Clinical trials: Sleep Obstructive Apnea
Heart Failure, Obstructive Sleep Apnea
CPAP Therapy in Patients With Heart Failure and Obstructive Sleep Apnea.
Heart failure affects approximately 5-6 million North Americans and is increasing in prevalence. Sleep-related disorders, such as obstructive sleep apnea (OSA) often coexist (11-37% incidence) with heart failure.
- Trial name
- PET-OSA (NCT00756366)
- Testing
- Positron Emission Tomography
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Obstructive Sleep Apnea, Ischaemic Heart Desease
Impact of Continuous Positive Airway Pressure (CPAP) Therapy on Outcomes in Patients Undergoing Coronary Revascularization
Investigators assume that continuous positive airway pressure (CPAP) therapy can reduce the mortality, stroke rate and secondary coronary surgery in CAD with obstructive sleep apnea (OSA) patients after percutaneous coronary…
- Trial name
- NCT02080156
- Testing
- CPAP
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Beijing Anzhen Hospital
Excessive Daytime Sleepiness, Obstructive Sleep Apnea
Pitolisant (BF2.649) in the Treatment of Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnoea Syndrome, Treated or Not by Nasal Continuous Positive Airway Pressure, But Still Complaining of Excessive Daytime Sleepiness
The first objective of this study is to demonstrate the efficacy and safety of pitolisant given at 10, 20, or 40 mg per day versus placebo during 12 weeks of the Double Blind period, to treat the Excessive Daytime Sleepiness…
- Trial name
- HAROSA IV (NCT02978651)
- Testing
- Pitolisant (BF2.649)
- Where
- 2 sites in France
- Sponsor
- Bioprojet
Upper Aerodigestive Tract Neoplasms, Obstructive Sleep Apnea-hypopnea Syndrome
Obstructive Sleep Apnea Syndrome In Patients Treated For Cancer Of The Upper Aerodigestive Tract
Prospective open-label, non-randomized, monocentric, cohort study, to assess the prevalence and severity of sleep apnea syndrome in patients treated for cancer of the upper aerodigestive tract.
- Trial name
- SAOS-K (NCT04262453)
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Sud Francilien
Obstructive Sleep Apnea, Resistant Hypertension
Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment
Hypertension affects an estimated 60-70 million Americans, predisposing them to potentially life threatening cardiovascular complications.
- Conditions
- Obstructive Sleep Apnea, Resistant Hypertension, Hyperaldosteronism
- Trial name
- NCT01897727
- Testing
- Spironolactone, BP medication uptitration
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Alabama at Birmingham
Obstructive Sleep Apnea
Oran Park Mask External Clinical Study (3) Marketing Claims Study
The goal of this prospective, randomized, open label, cross over study to assess the seal, comfort, usability, and performance of the prototype Oran Park mask system (referred to as Mask A in this study protocol) in the home…
- Trial name
- NCT06079866
- Testing
- Mask A (Oran Park Mask) then Mask B (Evora Mask), Mask B (Evora Mask) then Mask A (Oran Park Mask)
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
Dilator Muscle Activity in Health and Sleep Apnea
The role of control of peri-pharyngeal muscle tone in the pathogenesis of obstructive sleep apnea (OSA) is obvious: pharyngeal obstruction occurs only during sleep; and pharyngeal collapse occurs in almost all healthy subjects…
- Trial name
- NCT04254341
- Testing
- patients with OSA
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Obstructive Sleep Apnoea
Randomized-controlled Trial (RCT) on CPAP-withdrawal and Microvascular Function in OSA
Randomized controlled trial (therapeutic vs. placebo CPAP) including 46 patients with obstructive sleep apnea (OSA) to define the physiological effects of continuous positive airway pressure (CPAP) therapy withdrawal on…
- Trial name
- NCT01797653
- Testing
- CPAP therapy withdrawal, Continue CPAP treatment
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea (OSA)
Point of Care Ultrasound in Pregnant Women (PoCUS-OB)
Pregnant women with gestational age more than 20 weeks are at risk of developing Obstructive Sleep Apnea (OSA). OSA is a common underdiagnosed comorbid condition in pregnant women associated with adverse maternal and fetal…
- Trial name
- NCT06776237
- Testing
- PoCUS
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Sleep Apnea Syndromes, Sleep Apnea, Obstructive
How Does the Clinical and Paraclinical Efficacy of an Oral Appliance Evolved According to Propulsion: Control With Each mm of Advancement
The OAMMM study is a mono-centrer , non interventional, prospective study, carried out in CH Valence Oral Appliance is indicated for first line moderate sleep Apnea Syndrome or severe sleep Apnea Syndrome after failure of…
- Conditions
- Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Respiratory Tract Diseases
- Trial name
- OAMMM (NCT05056766)
- Testing
- questionnaires: Epworth Sleepiness Scale; Pichot fatigue questionnaire.
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier de Valence
Obstructive Sleep Apnea
Validation of the Mutuality Scale in Patients With OSA and Their Partners
Main objective of this study is to assess the psychometric characteristics of the Mutuality Scale both in patients with Obstructive Sleep Apnea Syndrome (OSAS) and in their partners-The association between the mutuality score in…
- Trial name
- VAMOS (NCT05817123)
- Testing
- Questionnaires
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Auxologico Italiano
Sleep Apnea, Obstructive
High Flow Nasal Cannula as a Treatment for Obstructive Sleep Apnea
A single center, prospective study to assess the efficacy of high flow nasal cannula (HFNC) in improving obstructive sleep apnea (OSA) parameters in patients with reduced tolerance to continuous positive airway pressure (CPAP)…
- Trial name
- NCT03017859
- Testing
- High flow nasal cannula
- Volunteers
- 30 people
- Sponsor
- Rabin Medical Center
Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Evaluation of the F&P Mask, US, 2026
This clinical investigation is designed to validate and confirm the overall performance, safety, usability, reliability, and acceptability of the F\&P PAP mask in a home environment.
- Trial name
- NCT07826429
- Testing
- F&P Licorice Mask
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
Difficult Intubation, Airway Disease
STOP-Bang Questionnaire: A Predictor of Obstructive Sleep Apnea and Difficult Mask/Intubation?
Difficult airway management remains the leading cause of anaesthesia-related morbidity and mortality. Obstructive sleep apnea syndrome (OSAS) is a warning sign of difficult airway management.
- Trial name
- NCT06247631
- Testing
- STOP BANG
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Sleep Apnea, Obstructive, Sleep Disorder
HSAT for OSA Management in Children
This clinical trial will compare the diagnostic accuracy of type II HSAT with PSG for determining OSA status following treatment with adenotonsillectomy in children
- Conditions
- Sleep Apnea, Obstructive, Sleep Disorder, Sleep Apnea Syndromes, Sleep Disturbance
- Trial name
- HOM-Kids (NCT05516524)
- Testing
- Home sleep apnea test, PSG
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Children's Hospital of Philadelphia
Scleroderma, Systemic, Sleep Apnea, Obstructive
Obstructive Sleep Apnea in Scleroderma and Pulmonary Involvement
Scleroderma is an autoimmune disease with skin manifestations and may have pulmonary involvement. Obstructive sleep apnea (OSA) may also be seen in scleroderma.
- Conditions
- Scleroderma, Systemic, Sleep Apnea, Obstructive, Pulmonary Disease
- Trial name
- OSASPI (NCT02740569)
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Marmara University
Obstructive Sleep Apnea of Adult
Comprehensive Respiratory Training Exercise Program in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a multi-factorial sleep disorder. Complete collapse or partial collapse in the airway increases the risk of developing cardiovascular and kidney-related disease in OSA patients.
- Trial name
- NCT05739617
- Testing
- Comprehensive Respiratory Training Exercise Program, Sleep hygiene education
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Cheng-Kung University Hospital
Anesthesia, General Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Postoperative Complications
- Trial name
- NCT02987985
- Testing
- Acetaminophen, gabapentin, Acetaminophen, Ketamine , Lidocaine , Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
Sleep Apnea, Obstructive
Point-of-care-Ultrasound for Sleep Apnea
Patients with obstructive sleep apnea (OSA) are at risk for respiratory dysfunction in the perioperative environment. The study is designed to evaluate if point-of-care-ultrasound (POCUS) measurements of upper airway anatomy may…
- Trial name
- NCT04443582
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Rakesh Sondekoppam Vijayashankar
Sleep Apnea, Obstructive
Predictive Factors for Prescribing a Mandibular Advancement Device for the Treatment of Obstructive Sleep Apnea
This project evaluates the morphological predictive factors for prescribing a mandibular advancement device in the therapeutic approach of Obstructive sleep apnea (OSA).
- Trial name
- NCT05677620
- Testing
- Pharyngeal Computed Tomography, Drug-Induced Sleep Endoscopy (Propofol), Mandibular Advancement Device
- Where
- Portugal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
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