Clinical trials: Sleep Obstructive Apnea
OSA - Obstructive Sleep Apnea
Effect of Weight Loss From ESG Plus Lifestyle Changes vs. Lifestyle Changes Alone in Sleep Apnea Patients
Study Overview: Obesity and Obstructive Sleep Apnea (OSA) are strongly linked. This study aims to understand whether a procedure called Endoscopic Sleeve Gastroplasty (ESG), along with lifestyle changes like healthy eating and…
- Trial name
- OSA (NCT07082608)
- Testing
- Endoscopic Sleeve Gastropathy, Lifestyle Modification alone
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Asian Institute of Gastroenterology, India
Obstructive Sleep Apnoea (OSA)
A Study Assessing Adult Patients Referred to an NHS Sleep Service With Suspected Obstructive Sleep Apnoea. This Study Aims to Compare the Sunrise Wearable Diagnostic Device Performance and Potential Inclusion in a NHS Diagnostic Pathway With Oximetry and WatchPAT Which Are Currently Used.
The goal of this clinical trial is to evaluate whether the Sunrise device (that measure small jaw movements) can improve the diagnosis and management of Obstructive Sleep Apnoea (OSA) in adults (≥ 18 years) referred to a Sleep…
- Trial name
- SOSA (NCT07269483)
- Testing
- WatchPAT 300, Oximetry, Sunrise
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Virginia Hawkins
Stroke, Acute, Obstructive Sleep Apnea
Continuous Positive Airway Pressure on Acute Stroke and Obstructive Sleep Apnea
Stroke affects 16.9 million individuals each year and is the second leading cause of death worldwide. Despite advances in pharmacologic therapy, morbidity , mortality and rates of hospitalization for stroke remain high.
- Trial name
- NCT04458779
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 71 people
- Sponsor
- Far Eastern Memorial Hospital
Epidemiology, Natural History
An 18-year Follow-up Study on OSA in a Population-based Cohort
Our research team has established a polysomnography (PSG) quantified population-based paediatric sleep cohort in 2003 for a childhood OSA prevalence study. Subjects were recruited from 13 randomly selected primary schools.
- Conditions
- Epidemiology, Natural History, Obstructive Sleep Apnea, Cardiovascular Complication
- Trial name
- NCT05077748
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Obstructive Sleep Apnea - Autonomic and Vascular Exploration
The goal of this clinical trial is to assess the effect of CPAP withdrawal on vascular and autonomic function in patients with obstructive sleep apnea.
- Trial name
- OSAVE (NCT05920083)
- Testing
- CPAP withdrawal
- Where
- Switzerland
- Volunteers
- 65 people
- Sponsor
- Raphael Heinzer
Obstructive Sleep Apnea (OSA)
A Modified Baveno Classification of Obstructive Sleep Apnoea Based on Sleepiness and Cardiovascular Scores
The goal of this observational study is to evaluate a new classification system for obstructive sleep apnoea in patients with newly diagnosed obstructive sleep apnoea and monitor for long-term objective and subjective improvement.
- Trial name
- NCT06861686
- Where
- 18 sites in Belgium, France and 9 more
- Volunteers
- 1,800 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Obstructive Sleep Apnea
Clinical Characteristics and Molecular Mechanism of Patients With Obstructive Sleep Apnea
To clarify the clinical features of patients with obstructive sleep apnea; To construct a multi-omics database of patients with obstructive sleep apnea, and compare the effects of different degrees of sleep apnea on prognosis…
- Trial name
- NCT07277608
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Obstructive Sleep Apnea
Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities
The prevalence of obstructive sleep apnea (OSA) is high in the United States and is a major health concern. This disorder is linked to numerous heart, blood vessel and nervous system abnormalities, along with increased tiredness…
- Trial name
- NCT05558501
- Testing
- Mild Intermittent Hypoxia
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea
DISE-HNS Effect Study
The purpose of this study is to assess the site, pattern and degree of upper airway collapse before and during hypoglossal nerve stimulation (HNS) treatment using clinical standard drug-induced sleep endoscopy (DISE) and using a…
- Trial name
- DISE-HNS (NCT06372847)
- Testing
- Hypoglossal nerve stimulation implant, Polysomnography, Drug-induced sleep endoscopy (DISE)
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Antwerp
Sleep, Insomnia
Actigraphy, Wearable EEG Band and Smartphone for Sleep Staging
This study aims to evaluate the viability of the combined use of wearable and portable technologies for sleep staging. The results will be compared with polysomnography, in order to achieve clinical and diagnostic validation.
- Conditions
- Sleep, Insomnia, Sleep Apnea Syndrome, Obstructive
- Trial name
- NCT04943562
- Testing
- ACT+EEG
- Where
- 2 sites in Brazil
- Volunteers
- 96 people
- Sponsor
- SleepUp Tecnologia em Saúde Ltda
Obstructive Sleep Apnea Syndrome
Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration.
- Trial name
- IRM SAOS (NCT05147649)
- Testing
- functional magnetic resonance imaging
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Hypotonia, Muscle, Obstructive Sleep Apnea
Long-term Evaluation of Nasopharyngeal Airway in Hypotonia
This research is studying the long term use of a nasal airway device (self-supporting nasopharyngeal airway; "ssNPA") in children with hypotonic upper airway obstruction to learn about its effectiveness and tolerability as a…
- Conditions
- Hypotonia, Muscle, Obstructive Sleep Apnea, Nasal Airway Obstruction
- Trial name
- NCT06614582
- Testing
- Self-Supporting Nasopharyngeal Airway (ssNPA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea
Evaluation of a Novel Auto-Adjusting Positive Airway Pressure Algorithm for the Treatment of Obstructive Sleep Apnea Clinical Study
This study aims to assess the effectiveness of an investigational algorithm in the treatment of obstructive sleep apnea.
- Trial name
- NCT06769607
- Testing
- Investigational algorithm, Control algorithm
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- ResMed
Atrial Fibrillation (AF), OSA - Obstructive Sleep Apnea
Impact of Atrial Fibrillation Ablation on Sleep Parameters.
Assessment of Sleep Parameters Using Polygraphy in Patients with Paroxysmal Atrial Fibrillation Qualified for Pulmonary Vein Isolation - A Prospective Observational Study: Afib Ablation and Hypopnea Index - The "AAHI" Study…
- Conditions
- Atrial Fibrillation (AF), OSA - Obstructive Sleep Apnea, Pulmonary Vein Isolation
- Trial name
- AAHI (NCT07259200)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Primula Clinics
Obstructive Sleep Apnea
Precision Health and Smart Telerehabilitation in OSA
This study aims to improve treatment strategies for Obstructive Sleep Apnea (OSA), a disorder characterized by recurrent upper airway collapse during sleep, resulting in reduced oxygenation, sleep fragmentation, and excessive…
- Trial name
- NCT07254026
- Testing
- Surgery, Continuous positive airway pressure, Oropharyngeal Exercise with diary
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Cheng-Kung University Hospital
Obstructive Sleep Apnea
Acetazolamide for Obstructive Sleep Apnea to Improve Heart Health
Obstructive sleep apnea (OSA) is a severe type of snoring causing people to choke in their sleep. It affects millions of Americans, causing many health problems.
- Trial name
- ACE-Of-HEARTs (NCT05616260)
- Testing
- Acetazolamide, Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Endotype-Targeted Therapy to Rescue OSA Patients Struggling With CPAP Adherence (TOP-CPAP)
More than 10% of the US population have obstructive sleep apnea (OSA). Standard of care is therapy with CPAP (continuous positive airway pressure) which virtually eliminates OSA.
- Trial name
- TOP-CPAP (NCT05951023)
- Testing
- Eszopiclone 2 mg
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Hypoxemia, Esophageal Cancer
High-flow Nasal Cannula Oxygenation in Sedated Endoscopy for High-risk Obstructive Sleep Apnea Patients
Hypoxia is the most common adverse event during propofol sedation for gastrointestinal endoscopy. The STOP-BANG questionnaire is a widely used, simple assessment tool for screening obstructive sleep apnea (OSA) risk.
- Conditions
- Hypoxemia, Esophageal Cancer, Gastric Cancer (Diagnosis), Colon Cancer
- Trial name
- NCT07155330
- Testing
- High-flow nasal cannula
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang University
OSA
Parallel Arm Trial of AD109 and Placebo With Patients With OSA (LunAIRo)
This is a Phase 3 Randomized Double-Blind Placebo-Controlled 1-year Parallel-Arm Study to Compare a Fixed Dose Combination of AD109 to Placebo in Obstructive Sleep Apnea.
- Trial name
- NCT05811247
- Testing
- AD109
- Where
- 64 sites in United States
- Volunteers
- 660 people
- Sponsor
- Apnimed
Heart Failure, Obstructive Sleep Apnea
ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
Obstructive sleep apnea (OSA), central sleep apnea (CSA) and heart failure (HF) are states of metabolic demand and sympathetic nervous system (SNS) activation.
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Central Sleep Apnea
- Trial name
- AMEND (NCT02116140)
- Testing
- [C11]Acetate and HED PET
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Heart Institute Research Corporation