Clinical trials: Sleep-Wake Disorders
Sleep Disturbance, Craving
The Efficacy of Suvorexant in Treatment of Patients With Substance Use Disorder and Insomnia: A Pilot Open Trial
Insomnia is an extremely common and poorly treated problem in patients with substance use disorders (SUD)s undergoing rehabilitation treatment in a residential facility.
- Conditions
- Sleep Disturbance, Craving, Cortisol; Hypersecretion
- Trial name
- Suvsubuse (NCT03412591)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Milton S. Hershey Medical Center
Fatigue
A Randomized Controlled Trial of Mandatory Naps for Physicians in Training
This study will consist of a randomized controlled trial in which the investigators test the feasibility and effectiveness of mandatory nap programs for physicians in training.
- Trial name
- NCT00874510
- Testing
- Mandatory Naps
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- VA Office of Research and Development
Sleep Initiation and Maintenance Disorders, Depression
Improving Sleep and Psychological Functioning in People With Depression and Insomnia
This study will evaluate the safety and effectiveness of treatment with both a sleeping pill and antidepressant medication in improving sleep and psychological functioning in people with depression and insomnia.
- Trial name
- NCT00247624
- Testing
- Eszopiclone, Fluoxetine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Sleep, Insomnia
Treatment of Insomnia and Glucose Metabolism
Available data suggest that obtaining adequate sleep is associated with a better ability of the body to use carbohydrates as a source of energy and a lower risk of developing diabetes.
- Conditions
- Sleep, Insomnia, Insulin Resistance
- Trial name
- NCT00724282
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Narcolepsy
A Study of the Safety and Effectiveness of ADX-N05 in the Treatment of Excessive Daytime Sleepiness
This is a study to evaluate the safety and effectiveness of ADX-N05 compared to placebo in the treatment of excessive daytime sleepiness in adults with narcolepsy.
- Trial name
- NCT01485770
- Testing
- ADX-N05
- Where
- 10 sites in United States
- Volunteers
- 33 people
- Sponsor
- Jazz Pharmaceuticals
Interstitial Lung Disease, Obstructive Sleep Apnea
Assessment of Continuous Positive Airway Pressure Therapy in OSA and ILD
The purpose of this study is to evaluate whether biomarkers of lung epithelial and endothelial injury are associated with obstructive sleep apnea (OSA) and interstitial lung disease (ILD).
- Trial name
- NCT03901534
- Testing
- Continuous positive airway pressure (CPAP) therapy, Nox A1 Recorder
- Where
- 2 sites in United States
- Volunteers
- 2,021 people
- Sponsor
- Columbia University
Sleep Initiation and Maintenance Disorders
Light Treatment for Sleep/Wake Disturbances in Alzheimer's Disease
The aim of this study is to demonstrate the efficacy of timed exposure to bright light for the treatment of disturbed nighttime sleep and daytime wake in community-dwelling dementia patients and their caregivers, and to determine…
- Trial name
- NCT00946530
- Testing
- Bright light, Control
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Stanford University
Restless Legs Syndrome (RLS)
Randomized, Placebo-controlled Trial of Ferric Carboxymaltose in RLS Patients With Iron-deficiency Anemia
Treatment Phase I and II Primary Objective: To evaluate the efficacy and safety of FCM (750 mg dose x 2) for treatment of Restless Legs Syndrome (RLS) in patients with iron-deficiency anemia (IDA).
- Trial name
- NCT02826681
- Testing
- Injectafer® (Ferric Carboxymaltose - FCM)
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- American Regent, Inc.
Advanced Cancers
The Use of Light Therapy for Managing Sleep Disturbances in Patients With Advanced Cancer
The goal of this research study is to learn if a type of light therapy can be used to help patients with advanced cancer who are having difficulty sleeping to sleep better.
- Trial name
- NCT01193530
- Testing
- Bright Light Therapy, Dim Red Light Therapy, Questionnaires
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Sleep Apnea, Obstructive
Telecommunications System in Sleep Apnea
This study is investigating the effects of a telecommunications system designed to improve patient adherence with prescribed positive airway pressure (CPAP).
- Trial name
- NCT00232544
- Testing
- Telecommunications system, TLC-Control
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Insomnia
Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon
Hypothesis I: Patients in the SSRI + ramelteon treatment group will achieve remission (defined as an IDS-C30 score of 11 or less) more quickly than those in the SSRI + placebo group.
- Trial name
- TAKEDA (NCT00642694)
- Testing
- Escitalopram, Ramelteon
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Texas Southwestern Medical Center
Sleep Apnea, Obstructive, Patient Compliance
Tailored Intervention to Promote Positive Airway Pressure Adherence
The purpose of this study is to examine the feasibility of a tailored (i.e., individualized) intervention to promote adherence to continuous positive airway pressure therapy (CPAP) in adults with newly-diagnosed, CPAP treated…
- Trial name
- SCIP-PA (NCT01454830)
- Testing
- Tailored, Usual care
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Milton S. Hershey Medical Center
Insomnia Disorder
Efficacy and Safety of ACT-541468 in Adult Subjects With Insomnia Disorder
This study evaluates the dose response of ACT-541468 on the change of WASO from baseline to Days 1 and 2, assessed by PSG.
- Trial name
- NCT02839200
- Testing
- ACT-541468 5 mg, ACT-541468 10 mg, ACT-541468 25 mg
- Where
- 35 sites in United States, Germany and 4 more
- Volunteers
- 360 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Prostatic Neoplasms
The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females
Background: Insomnia is associated with difficulty sleeping. The drug zolpidem is widely prescribed for insomnia. Women have reported worse effects from the drug than men.
- Trial name
- NCT03436745
- Testing
- Zolpidem, ECG
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Obstructive Sleep Apnea
Oxygen Saturation Patterns in Post-Op Patients at Risk for Obstructive Sleep Apnea
This study will include patients who have major surgery and are at risk for or have been diagnosed with sleep apnea. The patients will be monitored the night after surgery for repeating episodes of reduced breathing and oxygen…
- Trial name
- NCT01078207
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Medtronic - MITG
Obstructive Sleep Apnea Syndrome
Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients
To study the effect of Xyrem (9 g), Xyrem (9 g) plus modafinil 200 mg administered the morning prior to Xyrem, positive control (zolpidem 10 mg), and placebo on the frequency and outcome of events of sleep-disordered breathing in…
- Trial name
- NCT00086281
- Testing
- Xyrem (X), Zolpidem (Z), Modafinil (M)
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Jazz Pharmaceuticals
Circadian Rhythm Sleep Disorders
Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers
The purpose of this study is to assess the safety and efficacy of VEC-162 compared to matching placebo on circadian phase shift and sleep parameters.
- Trial name
- NCT00490945
- Testing
- VEC-162
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Obstructive Sleep Apnea Syndrome
The Use of Heliox in Obstructive Sleep Apnea Syndrome
The goals of the project is to evaluate the effects of Heliox therapy on obstructive sleep apnea syndrome (OSAS).
- Trial name
- HOSA (NCT02135900)
- Testing
- Heliox
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Northwell Health
Obstructive Sleep Apnea
Pediatric Nasal Mask Usability Study
The purpose of the study is to demonstrate the effectiveness of a pediatric mask in treating obstructive sleep apnea (OSA) in a pediatric population.
- Trial name
- NCT01154322
- Testing
- Pixi pediatric mask
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- ResMed
Delirium, Sleep Fragmentation
Direct Noise Reduction in the Intensive Care Units (ICU) Using Earplugs and Noise Canceling Headphones
This study seeks to examine the effects of overnight noise reduction in critically ill patients who are receiving mechanical ventilation.
- Trial name
- NCT01343095
- Testing
- Foam Earplugs, Noise Canceling Headphones
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wake Forest University