Clinical trials: Sleep Symptoms
Sleep Disorder (Disorder), Anxiety Depression Disorder
The Effect of Avnace eZZe on Sleep Improvement
This study aims to examine the effectiveness of Avance eZZe drink with liposomal technology in improving sleep quality. Participants will be randomly assigned to either the placebo group, Avance eZZe drink group, and Avance eZZe…
- Trial name
- NCT07172607
- Testing
- Avance eZZe drink, Avance eZZe drink (without liposomal)
- Where
- Taiwan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Non-24-Hour Sleep-Wake Disorder
Efficacy and Safety of Tasimelteon Compared With Placebo in Totally Blind Subjects With Non-24-Hour Sleep-Wake Disorder
The purpose of this study is to evaluate the efficacy and safety of a six month double-mask treatment of tasimelteon or placebo in male and female subjects with Non-24-Hour Sleep-Wake Disorder
- Trial name
- NCT01163032
- Testing
- tasimelteon
- Where
- 28 sites in United States, Germany
- Volunteers
- 136 people
- Sponsor
- Vanda Pharmaceuticals
Smoking Cessation, Stress
Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment
This open-label study will evaluate hydroxyzine, a first-generation antihistamine, combined with varenicline, to help smokers abstain from smoking during a 12-week trial period by diminishing the nausea, stress, anxiety, and…
- Conditions
- Smoking Cessation, Stress, Sleep Disturbance, Nausea
- Trial name
- HAVE (NCT04188106)
- Testing
- Varenicline Pill, Hydroxyzine Pill
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Cognitive, Mood and Cognitive Performance
The Acute Effects of Onnit Alpha Brain on Cognition and Mood States
The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive…
- Conditions
- Cognitive, Mood and Cognitive Performance, Sleep Deprivation, Executive Function (Cognition)
- Trial name
- NCT07495592
- Testing
- Alpha Brain proprietary cognitive dietary supplement, Alpha Brain 2.0 proprietary cognitive dietary supplement
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Menopause, Hot Flashes
Randomized Evaluation of Natural Extract for Menopausal Wellness (RENEW)
This study will evaluate whether an 8-week course of a standardized herbal extract containing Shatavari and natural bio-enhancer ingredients can reduce menopausal symptoms in post-menopausal women.
- Trial name
- RENEW (NCT07834463)
- Testing
- Shatavari (Asparagus racemosus) Extract
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- India Glycols Ltd
Sleep Apnea Syndromes, Insomnia
Evaluation of the Reliability and Validity of a Diagnostic Sleep Disorders Questionnaire
The study aims to develop and test a user-friendly, accessible approach to sleep assessment which can function as an initial "triage" of targeted sleep conditions, such as insomnia, insufficient sleep syndrome, sleep apnea…
- Conditions
- Sleep Apnea Syndromes, Insomnia, Insufficient Sleep Syndrome, Circadian Rhythm Disorders
- Trial name
- NCT03468400
- Where
- 2 sites in United States, Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Dayzz Live Well Ltd.
Fatigue
Evaluate the Effectiveness and Safety of the Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health
The purpose of this study is to assess the effectiveness and safety of the Alpinia galanga formulation, Theacrine formulation, and Caffeine formulation on fatigue, mental acuity, and cognitive health among overall healthy…
- Trial name
- NCT05170113
- Testing
- Alpinia galanga formulation, Theacrine formulation, Caffeine formulation
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Depression, Anxiety
Evaluating Neuromodulation Technologies in Early Recovery
The study is an open-label comparative effectiveness clinical trial evaluating the impact of three neuromodulation treatment devices to improve the mental health and sobriety status of recovering substance abuse patients.
- Conditions
- Depression, Anxiety, Insomnia
- Trial name
- NCT01993277
- Testing
- Nexalin Brain Stimulator, Fischer Wallace Stimulator, David Delight Stimulator
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Behavioral Health of the Palm Beaches
Obstructive Sleep Apnea
Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep Apnea
The purpose of this study is to evaluate the benefits and risks of hypoglossal nerve stimulation with the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System as a potential therapeutic option for individuals with moderate…
- Trial name
- NCT01446601
- Testing
- Hypoglossal Nerve Stimulation (HGNS) System (Apnex Medical )
- Where
- 14 sites in United States, Australia
- Volunteers
- 132 people
- Sponsor
- Apnex Medical, Inc.
Central Sleep Apnea, Mixed Sleep Apnea
A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation BiPAP autoSV.
This multi-center observational study will prospectively collect data from patients who have an indication for servo ventilation therapy.
- Conditions
- Central Sleep Apnea, Mixed Sleep Apnea, Cheyne-Stokes Respiration, Complex Sleep Apnea
- Trial name
- autoSVREGDE (NCT03421704)
- Testing
- DreamStation BiPAP autoSV
- Where
- 9 sites in Germany
- Volunteers
- 129 people
- Sponsor
- Philips Respironics
Sleep Apnea, Sleep Apnea, Obstructive
A Study to Investigate the Feasibility and Respiratory Effects of Stimulating Two Functional Targets (Neural and/or Muscular) for the Treatment of Obstructive Sleep Apnea
This proof-of-concept study is to collect acute and short-term sub-acute (if applicable) changes in respiratory parameters following the percutaneous placement of electrode arrays.
- Conditions
- Sleep Apnea, Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Sleep Disorder
- Trial name
- NCT06627127
- Testing
- Target stimulation (HGN, AC, GG, Strap muscles)
- Where
- 4 sites in Australia
- Volunteers
- 35 people
- Sponsor
- Invicta Medical Inc.
Obstructive Sleep Apnea (OSA), Atrial Fibrillation (Paroxysmal)
Rhythm Express Wearable System vs. Simultaneous Polysomnography for the Diagnosis of Obstructive Sleep Apnea in Adults With Suspected or Observed Atrial Fibrillation
The goal of this observational study is to confirm the accuracy of the sleep algorithm (software) used in the Rhythm Express Wearable System to detect sleep apnea severity.
- Conditions
- Obstructive Sleep Apnea (OSA), Atrial Fibrillation (Paroxysmal), Palpitations
- Trial name
- NCT06907888
- Testing
- Rhythm Express Wearable System
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- VivaQuant
Menopause, Sleep Disturbance
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
A randomized, double-blind, placebo-controlled, direct-to-consumer trial assessing the impact of health and wellness products on hormonal health and associated health outcomes in women with menopausal health issues
- Conditions
- Menopause, Sleep Disturbance, Anxiety, Depression
- Trial name
- NCT06749288
- Testing
- Radicle Revive Active Study Product 4.1 Usage
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Radicle Science
OSA, Overweight or Obesity
A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight
Study GZRA is a master protocol that will support 2 independent studies, GZ01 and GZ02. Participants will be assigned to the appropriate study prior to randomization.
- Trial name
- ATTAIN-OSA (NCT06649045)
- Testing
- Orforglipron
- Where
- 66 sites in United States, Argentina and 7 more
- Volunteers
- 712 people
- Sponsor
- Eli Lilly and Company
Sleep Disorder
Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ABT-652 in Subjects With Excessive Daytime Sleepiness
The main purpose of this study is to evaluate the safety and tolerability of the drug ABT-652 given once daily to people with excessive daytime sleepiness.
- Trial name
- NCT01124851
- Testing
- ABT-652
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Abbott
Heartburn
A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes
This decentralized, randomized, double-blind, placebo-controlled, two-period crossover study will evaluate whether PepZinGI® (zinc-L-carnosine) reduces food-triggered heartburn compared with placebo.
- Trial name
- NCT07379645
- Testing
- PepZinGI
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NutriScience Innovations, LLC
Sleep Deprivation
Impact of THN102 on Attention, Wakefulness and Cognitive Performance During Total Sleep Deprivation
Study Objectives: THN102 is a new combination between modafinil and flecainide low-dose, a documented glial connexin inhibitor. Efficacy of THN102 was compared to modafinil and to placebo on parameters impaired by total sleep…
- Trial name
- NCT03182413
- Testing
- Modafinil, THN102
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Theranexus
Sleep Deprivation
Pharmacodynamic Profile of SPD489 in Healthy Adult Males Undergoing a Nocturnal Period of Acute Sleep Loss
This is a double-blind, single center, parallel group, placebo and active comparator, controlled study to characterize the wake promoting effects of single doses of SPD489 in healthy adult male undergoing acute sleep deprivation.
- Trial name
- NCT01096680
- Testing
- SPD489 20 mg, SPD489 50 mg, SPD489 70 mg
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Shire
COPD (Chronic Obstructive Pulmonary Disease), Obesity Hypoventilation Syndrome (OHS)
The Effect of Mask Design on Ventilation Parameters in COPD and OHS Patients on Long-term Home Non-invasive Ventilation. An Experimental Study.
Chronic obstructive pulmonary disease (COPD) and obesity hypoventilation syndrome (OHS) are respiratory conditions that disrupt normal breathing.
- Trial name
- NCT06972589
- Testing
- Investigational Mask, Conventional mask
- Where
- New Zealand
- Volunteers
- 20 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep, Sleep Disturbance
Radicle Rest 2: A Study of Health and Wellness Products on Sleep and Health Outcomes
A randomized, blinded, placebo-controlled direct-to-consumer study assessing the impact of health and wellness products on sleep and other health outcomes.
- Conditions
- Sleep, Sleep Disturbance, Sleep Disorder
- Trial name
- NCT05657808
- Testing
- Rest Study Active Product 1.1 Usage, Rest Study Active Product 1.2 Usage, Rest Study Active Product 2.1 Usage
- Where
- United States
- Volunteers
- 4,152 people, healthy volunteers welcome
- Sponsor
- Radicle Science