Clinical trials: Small Airway Disorders
COVID-19
Small Airway Disease And Bronchial Hyperreactivity In Patients With Post Acute Covid-19 Syndrome
The aim of this work is to estimate the frequency of small airway disease and/or the bronchial hyperreactivity in follow up of postacute covid survivors.
- Trial name
- NCT06374420
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Asthma
Small Airway Function of Fluticasone/Formoterol (Flutiform®) and Fluticasone/Salmeterol
The purpose of this study is to demonstrate superiority of Fluticasone/Formoterol (Flutiform®) to Fluticasone/salmeterol based on the small airway function by assessing the Impulse Oscillometic System (IOS) in uncontrolled asthma…
- Trial name
- RECONFFIRM (NCT02491970)
- Testing
- Fluticasone/Formoterol, Fluticasone/Salmeterol
- Volunteers
- 15 people
- Sponsor
- Mundipharma Korea Ltd
COPD
Diagnostic and Therapeutic Approaches to Hyperinflation and Small Airway Disease in COPD
Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. Hyperinflation and affection of the small airways are two components that are not represented in current…
- Trial name
- NCT03287921
- Testing
- mono bronchodilatation, dual bronchodilatation
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Universitätsmedizin Mannheim
Non Small Cell Lung Cancer
Microbiota and the Lung Cancer
The subject is to study the lung microbiota and the one of upper airways (UAs) (much less studied than the intestinal microbiota) in 40 patients having lung cancer.
- Trial name
- MICA (NCT03068663)
- Testing
- Sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Jean Perrin
Asthma
Efficacy of QVAR vs Flovent Diskus on Small Airways in Poorly Controlled Asthmatic Adolescents/Adult Patients
The primary objective of this study is to evaluate the effect of Beclomethasone dipropionate HFA on small airways compared to Fluticasone propionate powder for inhalation administered twice daily to poorly controlled asthmatics.
- Trial name
- NCT00071552
- Testing
- Qvar, Flovent Diskus
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Lung Function Testing, Cigarette Smoking
Evaluation of Ventilation Homogeneity as a Marker of Small Airway Disease in Active Smokers
Ventilation heterogeneity is a hallmark feature of most obstructive pulmonary diseases. In particular, chronic obstructive pulmonary disease (COPD) is pathologically and physiologically characterized by small airway destruction…
- Conditions
- Lung Function Testing, Cigarette Smoking, Single-photon Emission Computed Tomography (SPECT), Ventilation Homogeneity
- Trial name
- NCT03728712
- Testing
- SPECT/CT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
COPD (Chronic Obstructive Pulmonary Disease)
Singing Intervention for Chronic Obstructive Pulmonary Disease (COPD)
Why is this study being done? Chronic Obstructive Pulmonary Disease (COPD) causes airflow blockage creating breathing issues, distress, and lower well-being. COPD also causes hyperinflation of the lungs.
- Trial name
- EMPOWER (NCT07563283)
- Testing
- singing intervention for COPD
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Kansas Medical Center
Asthma
Small Airway Inflammation and Dysfunction in Different Asthma Phenotypes
Small airway inflammation and dysfunction will be measured in 40 children and 40 adults with asthma before and after 8 weeks of treatment with inhaled budesonide.
- Trial name
- NCT03718793
- Testing
- Peripheral exhaled nitric oxide
- Where
- Finland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Asthma
A Case-control Study on the Differentiation Between Cough Variant Asthma and Chronic Cough
this study aimed to compare characters in pulmonary function of patients with cough variant asthma and chronic cough and establish a diagnostic model.
- Trial name
- NCT06199830
- Testing
- positive bronchial provocation test
- Where
- China
- Volunteers
- 645 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
COPD
Impact of Aerobika OPEP in Improving Small Airway Parameters in COPD
Research Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease that makes breathing difficult with mucus build-up in the inflamed airway and lungs hyperinflation due to expiratory flow…
- Trial name
- NCT05420740
- Testing
- Aerobika OPEP
- Where
- Malaysia
- Volunteers
- 53 people
- Sponsor
- National University of Malaysia
Obesity
Expiratory Airflow Limitation in Subjects With Obesity
The purpose of this study is to investigate posture dependent small airway obstruction in subjects with obesity, and to study the capacity of FOT as a measurement tool for small airways obstruction.
- Trial name
- EFL (NCT00865293)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Cystic Fibrosis
Bronchial Inflammation of Small Airways in Patients With Cystic Fibrosis
In the planned study, 60 patients with mild cystic fibrosis (CF) with and without the involvement of small airways (small airway disease - SAD) are to be compared with a historical control group matched in age and gender.
- Trial name
- FRA-MUKO (NCT01479166)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
COPD, COPD, Early-Onset
Change in Airway Peripheral Tone in COPD
Small airways disease is a pathological feature in mild to moderate COPD, which might be causally involved in disease progression.
- Trial name
- CAPTO-COPD (NCT04166812)
- Testing
- oscillometry, multiple breath washout testing, spirometry
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Heidelberg University
Copd
FEV1/FEV6 and FEV6 as an Alternative for FEV1/FVC and FVC in Bolivian Subjects
Comparison of FEV1/FEV6 and FEV6 as an alternative for FEV1/FVC and FCV in the detection of airway obstruction in a Bolivian population
- Trial name
- NCT03534557
- Testing
- FEV6 spirometry
- Where
- Bolivia
- Volunteers
- 70 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Thoracic Cancer
Bronchial Mapping (GCC 1635)
In order to better understand radiation-induced lung toxicity, the investigator proposes a novel functional avoidance approach that incorporates central as well as peripheral BSS segments in the treatment planning process in…
- Trial name
- NCT02745548
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Maryland, Baltimore
Chronic Obstructive Pulmonary Disease
The Effect of Beclomethasone/Formoterol in Extra-fine Formulation on Quality of Life and SAD in COPD Patients.
In patients with chronic obstructive pulmonary disease (COPD), small-airway dysfunction (SAD) is considered a key element and a functional consequence of the pathology.
- Trial name
- NCT04421742
- Testing
- Beclomethasone Dipropionate/Formoterol Fumarate
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Alfredo Antonio Chetta
Early Adult Lung Function, Small Airway Disease
Factors Affecting Early Adult Lung Function
Attainment of peak healthy lung function during the 18-26 yr window is a strong determinant of the rate of lung function decline during the later years of life.
- Conditions
- Early Adult Lung Function, Small Airway Disease, Metabolic Syndrome
- Trial name
- FEAL (NCT03187158)
- Testing
- Forced Oscillation Technique
- Where
- India
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Council of Scientific and Industrial Research, India
Cystic Fibrosis,
Evaluation of Bronchial Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA)
Chronic bronchial inflammation is an important clinical feature in cystic fibrosis. Approximately 10% of patients with cystic fibrosis suffer from Allergic Bronchopulmonary Aspergillosis.
- Trial name
- ABPA (NCT00906568)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Non-Small Cell Lung Cancer
Bronchoscopic Cryoablation Combined With Chemo-Immunotherapy in NSCLC With Central Airway Obstruction
This study aimed to evaluate the efficacy and safety of bronchoscopic cryoablation combined with sintilimab plus platinum-based chemotherapy as First-line Treatment for locally advanced or metastatic NSCLC with central airway…
- Trial name
- Example (NCT06604351)
- Testing
- Sintilimab, Nab-Paclitaxel, and Carboplatin
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Hunan Province Tumor Hospital
Small Airways Diseases, Vaping
The Canadian Lung Outcomes in Users of Vaping Devices Study
Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient…
- Conditions
- Small Airways Diseases, Vaping, Vaping Related Disorder, Vaping Teens
- Trial name
- CLOUD (NCT06819969)
- Where
- 8 sites in Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia