Clinical trials: Small Airway Disorders
Asthma
Determining the Optimal Adenosine Provocation Test
Asthma is a frequently occurring inflammatory lung disease that affects the whole bronchial tree including the small airways (<2mm).
- Trial name
- impact (NCT01610921)
- Testing
- Bronchial provocation test
- Where
- 2 sites in Netherlands
- Volunteers
- 11 people
- Sponsor
- University Medical Center Groningen
Bronchial Asthma
Effects on Small Airways of Two Long-term Extrafine Treatments in Asthma
New formulations of extrafine particles of long acting beta-2 agonists+inhaled corticosteroids (LABA+ICS) are able to reach more peripheral regions of the lung.
- Trial name
- FORTINO (NCT01255579)
- Testing
- Salmeterol Fluticasone, formoterol - beclometasone
- Volunteers
- 10 people
- Sponsor
- Università degli Studi di Brescia
Asthma
A Study in Patients With Asthma
The purpose of the present study is to demonstrate the higher efficacy of Foster® NEXThaler® 100/6 extra fine (two inhalations b.i.d.) versus Seretide® Accuhaler® 250/50 (one inhalation b.i.d.), in terms of pulmonary function…
- Trial name
- NELSON (NCT01570478)
- Testing
- Foster® NEXThaler® 100/6 µg/unit dose, Seretide® Accuhaler® 250/50 µg/actuation
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Non-Small Cell Lung Cancer, Chronic Obstructive Lung Disease
Singing Training vs Usual Care 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC)
People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning.
- Trial name
- Sing-a-Lung 2 (NCT07460999)
- Testing
- Singing training (Singing for Lung Health (SLH)), Control group: Usual care
- Where
- 5 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
COPD
Impact of Aerobika OPEP in Improving Small Airway Parameters in COPD
Research Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung disease that makes breathing difficult with mucus build-up in the inflamed airway and lungs hyperinflation due to expiratory flow…
- Trial name
- NCT05420740
- Testing
- Aerobika OPEP
- Where
- Malaysia
- Volunteers
- 53 people
- Sponsor
- National University of Malaysia
Chronic Obstructive Pulmonary Disease, Lower Respiratory Disease
Small Airway Chronic Obstructive Disease Syndrome Following Exposure to WTC Dust
Many "Survivors" in the World Trade Center (WTC) clinical program have a clinical syndrome characterized by chronic obstruction in small airways and persistence of lower respiratory symptoms despite therapy.
- Trial name
- NCT03089515
- Testing
- Cardio-Pulmonary Exercise Testing (CPET)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Asthma
Efficacy of Ciclesonide on Small Airways in Patients With Stable Asthma (18 to 60 y) (BY9010/M1-131)
The aim of this study is to evaluate the involvement of small airways in asthma, as determined by bronchial challenges, CT-scanning, and cellular markers of inflammation. Ciclesonide will be inhaled at one dose level once daily.
- Trial name
- NCT00163345
- Testing
- Ciclesonide
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Apnea, Airway Obstruction, Nasal
Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion
Breathing is a crucial function for everyone. Breathing impairment in children could lead to behavioral and cognitive problems at least.
- Conditions
- Apnea, Airway Obstruction, Nasal, Mandible Small, Maxillary Hypoplasia
- Trial name
- NCT04190953
- Testing
- Twin block then Hyrax, Hyrax then Twin block
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Asthma
A Study to Evaluate the Effect of Fluticasone/Formoterol Breath Actuated Inhaler (BAI) or Relvar® Ellipta® DPI on Ventilation Heterogeneity in Asthma
The purpose of this study is to demonstrate improvement of peripheral airway resistance (R5-R20) from baseline with fluticasone/formoterol breath actuated inhaler (BAI).
- Trial name
- NCT02753712
- Testing
- Fluticasone/Formoterol BAI, Fluticasone/Vilanterol DPI (Relvar Ellipta DPI)
- Where
- 16 sites in Australia, New Zealand and 3 more
- Volunteers
- 105 people
- Sponsor
- Mundipharma Research Limited
Locally Advanced Lung Carcinoma, Non-Small Cell Lung Carcinoma
Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer
This Phase I/Il studies the side effects of endobronchial ultrasound guided interstitial photodynamic therapy work in treating patients with lung cancer that has spread to nearby tissues or lymph nodes.
- Conditions
- Locally Advanced Lung Carcinoma, Non-Small Cell Lung Carcinoma, Small Cell Lung Carcinoma, Stage III Lung Cancer AJCC v8
- Trial name
- NCT03735095
- Testing
- Porfimer Sodium, Ultrasound-Guided Transbronchial Needle-Delivered Interstitial Photodynamic Therapy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Roswell Park Cancer Institute
COPD, Asthma
Imaging Lung Function Using Oxygen Enhanced MRI
The goal of this study is to perform a pilot study to evaluate the utilization of oxygen as an inhaled contrast agent to image the airway spaces in normal and diseased human lungs to allow an effect size estimate to power future…
- Conditions
- COPD, Asthma, Cystic Fibrosis, Emphysema
- Trial name
- NCT01731015
- Testing
- Medical Grade Oxygen
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hal C Charles
COPD Exacerbation Acute
Airway Inflammation, Small Airways Dysfunction, and Frequency of Exacerbations in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable, and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities…
- Trial name
- NCT06040931
- Testing
- Bronchoscopy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University Hospital
Pulmonary Disease, Chronic Obstructive, Emphysema
Evaluating the Clinical Effectiveness of 3D Printing for a Patient-specific Silicone Stent Airway Implant
The goal of the small feasibility trial is to establish a method, material, and patient-specific design that is superior to what is in use today.
- Trial name
- NCT03111888
- Testing
- Silicone Stent Airway Implant
- Where
- United States
- Sponsor
- The Cleveland Clinic
Chronic Obstructive Pulmonary Disease
The Effect of Beclomethasone/Formoterol in Extra-fine Formulation on Quality of Life and SAD in COPD Patients.
In patients with chronic obstructive pulmonary disease (COPD), small-airway dysfunction (SAD) is considered a key element and a functional consequence of the pathology.
- Trial name
- NCT04421742
- Testing
- Beclomethasone Dipropionate/Formoterol Fumarate
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Alfredo Antonio Chetta
Chronic Obstructive Pulmonary Disease (COPD)
Nitric Oxyde Concentration in Chronic Obstructive Pulmonary Disease Patients - SANOB Study
Among many other causes, Bronchial obstruction in Chronic Obstructive Pulmonary Disease (COPD) is also caused by inflammation of peripheral airways walls.
- Trial name
- SANOB (NCT01853787)
- Testing
- Formoterol Fumarate, Salmeterol
- Where
- 2 sites in Italy
- Volunteers
- 49 people
- Sponsor
- University of Milan
COPD
TRIMBOW® and RELVAR® on Lung Stiffness Reduction Assessed Through Forced Oscillation Technique in Patients With COPD
Efficacy of TRIMBOW® pMDI and RELVAR® ELLIPTA® DPI on lung stiffness reduction assessed through area under the reactance curve (AX) using oscillometry in chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04671355
- Testing
- Beclometasone Dipropionate / Formoterol Fumarate / Glycopyrronium 100/6/10 mcg, Fluticasone Furoate / Vilanterol Trifenatate 100/25 mcg
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma
Investigation of Novel Procedure for Methacholine Challenge Testing
The study will compare a novel volumetric method (performed with the Aerogen Solo vibrating mesh nebulizer) with the standard two-minute tidal breathing protocol (performed with the Wright jet nebulizer) for methacholine…
- Trial name
- NCT02965482
- Testing
- Wright Nebulizer, Aerogen Solo Nebulizer
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Saskatchewan
COPD, COPD, Early-Onset
Change in Airway Peripheral Tone in COPD
Small airways disease is a pathological feature in mild to moderate COPD, which might be causally involved in disease progression.
- Trial name
- CAPTO-COPD (NCT04166812)
- Testing
- oscillometry, multiple breath washout testing, spirometry
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Heidelberg University
Asthma
Additive Effects of QVAR to (Seretide) on Surrogate Markers of Airway Inflammation in Refractory Asthma
The purpose of this study is to establish whether addition of extra-fine particle steroid inhalers achieve additional suppression of small airways inflammation when added to 'standard' Fluticasone/Salmeterol combination therapy…
- Trial name
- PAW01 (NCT00829257)
- Testing
- HFA-BDP, Fluticasone, Seretide
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Dundee
Non-small Cell Lung Cancer, Lung Function Decreased
Effects of Nonintubated Thoracoscopic Lobectomy on Lung Protection
A novel nonintubated thoracoscopic technique is promising to enhance recovery after thoracic surgery. However, the effects of nonintubated technique on specific organ protection in not clear yet.
- Conditions
- Non-small Cell Lung Cancer, Lung Function Decreased, Tracheal Intubation Morbidity
- Trial name
- NCT03471884
- Testing
- Nonintubated thoracoscopic lobectomy, Intubated thoracoscopic lobectomy
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- National Taiwan University Hospital