Clinical trials: Small Intestinal Bacterial Overgrowth
Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth
The Efficacy of Probiotics as an Adjunct to Treatment of SIBO With Rifaximin
The goal of this clinical trial is to test the effectiveness of probiotic bacterial supplements as an additional therapeutic modality in patients with small intestine bacterial overgrowth who receive oral antibiotic treatment…
- Conditions
- Irritable Bowel Syndrome, Small Intestinal Bacterial Overgrowth, SIBO
- Trial name
- NCT06223685
- Testing
- Rifaximin (Xifaxan) 1200mg/day, Probiotic, XIFAXAN® (Rifaximin) 1600mg/day
- Where
- Poland
- Volunteers
- 129 people
- Sponsor
- Pomeranian Medical University Szczecin
Gastrointestinal Motility Disorder, Intestinal Disease
Lanreotide in the Treatment of Small Bowel Motility Disorders
This is a human research study looking at the effectiveness of Lanreotide (study medication) in treating small bowel motility disorders.
- Trial name
- NCT03012594
- Testing
- Lanreotide
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Northwell Health
Small Intestinal Bacterial Overgrowth, Irritable Bowel Syndrome
SIBO, Immune Activation, and FGIDs in Children
PURPOSE: This study will evaluate the relationships between small intestinal bacterial overgrowth (SIBO), immune activation, inflammation, and symptoms in pediatric abdominal pain-related functional gastrointestinal disorders…
- Conditions
- Small Intestinal Bacterial Overgrowth, Irritable Bowel Syndrome, Functional Dyspepsia, Functional Abdominal Pain
- Trial name
- SIBO (NCT02872961)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- The University of Texas Health Science Center, Houston
Small Intestinal Bacterial Overgrowth
Feasibility of a New Diagnostic Device to Assess Small Intestinal Dysbiosis in Routine Clinical Setting.
The purpose of this study is to determine if the gas-sensing capsule can be used to identify increased numbers and a change of the composition of microbiota or microorganisms in the gut to assess small intestinal dysbiosis
- Trial name
- NCT04910815
- Testing
- Atmo Gas Capsule, Glucose Breath Test, Fructoolifosaccharides (FOS) Breath Test
- Where
- 2 sites in Australia, India
- Volunteers
- 150 people
- Sponsor
- Atmo Biosciences Pty Ltd
Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Small Bowel Bacterial Overgrowth Syndrome (SBBOS)
Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing
The objective of this study is to compare the efficacy of prokinetics versus antibiotics versus a combination of antibiotics plus prokinetics in the eradication of Small-Intestinal Bacterial Over-Growth Syndrome (SIBO) in those…
- Trial name
- SIBO (NCT01324895)
- Where
- United States
- Volunteers
- 944 people
- Sponsor
- University of Florida
Cirrhosis, Liver, Minimal Hepatic Encephalopathy
Rifaximin's Effect on Covert Hepatic Encephalopathy With SIBO and Gastrointestinal Dysmotility
Small Intestinal Bacterial Overgrowth (SIBO) is a common and increasingly recognized disorder in cirrhosis (30% to 73%). One of the most important predisposing factors of SIBO is small bowel dysmotility.
- Conditions
- Cirrhosis, Liver, Minimal Hepatic Encephalopathy, Small Intestinal Bacterial Overgrowth, Gastrointestinal Motility Disorder
- Trial name
- NCT04244877
- Testing
- Rifaximin
- Sponsor
- MetroHealth Medical Center
Small Intestinal Bacterial Overgrowth Syndrome (SIBO), IBS
Effect of Multispecies Probiotic Supplementation on the Efficacy of Rifaximin α Therapy in Patients With Small Intestinal Bacterial Overgrowth (SIBO): a Randomized Placebo-controlled Trial
Small intestinal bacterial overgrowth (SIBO) is a common condition associated with gastrointestinal symptoms such as bloating, abdominal pain, diarrhea, and constipation, particularly in patients with irritable bowel syndrome.
- Trial name
- SIBO-Probiotic (NCT07426705)
- Testing
- Probiotic preparation, Rifaximin (drug)
- Volunteers
- 100 people
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji
Chronic Intestinal Pseudo-obstruction
Efficacy and Safety of Rifaximin for Patients With Chronic Intestinal Pseudo-obstruction: a Phase 2 Trial
The objective of the study is to investigate efficacy and safety of rifaximin (L-105) in patients with chronic idiopathic intestinal pseudo-obstruction(CIIPO) or patients with chronic intestinal pseudo-obstruction (CIPO)…
- Trial name
- NCT04118699
- Testing
- Rifaximin oral tablet
- Where
- Japan
- Volunteers
- 12 people
- Sponsor
- Yokohama City University
Small Intestinal Bacterial Overgrowth, Lactose Intolerance
Clinical Utility of Breath Tests in GI
Bloating, gas, pain and diarrhea are common complaints. Routine investigations are negative; these patients are labeled as IBS. In these patients, whether testing for carbohydrate malabsorption or small intestinal bacterial…
- Conditions
- Small Intestinal Bacterial Overgrowth, Lactose Intolerance, Fructose Intolerance, Glucose Intolerance
- Trial name
- NCT03261856
- Where
- United States
- Volunteers
- 1,080 people
- Sponsor
- Augusta University
Small Intestinal Bacterial Overgrowth
Hydrogen and Methane Breath Test Questionnaire
Lactulose HMBT and Glucose HMBT are simple non-invasive tests to assess whether imbalances in gut bacteria may be contributing to troublesome tummy symptoms.
- Trial name
- HMBTQ (NCT05122520)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 1,040 people
- Sponsor
- The Functional Gut Clinic
Parkinson's Disease, Small Intestinal Bacterial Overgrowth
Treating Bacterial Overgrowth in Parkinson's Disease
This study investigates the effect of treating Small Intestinal Bacterial Overgrowth (SIBO) in patients with Parkinson's Disease (PD).
- Trial name
- SIBO-PD (NCT02470780)
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati
Irritable Bowel Syndrome
A Longitudinal Study to Identify IBS Phenotypes Using Fecal Microbiota and Hydrogen Breath Testing
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a highly prevalent but poorly understood condition with limited treatment options.
- Trial name
- NCT03219528
- Testing
- Rifaximin 550 MG, Low FODMAP Diet
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Michigan
Small Intestinal Bacterial Overgrowth (SIBO)
Botanical Blend on the Gut Microbiome and Gut-Skin-Axis in Small Intestinal Bacterial Overgrowth (SIBO)
The purpose of this study is to assess how an oral botanical blend alters the gut microbiome and the skin biophysical properties in people with SIBO.
- Trial name
- NCT04867512
- Testing
- Liquid Tincture, GI Detox, Olivirex
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Irritable Bowel Syndrome, Abdominal Pain
Bifidobacterium Infantis M-63 Improves Mental Health in Irritable Bowel Syndrome Developed After a Major Flood Disaster
A 3-month study was conducted in flood victims from affected villages in the Tumpat district, Kelantan. Participants were given either probiotic, Bifidobacterium infantis M63 (M-63 group) or no probiotics (control group) for…
- Conditions
- Irritable Bowel Syndrome, Abdominal Pain, Small Intestinal Bacterial Overgrowth
- Trial name
- NCT03318614
- Testing
- Probiotics M-63, Control group
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Small Intestinal Bacterial Overgrowth
Comparative Assessment of Radioisotope Glucose and Breath Test
This is a research study about improving our diagnostic method for small intestinal bacterial overgrowth (SIBO). Patients undergoing Standard of Care (SOC) Endoscopically assisted glucose breath test (EAGBT) will undergo upper…
- Trial name
- NCT04499742
- Testing
- Using Isotope (Tc99m-Sulfur Colloid) to label glucose and administer this directly into duodenum.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Augusta University
Small Intestine Bacterial Overgrowth
Study of Clinical Features and Efficacy of Small Intestinal Bacterial Overgrowth in Patients With Abdominal Distension
Most studies of bloating have focused on functional factors, while data on organic abdominal distention are rare, and studies that combine small intestine bacterial overgrowth and/or oral cecum transit time abnormalities are more…
- Trial name
- NCT06518850
- Testing
- Rifaximin
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
SIBO, Pancreatic Insufficiency
Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy
Pancreatic exocrine insufficiency (PEI) results from reduced pancreatic enzyme secretion, leading to malabsorption, malnutrition, and impaired quality of life.
- Conditions
- SIBO, Pancreatic Insufficiency, Chronic Pancreatitis, Pancreatic Surgey
- Trial name
- DCP-PCT-EPI (NCT07479238)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colon Cancer
Chronic Loose Stools Following Right-sided Hemicolectomy for Colon Cancer and the Association With Bile Acid Malabsorption and Small Intestinal Bacterial Overgrowth Using a Novel Sampling Device
The goal of this clinical research study is to learn about gastrointestinal symptoms in participants who have undergone SC or RC and their impact on the quality of life of these participants.
- Trial name
- NCT06927011
- Testing
- Capscan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Small Intestinal Bacterial Overgrowth
Methane and Hydrogen Breath Test for the Diagnosis of Small Intestinal Bacterial Overgrowth
To investigate whether the positive rates of methane and hydrogen breath test were different between the experimental group and the control group.
- Trial name
- NCT06483360
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine