Clinical trials: Sleep-Disordered Breathing
Sleep Disordered Breathing, Obstructive Sleep Apnea
Adenotonsillectomy for Obstructive Sleep-Disordered Breathing in Childhood:The Chania Community Oximetry-Based Study
Obstructive sleep-disordered breathing (SDB) in childhood is a disorder of breathing during sleep characterized by intermittent upper airway obstruction.
- Conditions
- Sleep Disordered Breathing, Obstructive Sleep Apnea, Snoring, Obstructive Sleep Disordered Breathing
- Trial name
- NCT01918007
- Testing
- Adenotonsillectomy (AT)
- Where
- 2 sites in Greece
- Volunteers
- 186 people
- Sponsor
- Chania General Hospital "St. George"
COPD, OSA
PSG Versus Oxim-capnography to Setup Home NIV
The study aims to compare 2 different strategies used to setup non-invasive ventilation in patients with OCPD-OSA overlap.
- Trial name
- NCT02444806
- Testing
- Full polysomnography, Oximetry-capnography
- Volunteers
- 14 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Central Sleep Apnea, Complex Sleep Apnea
Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation
Phase 1: The European ASV Registry (short name) will investigate the use of Adaptive Servo-Ventilation in non-heart failure conditions.
- Conditions
- Central Sleep Apnea, Complex Sleep Apnea, Obstructive Sleep Apnea, Mixed Sleep Apnea
- Trial name
- READ-ASV (NCT03032029)
- Testing
- Adaptive Servo-Ventilation
- Where
- 29 sites in Denmark, France and 4 more
- Volunteers
- 847 people
- Sponsor
- ResMed
Obstructive Sleep Apnea
Face of Sleepiness
The purpose of this pilot study is to find out whether successful treatment of obstructive sleep apnea makes people look less sleepy, for example by reducing swelling or dark circles under the eyes.
- Trial name
- Face (NCT01060436)
- Testing
- CPAP or BiPAP machines
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode, Breathing-Related Sleep Disorder
nuMoM2b Heart Health Study
This study is looking at the relationship between experiences during pregnancy and cardiovascular health 2 to 3½ years later. The investigators are recruiting women from the approximately 10,000 women who were enrolled and…
- Trial name
- nuMoM2b-HHS (NCT02231398)
- Where
- 15 sites in United States
- Volunteers
- 4,509 people
- Sponsor
- RTI International
Obstructive Apnea, Sleep Apnea Syndrome, Obstructive
Pilot Study of Negative Pressure Neck Therapy (NPNT)
Obstructive sleep apnea (OSA) is a serious, chronic sleep-related breathing disease in which the upper airway repeatedly collapses during sleep, leading to intermittent oxygen deprivation.
- Conditions
- Obstructive Apnea, Sleep Apnea Syndrome, Obstructive, Sleep Disorder (Disorder)
- Trial name
- NCT07301567
- Testing
- Negative Pressure Neck Therapy (NPNT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Sleep Disordered Breathing (SDB), Sleep Apnea
Neurostimulation for Sleep Disordered Breathing
This is a first in human study to determine if the Lunair Alpha System is safe and effective for treating moderate to severe sleep disordered breathing.
- Trial name
- ECLIPSE 1 (NCT06883617)
- Testing
- Neuro stimulator Implant
- Where
- Paraguay
- Volunteers
- 45 people
- Sponsor
- Lunair Medical
Sleep Apnea
A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing
This is a single center pilot study evaluating the immediate effects of low-dose acetazolamide on respiratory control in subjects with treatment emergent sleep disordered breathing.
- Trial name
- NCT02670096
- Testing
- Acetazolamide
- Where
- United States
- Sponsor
- NYU Langone Health
Sleep-Disordered Breathing, Sleep Architecture
Ring-type Pulse Oximeter for Evaluation for Sleep Assessment Study
Recently, various electronic lifestyle activity monitoring devices (ELAM) are increasingly commercially available. However, the quality and reliability of the data from ELAM are unclear, compared with polysomnography (PSG), which…
- Trial name
- ROSA (NCT06221124)
- Testing
- Belun Ring Pulse Oximeter
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Belun Technology Company Limited
Healthy, Healthy Adult
Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level and re-ascent from sea level to 2850m on heart rate variability and other hemodynamic parameters in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801846
- Testing
- Descent and re-ascent (2850m, sea level)
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Sleep Apnea, End Stage Renal Disease
Impact of Different Dialysis on Sleep Apnea in Patients With Renal Failure
The purpose of this study is to determine whether hemodiafiltration, a new form of hemodialysis can improve sleep apnea in patients with end stage kidney disease.
