Clinical trials: Small Intestinal Bacterial Overgrowth, open to volunteers
Gastroesophageal Reflux, Regurgitation
A Study of Breath Testing for Small Intestinal Bacterial Overgrowth
Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.
- Conditions
- Gastroesophageal Reflux, Regurgitation, Heartburn
- Trial name
- NCT05976165
- Testing
- Breath Testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Comparison of the Efficacy of Saccharomyces Boulardii and Rifaximin in the Treatment of Small Intestinal Bacterial Overgrowth
This multicenter randomized controlled study aims to systematically evaluate the efficacy and safety of Saccharomyces boulardii sachets versus rifaximin in the treatment of small intestinal bacterial overgrowth (SIBO), with a…
- Trial name
- NCT07815548
- Testing
- Saccharomyces boulardii sachets, Rifaximin (Xifaxan)
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Shandong University
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Colon Cancer
Chronic Loose Stools Following Right-sided Hemicolectomy for Colon Cancer and the Association With Bile Acid Malabsorption and Small Intestinal Bacterial Overgrowth Using a Novel Sampling Device
The goal of this clinical research study is to learn about gastrointestinal symptoms in participants who have undergone SC or RC and their impact on the quality of life of these participants.
- Trial name
- NCT06927011
- Testing
- Capscan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Irritable Bowel Syndrome (IBS), Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Herbal Supplement (Biocidin REMOVE) for Bacterial Overgrowth in Irritable Bowel Syndrome
The goal of this clinical trial is to learn if an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS).
- Trial name
- NCT07768267
- Testing
- Biocidin REMOVE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Functional Dyspepsia, Small Intestinal Bacterial Overgrowth
Small Intestinal Bacterial Overgrowth: A Prospective Registry
The purpose of this study is to investigate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients who will be undergoing an enteroscopy as an outpatient procedure with symptoms of functional dyspepsia.
- Trial name
- SIBO (NCT01822470)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Urine Metabolites in the Diagnosis of Disease
The goal of this observational study is to validate a non-invasive, urine-based diagnostic technology for the detection and differentiation of various gastrointestinal (GI) diseases.
- Conditions
- Colorectal Cancer, Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Crohn Disease, Celiac Disease
- Trial name
- NCT06710067
- Where
- 4 sites in United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Luventix, Inc.
Pancreatic Adenocarcinoma, Weight Loss
Small Intestinal Bacterial Overgrowth (SIBO) in Pancreatic Adenocarcinoma (PDAC)
The purpose of this study is to prospectively analyze the prevalence of SIBO in patients with Pancreatic adenocarcinoma (PDAC) and understand its association with weight loss and pancreatic resection status.
- Trial name
- SIBO in PDAC (NCT06988150)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Autoimmune Gastritis
Assessing the Prevalence and Epidemiological Characteristics of Small Intestinal Bacterial Overgrowth (SIBO) in Patients With Autoimmune Gastritis(AIG) Through Hydrogen and Methane Breath Testing(HMBT).
Evaluate the prevalence of small intestinal bacterial overgrowth in patients with autoimmune gastritis (AIG) through hydrogen and methane breath testing, and determine whether there are differences in the positive rates of…
- Trial name
- HMBT、SIBO、AIG (NCT06946706)
- Testing
- hydrogen and methane breath testing
- Where
- China
- Volunteers
- 220 people
- Sponsor
- RenJi Hospital
Small Intestine Bacterial Overgrowth
Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children
The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.
- Trial name
- NCT07451171
- Testing
- Trimethoprim-sulfamethoxazole (TMP/SMX), Metronidazole, Amoxicillin-Clavulanate (4:1 formulation)
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Small Intestinal Bacterial Overgrowth Syndrome (SIBO)
Herbal Evaluation Of Artemisia Annua For Small Intestinal Bacterial Overgrowth
Small intestinal bacterial overgrowth (SIBO) can cause symptoms like bloating, stomach pain, and changes in bowel movements, significantly affecting quality of life.
- Trial name
- HERBA-SIBO (NCT06721884)
- Testing
- Artemisia Annua Leaf
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National University of Natural Medicine
Small Intestinal Bacterial Overgrowth
Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth
The objective of the study is to assess feasibility, and clinical efficacy of a novel Fecal Microbiota Transplantation protocol for the treatment of pediatric small intestinal bacterial overgrowth (SIBO).
- Trial name
- NCT05967871
- Testing
- Fecal Microbiota Transplant
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McMaster Children's Hospital
SIBO
Efficacy of Rifaximin in Patients With Small Intestinal Bacterial Overgrowth Presenting With Abdominal Bloating.
Abdominal bloating is a common clinical symptom in the digestive system, with obscure origins and complex mechanisms. Its etiology can be attributed to organic diseases and various Functional Gastrointestinal Disorders (FGIDs).
- Trial name
- NCT06772064
- Testing
- Rifaximin (drug)
- Where
- China
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Xiuli Zuo
Bacterial Overgrowth Syndrome Small Bowel, Heart Failure with Preserved Ejection Fraction
Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction
Single-center, double-blind, randomized, controlled intervention study of the effect of correction of bacterial overgrowth syndrome in the small intestine (SIBO) on cardiac function in patients with heart failure with preserved…
- Trial name
- SIBO-HFpEF (NCT06652087)
- Testing
- Rifaximin, Standard HFpEF treatment
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
SIBO, Pancreatic Insufficiency
Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy
Pancreatic exocrine insufficiency (PEI) results from reduced pancreatic enzyme secretion, leading to malabsorption, malnutrition, and impaired quality of life.
- Conditions
- SIBO, Pancreatic Insufficiency, Chronic Pancreatitis, Pancreatic Surgey
- Trial name
- DCP-PCT-EPI (NCT07479238)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Small Intestinal Bacterial Overgrowth
Evaluating the Effect Of Rifaximin on the Gut Microbiota and Metabolome in SIBO Using CapScan®
We will sample intestinal microbiota using a microbiome sampling capsule in patients with Small Intestinal Bacterial Overgrowth (SIBO)
- Trial name
- NCT06298409
- Testing
- CapScan collection capsule
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Envivo Bio Inc
Obesity and Overweight
Kombucha in Overweight and Obese: Live Vs. Pasteurized Effects on Microbiota, Metabolism, and Liver Function
Kombucha, a fermented beverage made from Camellia sinensis tea (black, oolong, or green) with sugar and a symbiotic culture of bacteria and yeast (SCOBY), has gained global attention for its potential health benefits.
- Trial name
- KOMBIOME (NCT06759324)
- Testing
- Live kombucha (non filtered/ non pasteurized), Pasteurized kombucha (non filtered), Control (sparkling water)
- Where
- 2 sites in Portugal
- Volunteers
- 33 people
- Sponsor
- Associação Centro de Apoio Tecnológico Agro Alimentar
Periodontitis (Stage 3), Periodontitis Stage IV
Characterization of Small Intestinal Bacterial Overgrowth and Intestinal Barrier-Related Biomarkers in Patients With Severe Periodontitis: A Pilot Prospective Longitudinal Observational Cohort Study
Periodontitis is a chronic inflammatory disease characterized by dysbiotic subgingival biofilms, inflammation, and progressive destruction of the tooth-supporting tissues.
- Conditions
- Periodontitis (Stage 3), Periodontitis Stage IV, SIBO
- Trial name
- MIRA (NCT07907224)
- Where
- Romania
- Volunteers
- 20 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Small Intestinal Bacterial Overgrowth Syndrome (SIBO), IBS
Effect of Multispecies Probiotic Supplementation on the Efficacy of Rifaximin α Therapy in Patients With Small Intestinal Bacterial Overgrowth (SIBO): a Randomized Placebo-controlled Trial
Small intestinal bacterial overgrowth (SIBO) is a common condition associated with gastrointestinal symptoms such as bloating, abdominal pain, diarrhea, and constipation, particularly in patients with irritable bowel syndrome.
- Trial name
- SIBO-Probiotic (NCT07426705)
- Testing
- Probiotic preparation, Rifaximin (drug)
- Volunteers
- 100 people
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji