Clinical trials: Sleep Insufficiency
Chronic Respiratory Failure With Hypercapnia, Chronic Obstructive Pulmonary Disease (COPD)
Study Evaluating Telemonitoring and Experimentation in Telemedicine for the Improvement of Healthcare Pathways (ETAPES Program) Compared to Standard of Care in Patients With Chronic Respiratory Failure Receiving Non-invasive Home Ventilation
The ETAPES Program, a French national Experimentation in Telemedicine for the Improvement of Healthcare Pathways, was launched in 2018 for 4 years.
- Conditions
- Chronic Respiratory Failure With Hypercapnia, Chronic Obstructive Pulmonary Disease (COPD), Obesity Hypoventilation Syndrome (OHS)
- Trial name
- e-VENT (NCT04615078)
- Testing
- ETAPES Program
- Where
- 11 sites in France
- Volunteers
- 56 people
- Sponsor
- Air Liquide Santé International
Obesity Hypoventilation Syndrome
Toffee Full Face and Toffee Nasal Mask Evaluation in Obesity Hypoventilation Syndrome (NZ)
This investigation is to evaluate the performance, comfort and ease of use of the Toffee full face and toffee nasal mask masks amongst Obesity Hypoventilation Syndrome (OHS) patients in an overnight study.
- Trial name
- NCT02486380
- Testing
- Toffee full face mask/toffee nasal mask
- Where
- New Zealand
- Volunteers
- 4 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea, Respiratory Failure
Healthcare Renunciation in Respiratory Chronic Disease and Treatment Compliance (OBSERVE)
Health care renunciation is a factor that can alter patients' health status and increase the costs of its support. To date, there is no national data on the renunciation of care.
- Trial name
- OBSERVE (NCT03591250)
- Where
- 3 sites in France
- Volunteers
- 1,083 people
- Sponsor
- University Hospital, Grenoble
Obesity Hypoventilation Syndrome
PAP Therapy in Patients With Obesity Hypoventilation Syndrome
The role of different levels of compliance and long-term effects of positive airway pressure (PAP) therapy on gas exchange, sleepiness, quality of life, depression and death rate in patients with obesity hypoventilation syndrome…
- Trial name
- NCT03449641
- Testing
- Positive airway pressure (PAP)
- Volunteers
- 252 people
- Sponsor
- University of Crete
Obesity Hypoventilation Syndrome, Obesity
The Effect of Obesity Hypoventilation Syndrome on Exercise Capacity, Peripheral Muscle Strength, and Quality of Life in Obese Individuals
Obesity Hypoventilation Syndrome(OHS) is a disease characterized by daytime hypercapnia and sleep-disordered breathing without other causes of hypoventilation in individuals with a body mass index above 30 kg/m2.
- Conditions
- Obesity Hypoventilation Syndrome, Obesity, Hypoventilation, Respiration Disorders
- Trial name
- NCT06142513
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istanbul University
Chronic Kidney Disease, Obstructive Sleep Apnea
Using Continuous Positive Airway Pressure to Reduce the Incidence of Acute Kidney Injury in Hospitalized Patients With Chronic Kidney Disease
Obstructive sleep apnea (OSA) is a common and undertreated condition in patients with chronic kidney disease (CKD). Both physiologic and empiric data suggest that renal hypoxia due to OSA is associated with worsening kidney…
- Trial name
- NCT01859260
- Testing
- CPAP/autopap
- Where
- United States
- Sponsor
- University of South Florida
Obesity Hypoventilation Syndrome (OHS)
Evaluation of Upper Extremity Functions in Obesity Hypoventilation Syndrome Patients
Obesity Hypoventilation Syndrome (OHS) is a disease characterized by daytime hypercapnia and sleep-related respiratory disturbances in individuals with a body mass index (BMI) greater than 30 kg/m², without any other condition…
- Trial name
- NCT06766110
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Istanbul University - Cerrahpasa
Obesity Hypoventilation Syndrome
Target Volume in Noninvasive Positive Pressure Ventilation
Patients with OHS are efficiently managed with long term home-based nocturnal noninvasive positive pressure ventilation (NIPPV).
- Trial name
- CIBLE (NCT01748656)
- Testing
- IVAPS, AVAPS
- Where
- France
- Volunteers
- 12 people
- Sponsor
- AGIR à Dom
Atrial Fibrillation (AF), OSA - Obstructive Sleep Apnea
Impact of Atrial Fibrillation Ablation on Sleep Parameters.
Assessment of Sleep Parameters Using Polygraphy in Patients with Paroxysmal Atrial Fibrillation Qualified for Pulmonary Vein Isolation - A Prospective Observational Study: Afib Ablation and Hypopnea Index - The "AAHI" Study…
- Conditions
- Atrial Fibrillation (AF), OSA - Obstructive Sleep Apnea, Pulmonary Vein Isolation
- Trial name
- AAHI (NCT07259200)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Primula Clinics
End-stage Renal Disease
The Effects of Cool Dialysate on the Sleep/Wake Cycle in Patients on Chronic Hemodialysis - "The Sleep Cool Study"
A major component of this study is to test a novel application for a safe, non-pharmacologic, cost-effective intervention that is already in use in clinical practice - using cool dialysate during hemodialysis to help stabilize…
- Trial name
- NCT00218790
- Testing
- Cool Dialysate
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Emory University
Obesity Hypoventilation Syndrome (OHS), Hypoventilation
Effects of Exercise Training on Exercise Capacity and Sleep Quality in Patients With Obesity Hypoventilation Syndrome
Obesity Hypoventilation Syndrome is defined as a combination of obesity (BMI ≥ 30 kg/m2) and daytime hypercapnia in arterial blood gas analysis (PaCO2 > 45 mmHg) without other pathologies that cause hypoventilation.
- Conditions
- Obesity Hypoventilation Syndrome (OHS), Hypoventilation, Obesity, Respiration Disorders
- Trial name
- NCT05398068
- Testing
- Exercises and Diet, Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Obesity Hypoventilation Syndrome
AVAPS-AE Efficacy Study
The purpose of this study is to evaluate the feasibility of using of the Average Volume Assured Pressure Support (AVAPS-AE) mode versus Continuous Positive Airway Pressure (CPAP) and bilevel pressure support ventilation (PSV)…
- Trial name
- NCT01368614
- Testing
- AVAPS-AE Mode of Therapy, Respironics OnmiLab BiPAP S mode, Respironics OmniLab Advanced CPAP mode
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Philips Respironics
Sleep Apnoea, Renal Failure
The Effect of Haemodialysis in Sleep Apnoea
Sleep disturbance is a significant issue in people undergoing dialysis. More than 80% of haemodialysis patients complain of difficulty sleeping.
- Conditions
- Sleep Apnoea, Renal Failure, End Stage Kidney Disease, Sleep Disturbance
- Trial name
- NCT02939586
- Testing
- Haemodiafiltration post-dilution model, Haemodialysis
- Where
- 2 sites in Australia
- Volunteers
- 17 people
- Sponsor
- John Hunter Hospital
Congestion, Nasal
A Pivotal Study to Assess the Effectiveness of Nasal Dilator (Breathe Right Nasal Strips)
This randomized, double-blind, parallel group, placebo-controlled study assessed subjective measures of nasal airway breathing immediately after application in the morning upon awakening after use of breathe right nasal strips…
- Trial name
- NCT03549130
- Testing
- Breathe Right Tan (small/medium) nasal strips
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- GlaxoSmithKline
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Obesity Hypoventilation Syndrome
The Obesity-hypoventilation Syndrome Study of Clinical Characteristics and Predictive Factors of Response to Treatment
Main objective: To describe clinical and functional characteristics of the obese hypoventilating patient; to study the relation between the obesity-hypoventilation syndrome (OHS) and the obstructive sleep apnea hypopnea syndrome…
- Trial name
- NCT00938977
- Testing
- CPAP, Bilevel Support Ventilation (Non-Invasive Ventilation)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome
Postoperative Complications in Patients With Obesity Hypoventilation Syndrome
Obstructive sleep apnea (OSA) and Obesity-Hypoventilation Syndrome (OHS) are common conditions in obesity, which may influence the prognosis in patients undergoing surgery.
- Conditions
- Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome, Hypercapnia, Post-Op Complication
- Trial name
- OHBE (NCT02980770)
- Where
- Turkey (Türkiye)
- Volunteers
- 999 people
- Sponsor
- Marmara University
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline
Respiratory Progression in Adults With Duchenne Muscular Dystrophy.
This is a multicenter, longitudinal observational study aimed at characterizing the natural history of respiratory progression in adults with genetically confirmed Duchenne muscular dystrophy (DMD).
- Conditions
- Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline, Restrictive Lung Disease, Respiratory Failure
- Trial name
- GUP24005 (NCT07879989)
- Where
- 13 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Giannina Gaslini
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University