Clinical trials: Small Airway Disease
Obstructive Sleep Apnea
Validation and Reproducibility of the Six-minute Step Test in Individuals With Obstructive Sleep Apnea Treated With CPAP
Introduction: The Obstructive Sleep Apnea (OSA) is characterized by obstructed superior airway during sleeping period promoting intermittent hypoxia-reoxygenation events.
- Trial name
- NCT03334331
- Testing
- Six-minute step test, Six-minute walk test
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Universidade Federal de Pernambuco
Pulmonary Disease, Chronic Obstructive, Asthma
Management and Healthcare Utilization of Patients With Chronic Airway Disease During the COVID-19 Epidemic
During the COVID-19 epidemic, the medical treatment, disease status, and medication status of patients with chronic airway disease have not been studied.
- Trial name
- NCT04948216
- Testing
- No intervention
- Where
- China
- Volunteers
- 153 people
- Sponsor
- Peking University Third Hospital
Smoking, COPD
Integrative-omics of the Disordered COPD Small Airway Epithelium
We aim to use an integrated network systems approach to analyze certain existing small airway epithelium (SAE) omic data sets at the genetic, epigenetic (methylation), gene expression, microRNA and metabolomic levels, to develop…
- Trial name
- NCT02183818
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO)
The purpose of this study is to research the differences of small airways function between subjects with diagnosis of chronic obstructive pulmonary disease(COPD) and asthma-COPD overlap(ACO).The assessment of quality of life is…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome, Small Airway Disease, Quality of Life
- Trial name
- NCT03563001
- Testing
- Budesonide(160ug) and Formoterol(4.5ug) bid
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
COPD Exacerbation, COPD
Impulse Oscillometry in COPD Exacerbation
This study aimed to evaluate small airway function during ECOPD and recovery periods using IOS. In this prospective single-center study, patients with ECOPD underwent evaluation of their pulmonary functions using IOS and…
- Trial name
- NCT07185581
- Testing
- Impulse Oscillometry
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Deniz Bilici
Asthma, Airway Hyperresponsiveness
Small Airways Disease in Asymptomatic and Symptomatic Subjects With Airway Hyperresponsiveness (AHR)
The purpose of this study is to study differences in small airways (<2mm) parameters in asthma patients, subjects with asymptomatic airway hyperresponsiveness and healthy controls.
- Trial name
- ABHR (NCT01549483)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Asthma
Development of Small Airway Disease Questionnaire
The aim of this study is to develop a patient reported outcome tool specific to small airways disease, which assesses symptoms and signs of small airways disease and may help in addition to FEF50% to discriminate between…
- Trial name
- SADQ (NCT01360294)
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- University Medical Center Groningen
Cystic Fibrosis in Children
Detection of Unsuspected Small Airways Obstruction in Cystic Fibrosis
Goal is to physiologically detect unsuspected small airways obstruction in children and adults with treated heterozygous and homozygous cystic fibrosis.
- Trial name
- NCT03839992
- Testing
- spirometry
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Gelb, Arthur F., M.D.
Croup, Bronchiolitis
A Study Evaluating the Use of ResAppDx v2.0 as an Aid to Diagnose Respiratory Disease in Paediatric Patients in an Emergency Department
Aim of study is to demonstrate that the ResAppDx v2.0 algorithms provide an accurate diagnosis of paediatric respiratory disease in the study's clinical setting compared to a Clinical Adjudication Committee's (CAC) diagnosis; and…
- Conditions
- Croup, Bronchiolitis, Asthma in Children, Reactive Airway Disease
- Trial name
- NCT06156436
- Testing
- ResAppDx v.20
- Where
- 5 sites in United Kingdom
- Volunteers
- 75 people
- Sponsor
- ResApp Health Limited
Asthma
Efficacy of Ciclesonide on Small Airways in Patients With Stable Asthma (18 to 60 y) (BY9010/M1-131)
The aim of this study is to evaluate the involvement of small airways in asthma, as determined by bronchial challenges, CT-scanning, and cellular markers of inflammation. Ciclesonide will be inhaled at one dose level once daily.
- Trial name
- NCT00163345
- Testing
- Ciclesonide
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Nasal Septum Perforation
Nasal Septal Flap for Donor Site Reconstruction
The purpose of this study is to demonstrate the utility of porcine small intestinal submucosa (SIS) as a graft material that may aid in the natural healing process of freshly exposed bone and cartilage in the nasal cavity.
- Trial name
- NCT03159624
- Testing
- Biodesign™ SIS graft, Doyle silastic sheet
- Volunteers
- 47 people
- Sponsor
- University of Alabama at Birmingham
COVID-19
Small Airway Disease And Bronchial Hyperreactivity In Patients With Post Acute Covid-19 Syndrome
The aim of this work is to estimate the frequency of small airway disease and/or the bronchial hyperreactivity in follow up of postacute covid survivors.
- Trial name
- NCT06374420
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Asthma
Small Airway Function of Fluticasone/Formoterol (Flutiform®) and Fluticasone/Salmeterol
The purpose of this study is to demonstrate superiority of Fluticasone/Formoterol (Flutiform®) to Fluticasone/salmeterol based on the small airway function by assessing the Impulse Oscillometic System (IOS) in uncontrolled asthma…
- Trial name
- RECONFFIRM (NCT02491970)
- Testing
- Fluticasone/Formoterol, Fluticasone/Salmeterol
- Volunteers
- 15 people
- Sponsor
- Mundipharma Korea Ltd
COPD
Diagnostic and Therapeutic Approaches to Hyperinflation and Small Airway Disease in COPD
Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. Hyperinflation and affection of the small airways are two components that are not represented in current…
- Trial name
- NCT03287921
- Testing
- mono bronchodilatation, dual bronchodilatation
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Universitätsmedizin Mannheim
Non Small Cell Lung Cancer
Microbiota and the Lung Cancer
The subject is to study the lung microbiota and the one of upper airways (UAs) (much less studied than the intestinal microbiota) in 40 patients having lung cancer.
- Trial name
- MICA (NCT03068663)
- Testing
- Sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Jean Perrin
Asthma
Efficacy of QVAR vs Flovent Diskus on Small Airways in Poorly Controlled Asthmatic Adolescents/Adult Patients
The primary objective of this study is to evaluate the effect of Beclomethasone dipropionate HFA on small airways compared to Fluticasone propionate powder for inhalation administered twice daily to poorly controlled asthmatics.
- Trial name
- NCT00071552
- Testing
- Qvar, Flovent Diskus
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Lung Function Testing, Cigarette Smoking
Evaluation of Ventilation Homogeneity as a Marker of Small Airway Disease in Active Smokers
Ventilation heterogeneity is a hallmark feature of most obstructive pulmonary diseases. In particular, chronic obstructive pulmonary disease (COPD) is pathologically and physiologically characterized by small airway destruction…
- Conditions
- Lung Function Testing, Cigarette Smoking, Single-photon Emission Computed Tomography (SPECT), Ventilation Homogeneity
- Trial name
- NCT03728712
- Testing
- SPECT/CT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Asthma, COPD
Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease
The aim of the project is to study pathogenetic mechanisms in severe asthma and compare those mechanisms in chronic obstructive pulmonary disease (COPD) in order to test the hypothesis that severe asthma and COPD develop into…
- Trial name
- BIOAIR (NCT00555607)
- Testing
- prednisolone
- Where
- Sweden
- Volunteers
- 233 people
- Sponsor
- Karolinska Institutet
COPD (Chronic Obstructive Pulmonary Disease)
Singing Intervention for Chronic Obstructive Pulmonary Disease (COPD)
Why is this study being done? Chronic Obstructive Pulmonary Disease (COPD) causes airflow blockage creating breathing issues, distress, and lower well-being. COPD also causes hyperinflation of the lungs.
- Trial name
- EMPOWER (NCT07563283)
- Testing
- singing intervention for COPD
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Kansas Medical Center
Asthma
Small Airway Inflammation and Dysfunction in Different Asthma Phenotypes
Small airway inflammation and dysfunction will be measured in 40 children and 40 adults with asthma before and after 8 weeks of treatment with inhaled budesonide.
- Trial name
- NCT03718793
- Testing
- Peripheral exhaled nitric oxide
- Where
- Finland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital