Clinical trials: Small Fiber Neuropathy, open to volunteers
Neuropathy, Diabetic, Small Nerve Fiber Neuropathy
Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy
Predicting early onset neuropathy in people with type 1 diabetes
- Conditions
- Neuropathy, Diabetic, Small Nerve Fiber Neuropathy, Type 1 Diabetes
- Trial name
- NeuroPredict (NCT05546138)
- Testing
- Skin biopsies with quantification of intra-epidermal nerve fibre density, Perception Threshold Tracking, Thermal perception thresholds
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aalborg University Hospital
Small Fiber Neuropathy
Magnetic Brain Stimulation in Small Fiber Neuropathy
Small fiber neuropathy (SFN) is a condition in which the smallest nerve fibers are damaged. This leads to severe pain and disturbances in the body's automatic functions.
- Trial name
- rTMS in SFN (NCT07805057)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Carpal Tunnel Syndrome
Small Nerve Fiber Activity in Patients with Carpal Tunnel Syndrome Assessed Via Quantitative Sensory Testing
The diagnosis of carpal tunnel syndrome (CTS) is typically based on clinical findings and confirmatory electrodiagnostic testing. However, electrodiagnostic testing can only assess large A-alpha and A-beta nerve fibers.
- Trial name
- NCT06550284
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Brooke Army Medical Center
Neuropathy, Small Fiber, Diabete Mellitus
Effect of Tirzepatide on Diabetic Peripheral Sensorimotor Neuropathy
Tirzepatide is a dual agonist of GLP-1 Receptor and the GIP receptor, producing substantial improvement in glycaemic control, weight reduction and insulin sensitivity.
- Trial name
- T-DPN (NCT07706088)
- Testing
- Tirzepatide 2.5mg weekly, all standard of care to diabetic patient besides tirzepatide
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Pain Syndrome
Fibromyalgia and Small Fiber Neuropathy
The primary objective of this study will be to assess the proportion of fibromyalgia patients with diffuse small-fiber neuropathy (i.e.
- Trial name
- FIBRO-NEP (NCT06527183)
- Testing
- Skin punch biopsy to demonstrate small fiber neuropathy
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital Ambroise Paré Paris
Primary Sjögren Syndrome, Small Fiber Neuropathy
Medico-economic and Quality of Life Impact of Sjogren-associated Small Fiber Neuropathy
BACKGROUND Sjögren's syndrome is an autoimmune disease whose prevalence is estimated between 200 and 500 patients per 100,000 persons in France (120 to 500,000 patients).
- Conditions
- Primary Sjögren Syndrome, Small Fiber Neuropathy, Quality of Life, Medico-economic Impact
- Trial name
- SFINESS-QoLEco (NCT03509064)
- Testing
- Collection sheet
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autonomic Neuropathy, Ehlers-Danlos Syndrome Hypermobility Type
Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry
We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the…
- Conditions
- Autonomic Neuropathy, Ehlers-Danlos Syndrome Hypermobility Type, Small Fiber Neuropathy, Postural Tachycardia Syndrome
- Trial name
- ProANS (NCT04310644)
- Testing
- No intervention planned, but all patients get our standart treatment
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- RWTH Aachen University
Small Fiber Neuropathy, Autoimmune Small Fiber Neuropathy
IVIG in the Treatment of Autoimmune Small Fiber Neuropathy With TS-HDS, FGFR-3, or Plexin D1 Antibodies
This study will enroll patients with small fiber neuropathy (SFN). The study will look at an intravenous immunoglobulin (IVIG) called Panzyga.
- Conditions
- Small Fiber Neuropathy, Autoimmune Small Fiber Neuropathy, Inflammatory Polyneuropathy, Immune-Mediated Neuropathy
- Trial name
- NCT04153422
- Testing
- Panzyga IVIG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Health
Diabetic Peripheral Neuropathy
Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy
This is a prospective randomized control trial. Participants enrolled into the study will be randomized into one of three groups, two of which are treatment groups and the third is a control group.
- Trial name
- NCT06287736
- Testing
- Spinal Cord Stimulator Implantation (SCS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Small Fiber Neuropathy
Detection of Small Fiber Neuropathy Using Skin Properties
Small fiber neuropathy affects millions of peoples worldwide. The neuropathy is causing disabling burning pain and dysautonomia such as dizziness with standing, brain fog, fatigue, constipation, too much or too little sweating.
- Trial name
- NCT04759443
- Testing
- Image processing of skin
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Breast Neoplasm
Preventing Chemotherapy-induced Peripheral Neuropathy Using PRESIONA Exercise Program
The aim of this study is to determinate if therapeutic exercise with blood flow restriction (BFR) during neoadjuvant chemotherapy potentialy neurotoxic could prevent the onset of chemotherapy induced peripheral neuropathy (CIPN)…
- Trial name
- PRESIONA (NCT04652609)
- Testing
- PRESIONA
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidad de Granada
Sensory Neuropathy, Small Fiber Neuropathy
IVIG in Painful Sensory Neuropathy
The goal of this clinical trial is to assess effect of Intravenous immunoglobulins (antibodies) as compared to Placebo, on pain intensity in patients from 18-65 years with painful sensory neuropathy without a known cause.
- Trial name
- NCT06183008
- Testing
- Intravenous immunoglobulin
- Volunteers
- 20 people
- Sponsor
- Sorlandet Hospital HF
Small Fiber Neuropathy
Pilot Study to Evaluate Changes in Intra-Epidermal Nerve Fiber Density (IENFD) in Patients With Small-Fiber Neuropathy
This prospective observational pilot study will evaluate structural, functional, and patient-reported outcomes in adults with small fiber neuropathy who receive Saluda Evoke ECAP-controlled spinal cord stimulation as part of…
- Trial name
- SAL SFN PILOT (NCT07704931)
- Testing
- Evoke SCS system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- TriCity Research Center
Sjögren's Syndrome, Small Fiber Neuropathy
Evaluation of the Prevalence, and Immunological Characteristics of Small Fiber Neuropathy in Patients With Primary Sjögren's Syndrome
The investigators propose to conduct a prospective study evaluating the prevalence of SNN in pSS patients and to find clinical characteristics and specific immunological profiles in pSS patients with SFN.
- Conditions
- Sjögren's Syndrome, Small Fiber Neuropathy, Autonomic Dysfunction, Autoantibodies
- Trial name
- NEUROSS (NCT07917442)
- Testing
- Sudoscan testing
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens