Clinical trials: Sleeping Efficacy
Insomnia Chronic
Efficacy of Sleeping Without Pills (SWOP), an Online Drug Tapering Program
The aims of the study are to determine whether an online drug tapering program can lead to successful drug tapering in hypnotic dependent insomnia and whether such tapering is associated with improved daytime functioning and…
- Trial name
- NCT03194802
- Testing
- Sleeping Without Pills Program, Self-monitoring
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
OSA, Apnea+Hypopnea
Impact of Breathing Route on CPAP Effectiveness to Treat Obstructive Sleep Apnea
To determine the impact of the CPAP route (oronasal vs oral) in patients diagnosed with moderate-severe OSA using CPAP with oronasal mask on CPAP level, residual AHI, and peak flow.
- Trial name
- NCT05272761
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Restless Leg Syndrome
Restless Legs Syndrome in Hemodialysis Patients
Restless legs syndrome (RLS) is defined as the spontaneous movement of the limbs (mainly legs) associated with unpleasant - painful sensation which is relieved by moving the affected limb.
- Trial name
- NCT03337529
- Testing
- Vitamin C
- Where
- Lebanon
- Volunteers
- 19 people
- Sponsor
- Makassed General Hospital
Breast Cancer, Sleep Hygiene
Feasibility and Effectiveness of a Sleep Hygiene Education Program for Sleep Issues in Breast Cancer Survivors
The proposed research will assess the feasibility and preliminary effectiveness of a Sleep Hygiene Program for Breast Cancer Survivors.
- Trial name
- NCT04232319
- Testing
- Sleep Hygiene Training
- Where
- United States
- Sponsor
- University of Toledo Health Science Campus
Primary Insomnia
Comparison of Efficacy of Behavioral Approaches for Treatment of Insomnia
This study compares the efficacy of four different types (Cognitive Behavior Therapy for Insomnia (CBT-I); Focus of Attention (FOA); Combined CBT-I and FOA; and Sleep Hygiene (control group) for the treatment of insomnia.
- Trial name
- CEBATI (NCT03461666)
- Testing
- Cognitive Behavior Therapy-Insomnia, Focus of Attention, Combined-CBT-I and FOA Group
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Pacific Institute of Medical Sciences
Neoplasms, Cancer Survivorship
Effectiveness of a Guided, Web-based, Stepped-care-approach to Cognitive Behavioral Therapy for Insomnia in Cancer Survivors
The goal of this multicenter randomized clinical trial is to develop and evaluate a web-based stepped-care approach to Cognitive Behavioral Therapy for Insomnia (CBT-I), specifically tailored to adult cancer survivors…
- Conditions
- Neoplasms, Cancer Survivorship, Insomnia
- Trial name
- eNightfall (NCT07876661)
- Testing
- Stepped-care Cognitive Behavioral Therapy for Insomnia, Standard web-based Cognitive Behavioral Therapy for Insomnia, Control arm - Care as usual with sleep hygiene leaflet
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Vrije Universiteit Brussel
Stress, Burnout
An Efficacy Trial of the MindFi App for Stress, Well-being, and Sleep Quality in Working Adults
90% of Asian workers report high levels of stress in an "always-on" culture. Stress and burnout are risk factors that account for 10-20% of health expenditure and threaten work longevity in the world's fastest growing economies.
- Trial name
- NCT05085132
- Testing
- MindFi app: Standard content, Mindfi app: Standard content without practice
- Where
- Singapore
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome
Randomized Controlled Trial Between Auto-titration and Manual Titration of Non-invasive Ventilation in Obesity Hypoventilation Syndrome
Primary Objectives: To evaluate the effectiveness in the obesity hypoventilation syndrome (OHS) treatment with non-invasive ventilation (NIV) set manually by polysomnography compared to the same treatment with a respirator with…
- Trial name
- TITRATION (NCT04327336)
- Testing
- Manual Non invasive ventilation titration, Automatic Non invasive ventilation titration
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Restless Legs Syndrome
Assess Efficacy and Safety of the Dopamine Agonist Pramipexole Versus Levodopa / Benserazide (Madopar® DR) in Patients With Restless Legs Syndrome
The primary objective of this study is to determine that pramipexole (Sifrol) 0.25 mg to 0.75 mg daily is not inferior to levodopa 100 mg to 300 mg (in combination with benserazide 25mg to 75mg = Madopar DR) daily in the…
- Trial name
- NCT00144209
- Testing
- pramipexole, levodopa in combination with benserazide
- Where
- 6 sites in Switzerland
- Volunteers
- 58 people
- Sponsor
- Boehringer Ingelheim
Lung Diseases, Sleep Apnea Syndromes
Apnea Positive Pressure Long-Term Efficacy Study
The purpose of this study is to determine the effectiveness of nasal continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea syndrome (OSAS).
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Sleep
- Trial name
- APPLES (NCT00051363)
- Testing
- Active CPAP
- Where
- 5 sites in United States
- Volunteers
- 1,105 people
- Sponsor
- Stanford University
Behavioural Insomnia of Childhood
A Longitudinal Study of Parental Sleep Intervention for Behavioral Insomnia in Early Childhood
The global incidence of mental illness among children and adolescents is rising, drawing increasing attention to early risk factors and preventive strategies.
- Trial name
- SuSleep (NCT07420504)
- Testing
- Parental sleep enhancement intervention
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Soochow University
Ischemic Stroke
Reversal of the Neurological Deficit in Acute Stroke With the Signal of Efficacy Trial of Auto BPAP to Limit Damage From Suspected Sleep Apnea
Although the negative impact of sleep apnea on the clinical course of acute ischemic stroke (AIS) is well known, data regarding non-invasive ventilation in acute patients are scarce.
- Trial name
- Reverse-STEAL (NCT01812993)
- Testing
- Non-invasive ventilatory treatment with auto-BPAP
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 60 people
- Sponsor
- Technische Universität Dresden
Obstructive Sleep Apnea of Adult
BiLAteral Hypoglossal Nerve Stimulation for Treatment of Obstructive Sleep Apnoea (BLAST OSA)
The study is designed as a prospective, open-label, multicentre, non-randomized, single arm treatment study to assess the safety, performance and initial efficacy trends of the GenioTM System in patients with Obstructive Sleep…
- Trial name
- NCT03048604
- Testing
- Genio(TM) bilateral hypoglossal nerve stimulation system
- Where
- 3 sites in Australia, France and 1 more
- Volunteers
- 27 people
- Sponsor
- Nyxoah S.A.
Obstructive Sleep Apnea
Registry Study on Prescription, Patient Pathways, Therapy Efficacy and Usage of Mandibular Advancement Devices in Obstructive Sleep Apnea - PATT-OSA Registry
During sleep, the muscle tonus in the oropharyngeal space is lost, the tongue might fall back andthe volume of the pharynx decreases. Air cannot pass through as it would in the awake state and thus airflow limitations occur.
- Trial name
- PATT-OSA (NCT03924817)
- Where
- 4 sites in Germany
- Volunteers
- 500 people
- Sponsor
- ResMed
Nocturnal Bruxism
The Use of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle to Treat Sleep Bruxism
Botulinum toxin (BOTOX®) injections into the masseter muscle are an effective treatment for nocturnal bruxism, with several trials using various dosages of botulinum toxin for this purpose.
- Trial name
- NCT05620316
- Testing
- BOTOX® Injection, Prick skin
- Where
- Syria
- Volunteers
- 22 people
- Sponsor
- Damascus University
Mild Cognitive Impairment (MCI)
Effect of Intranasal Negative Pressure Therapy on Cognitive Function in Patients With Mild Cognitive Impairment and Obstructive Sleep Apnea
This study is a randomized controlled trial with two phases: pre-trial and formal trial. The pre-trial will include 5 participants to observe the 4-week adherence (≥4 hours/night) and safety (adverse event rate) of the iNAP…
- Trial name
- NCT07353359
- Testing
- Intranasal Negative Pressure
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xuanwu Hospital, Beijing
Insomnia, Comorbidities and Coexisting Conditions
A Mixed-method Pilot Investigation of Paradoxical Intention for Insomnia.
The investigators aim to test the preliminary efficacy as well as the acceptability and feasibility of paradoxical intention, which is a psychotherapeutic technique, for improving insomnia symptoms in adults.
- Trial name
- NCT06259682
- Testing
- Paradoxical Intention
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Örebro University, Sweden
Depression
The Efficacy of a Depression Intervention for Adolescents With Depression and Sleep Disturbances
The focus of this study is on identifying how Interpersonal Psychotherapy for Adolescents (IPT-A) with depression works to change sleep and related biological markers found in saliva, namely cortisol and pro-inflammatory cytokine…
- Trial name
- NCT02429674
- Testing
- TranS-C and IPT-A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- New York State Psychiatric Institute
Insomnia
Efficacy and Safety of Two Doses of Hipnos in the Treatment of Adults With Insomnia
The purpose of this study is to evaluate the efficacy and safety of three doses of Hipnos medication in adults with insomnia.
- Trial name
- NCT03814135
- Testing
- Hipnos 3, Hipnos 5
- Sponsor
- EMS
Diabetes, Prediabetic
Sleep Effectiveness and Insulin and Glucose Homeostasis
The purpose of this study is to examine the influence of sleep effectiveness on glucose and insulin metabolism in health and disease (prediabetes and type two diabetes).
- Conditions
- Diabetes, Prediabetic, Prediabetes, Glucose Intolerance
- Trial name
- NCT01887691
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center