Clinical trials: Small Bowel Crohn's Disease
Crohn Disease of Small Intestine
Defining Predictors of RT Response to Vedolizumab in IBD
The overall goal of the study is to develop data that can convincingly guide clinicians on the use and efficacy of vedolizumab in patients with small bowel CD.
- Trial name
- NCT03142321
- Testing
- Vedolizumab 300 MG Injection [Entyvio]
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
Crohn Disease
Trial Evaluating the Diagnostic Usefulness of Lumentin® 44 When Used as Contrast Agent
The trial is a phase 2 randomised, open, non-inferiority within patient-controlled multi-centre trial. Male and female subjects with a diagnosis of Crohn´s Disease and a clinical indication for an MRE examination, who are at…
- Trial name
- NCT04321941
- Testing
- Lumentin, Movprep
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Lument AB
Rheumatoid Arthritis, Crohn's Disease
Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium Absorption
This study is a pilot study to determine whether patients with TNFα excess have decreased calcium absorption in response to calcitriol (1,25-dihydroxyvitamin D, the active form of vitamin D) compared to normal controls.
- Trial name
- NCT00427804
- Testing
- calcitriol
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Atlanta VA Medical Center
Crohn's Disease
Effect of Glutamine on Intestinal Permeability in Crohn's Disease
The purpose of this study is to see whether enteral glutamine supplementation improves intestinal permeability and small intestinal morphology in patients with Crohn's disease.
- Trial name
- NCT00838149
- Testing
- Glutamine, Whey protein
- Where
- India
- Volunteers
- 30 people
- Sponsor
- All India Institute of Medical Sciences
Inflammatory Bowel Disease
Tracking the Natural Course of Silent Small Bowel Narrowing in Adults With Crohn's Disease
Crohn's disease is a long-term condition that causes inflammation in the digestive tract. Over time, some people develop narrowings in the small intestine, called "strictures." These strictures can block food and cause symptoms…
- Trial name
- SILENCE (NCT07167745)
- Where
- Serbia
- Volunteers
- 150 people
- Sponsor
- University Medical Center Zvezdara
Crohn's Disease
An Efficacy and Safety Study of Omega-3 Free Fatty Acids (Epanova™) for the Maintenance of Symptomatic Remission in Subjects With Crohn's Disease
The purpose of this study is to see if Epanova™ is able to maintain the symptomatic remission in subjects with Crohn's Disease who are responding to steroid induction therapy.
- Trial name
- NCT00074542
- Testing
- Epanova™ (Omega-3 Free Fatty Acids)
- Where
- 31 sites in United States, Canada
- Volunteers
- 364 people
- Sponsor
- Tillotts Pharma AG
Crohn's Disease
Study Evaluating AZD7798 for Treatment in Crohn's Disease Patients With an Ileostomy
The purpose of this study is to evaluate safety, tolerability, and effect on mucosal repair of AZD7798 compared with placebo in participants with active ileal Crohn's disease and an ileostomy.
- Trial name
- CALLISTO (NCT06681324)
- Testing
- AZD7798
- Where
- 17 sites in Belgium, Italy and 5 more
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Crohn Disease, Stricture; Bowel
Endoscopic Stricturotomy Versus Endoscopic Balloon Dilatation in Patients With Crohn's Disease and Symptomatic Small Bowel Stricture
Stenosis is one of the most frequent complications in patients with Crohn's disease (CD). In particular, CD patients with intestinal strictures are often faced with short bowel syndrome after repeated or extensive surgical…
- Conditions
- Crohn Disease, Stricture; Bowel, Endoscopy, Gastrointestinal
- Trial name
- DESTRESS (NCT05009212)
- Testing
- Endoscopic stricturotomy, Endoscopic balloon dilatation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn Disease
Early MRI Prediction of Crohns
The investigators plan a prospective study designed to optimize and translate noncontrast, novel Magnetic Resonance Imaging (MRI) techniques for detecting and measuring intestinal inflammation as well as for allowing early…
- Trial name
- NCT03340519
- Testing
- MR Imaging
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Urine Metabolites in the Diagnosis of Disease
The goal of this observational study is to validate a non-invasive, urine-based diagnostic technology for the detection and differentiation of various gastrointestinal (GI) diseases.
- Conditions
- Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Crohn Disease, Celiac Disease
- Trial name
- NCT06710067
- Where
- 4 sites in United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Luventix, Inc.
Kidney Calculi, Crohn's Disease
Calcium Supplements Strategy for Kidney Stones Prevention in Crohn's Patients
Hospitalization for kidney stones in the Inflammatory Bowel Disease (IBD) population is common, particularly among Crohn's patients who had a small bowel resection.
- Trial name
- NCT01735461
- Testing
- Calcium Carbonate
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Crohn Disease Located in Jejunum or Ileum
Endoscopic Detection of Dysplasia in Crohn 's Disease Patient
Patients with Crohn's disease (CD) have an increased risk of small bowel adenocarcinoma (SBA). Long duration of CD is the main risk factor.
- Trial name
- DYDJI (NCT01180452)
- Testing
- enteroscopy
- Where
- 15 sites in France
- Volunteers
- 107 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Autoimmune Diseases, Non-small Cell Lung Cancer
Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease
The purpose of this study is to explore the safety, tolerability and activity of Nivolumab, a PD-1 inhibitor, in cohorts of patients with autoimmune disease.
- Conditions
- Autoimmune Diseases, Non-small Cell Lung Cancer, Rheumatoid Arthritis, Psoriasis
- Trial name
- NCT03656627
- Testing
- Nivolumab
- Where
- 9 sites in United States
- Volunteers
- 7 people
- Sponsor
- Alliance Foundation Trials, LLC.
Disorder of Small Intestine, Gastrointestinal Hemorrhage
European Novel Motorized Spiral Endoscopy Trial
The subject Novel Motorized Spiral Enteroscope (NMSE) represents a new technology which offers all of the advantageous options of spiral enteroscopy with a faster and less invasive approach.
- Conditions
- Disorder of Small Intestine, Gastrointestinal Hemorrhage, Iron Deficiency Anaemia, Crohn's Disease
- Trial name
- ENMSET (NCT02965209)
- Testing
- motorized spiral enteroscopy
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Evangelisches Krankenhaus Düsseldorf
Crohn's Disease
Capsule Endoscopy Crohn's Disease Activity Index - Validation Multi Center Study
The Study 1. Prospective trial of the Niv score validating score against known activity indices - see addendum A for Niv score 2.
- Trial name
- NCT00596700
- Testing
- Given® Diagnostic System including PillCamTM SB Capsules
- Where
- 4 sites in Ireland, Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Crohn Disease, Inflammatory Bowel Diseases
Investigation of VAP-1 Expression and Tissue Blood Flow by PET-MRI in Patients With Crohn's Disease
This is an observational, single center, imaging study. The CD patients with active disease will be assessed by [68Ga]Ga-DOTA-Siglec-9 and [15O]H2O PET/MRE.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Crohn Disease of Small Intestine, Crohn Colitis
- Trial name
- VAP-PET (NCT06555042)
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Turku University Hospital
Digestive System Disease, Inflammatory Bowel Diseases
Comparative Study of Intestinal Color Ultrasound and Capsule Endoscopy in Monitoring Crohn's Disease
The disease activity index under intestinal color ultrasound was evaluated by SUS-CD, and the disease activity index under capsule endoscopy was evaluated by CECDAI.
- Conditions
- Digestive System Disease, Inflammatory Bowel Diseases, Crohn Disease, Crohn Disease of Small Intestine
- Trial name
- NCT05636657
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic Inflammatory Small Bowel Disease, Crohn's Disease
PillCam SBC System Functionality in Established and Suspected IBD Patients
This clinical study is designed to evaluate the PillCam SBC system performance in 50 established or suspected inflammatory bowel disease (IBD) patients by visualizing and assessing their small and large bowel.
- Trial name
- PIANO (NCT02742714)
- Testing
- PillCam SBC system
- Where
- 5 sites in Israel, Italy and 1 more
- Volunteers
- 54 people
- Sponsor
- Medtronic - MITG
Inflammatory Bowel Diseases
MACCS: Multicenter Australian CE in Patients With Suspected Crohn's Disease Study
This is a prospective study aimed to validate the ability of capsule endoscopy to accurately diagnose small bowel Crohn's disease in symptomatic patients who have a non-diagnostic standard workup.
- Trial name
- MACCS (NCT00434551)
- Where
- 8 sites in Australia
- Volunteers
- 119 people
- Sponsor
- Medtronic - MITG
Crohn Disease, Upadacitinib
Upadacitinib in Isolated Small Bowel Versus Non-Small Bowel Crohn's Disease
Background \& Aims: Isolated small bowel Crohn's disease (CD) is defined by involvement of the ileum, jejunum, or extensive small intestinal segments in the absence of colonic disease.
- Trial name
- NCT07597577
- Testing
- Upadacitinib
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University