- Trial name
- NCT00380848
- Testing
- Hemodiafiltration
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Central Sleep Apnea, Mixed Sleep Apnea
A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation BiPAP autoSV.
This multi-center observational study will prospectively collect data from patients who have an indication for servo ventilation therapy.
- Conditions
- Central Sleep Apnea, Mixed Sleep Apnea, Cheyne-Stokes Respiration, Complex Sleep Apnea
- Trial name
- autoSVREGDE (NCT03421704)
- Testing
- DreamStation BiPAP autoSV
- Where
- 9 sites in Germany
- Volunteers
- 129 people
- Sponsor
- Philips Respironics
Asthma, Sleep Disordered Breathing
Personalized Asthma Care Team
"Individualized health care" refers to the development of strategies for disease management and health promotion that are informed by specific data on genetics and physiological processes that uniquely determine each person's…
- Conditions
- Asthma, Sleep Disordered Breathing, Obesity
- Trial name
- PACT (NCT01423461)
- Volunteers
- 201 people
- Sponsor
- Brigham and Women's Hospital
Sleep Disordered Breathing, Obstructive Sleep Apnea
The Evaluation of a Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea (OSA)
This investigation is designed to evaluate the performance as well as the patients overall acceptance of the mask.
- Trial name
- NCT02894242
- Testing
- F&P Deimos Nasal Pillows Mask
- Where
- 2 sites in New Zealand
- Volunteers
- 22 people
- Sponsor
- Fisher and Paykel Healthcare
Breathing-Related Sleep Disorder
A Pilot Study to Assess the Effects of a Novel Application of Averaged Volume Assured Pressure Support Ventilation (AVAPS-AE) Therapy on Re-hospitalization in Patients With Sleep-Disordered Breathing With Co-morbid COPD
This is a multicenter, randomized, parallel-group, open label study of the efficacy of AVAPS-AE to prevent re-hospitalization in hospitalized patients with comorbid Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- STOP-BBACK (NCT02446769)
- Testing
- AVAPS-AE Non-invasive ventilation therapy
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Philips Respironics
Sleep Disordered Breathing (SDB)
Comprehensive Care of Sleep Disordered Breathing
The Comprehensive Care of Sleep Disordered Breathing study (Care-SDB) is a prospective, multi-center, registry-based cohort study designed to investigate the integrated management of sleep-disordered breathing (SDB).
- Trial name
- Care-SDB (NCT07339371)
- Testing
- Clinical Management for SDB
- Where
- China
- Volunteers
- 11,100 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Sleep Apnea, Pregnancy
Pregnancy, Sleep Disordered Breathing and Peripartum Complications
Sleep disordered breathing (SDB) during pregnancy is a modifiable risk factor for poor maternal and fetal outcomes. The investigators propose a prospective observational study to assess the utility of continuous positive airway…
- Trial name
- NCT02651649
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Obstructive Sleep Apnea, Obesity
Obesity and Obstructive Sleep Apnea (OSA) in Children
The goal of this research is to study the prevalence of sleep disordered breathing and associated morbidity in obese children and to examine the role of diet and physical activity in the treatment of sleep-disordered breathing in…
- Trial name
- NCT01135147
- Testing
- Diet, Surgery
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Heart Failure With Preserved Ejection Fraction, Sleep Disordered Breathing
Heart Function in Patients Assessed for Sleep Apnoea
This study aims to determine the prevalence and prognosis of heart failure with preserved ejection function (HFpEF) among patients being assessed for sleep disordered breathing (SDB).
- Conditions
- Heart Failure With Preserved Ejection Fraction, Sleep Disordered Breathing, Heart Failure With Normal Ejection Fraction, Obstructive Sleep Apnea
- Trial name
- NCT03226652
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- Imperial College London
Obstructive Sleep Apnea
Accelerated Aging in Middle-Aged Men With Sleep-disordered Breathing.
Obstructive Sleep Apnea Syndrome (OSAS) regardless of any other associated risk factor can lead to accelerated aging. The study of aging-related Obstructive Sleep Apnea (OSA) is difficult because of associated risk factors…
- Trial name
- SAOS (NCT02876653)
- Testing
- Polysomnography , blood collection, bone densitometry and Functional respiratory explorations
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris