed is: What types of memory support are most potent for patients who are experiencing a mild cognitive impairment (MCI) relative to non-MCI patients?
- Trial name
- NCT05668481
- Testing
- Transdiagnostic sleep and circadian intervention (TranS-C)
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Cognitive Impairment, Dementia
Cognitive Behavioral Therapy for Insomnia for the Dementia Caregiving Dyad
Disturbed sleep is stressful to persons living with dementia (PLwD) and their caregivers. It contributes to earlier placement of the PLwD in nursing homes and increase the risk for many psychological and cognitive health issues…
- Trial name
- NCT04426838
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBTi) via Videoconference
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Emory University
Insomnia
Group Cognitive Behavioral Therapy (CBT I) Vs. Quetiapine for Residual Insomnia Impairing Recovery Among Elderly With Stable Major Affective Disorders
The purpose of this pilot study is to assess feasibility and patient accessibility in order to design an adequately powered study to compare group cognitive behavioral therapy for insomnia (CBT-I) to quetiapine in non-demented…
- Trial name
- NCT00462618
- Testing
- Quetiapine, Cogntive behavioral therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Michael E. DeBakey VA Medical Center
RETT Syndrome With Proven MECP2 Mutation
Repurposing Mirtazapine in Rett Syndrome
Rett Syndrome (RTT) is a rare neurodevelopmental disorder caused by an MECP2 gene mutation on the X chromosome, primarily affecting females.
- Trial name
- MirtaRett (NCT07430046)
- Testing
- mirtazapine
- Where
- 4 sites in Italy
- Volunteers
- 54 people
- Sponsor
- University of Trieste
Cognitive Decline, Alzheimer Disease
Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment
This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality.
- Conditions
- Cognitive Decline, Alzheimer Disease, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI)
- Trial name
- NCT06669546
- Testing
- Phase-locked auditory stimulation (PLAS)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern