Clinical trials: Small Pulmonary Nodules
Lung Cancer
Budesonide in Treating Patients With Lung Nodules at High Risk of Developing Lung Cancer
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of budesonide may keep lung cancer from forming in patients with lung nodules.
- Trial name
- NCT00321893
- Testing
- Budesonide
- Where
- Italy
- Volunteers
- 225 people
- Sponsor
- National Cancer Institute (NCI)
Lung Neoplasms, Lymph Node Excision
Mediastinal Lymph Node Dissection Versus Spared Mediastinal Lymph Node Dissection in Stage I GGN NSCLC
Lung cancer is the leading cause of cancer related death worldwide. Lobectomy or sub-lobectomy with mediastinal lymph node dissection is the standard surgery. About 50% lung nodules are pure ground-glass or part-solid nodules.
- Trial name
- NCT04631770
- Testing
- Systemic mediastinal lymph node dissection, Spared mediastinal lymph node dissection
- Where
- China
- Volunteers
- 1,362 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Multiple Pulmonary Nodules
Neoadjuvant Immunotherapy in Early Stage Non-small-cell Lung Cancer Presenting as Synchronous Ground-glass Nodules
Neoadjuvant Immunotherapy in Early Stage Non-small-cell Lung Cancer Presenting as Synchronous Ground-glass Nodules: a pilot study
- Trial name
- NCT04047186
- Testing
- Tislelizumab Injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- XiangNing Fu
Lung Cancer, Secondary Lung Cancer
Conventional Bronchoscopy Plus Rose Versus Electromagnetic Navigation (EMN) Plus Rose in Small Peripheral Lesions
The aim of this study is to evaluate if Electromagnetic navigation (ENB) in combination with rapid on site evaluation (ROSE) can improve diagnostic accuracy in those patients who fail to be diagnosed with conventional…
- Conditions
- Lung Cancer, Secondary Lung Cancer, Benign Lung Lesions
- Trial name
- NCT00880945
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Lung Cancer, Lung Nodule
Intraoperative Imaging of Pulmonary Nodules by SGM-101
The primary objectives of this study are to assess the sensitivity and specificity of SGM-101 in detecting non-small cell lung carcinomas during surgery when excited by an near-infrared light source utilizing intraoperative…
- Conditions
- Lung Cancer, Lung Nodule, Non Small Cell Lung Cancer
- Trial name
- NCT04315467
- Testing
- SGM-101, Near infrared camera imaging system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sunil Singhal
Lung Cancer (NSCLC)
Postoperative EGFR-TKI Therapy forContralateral Pulmonary Nodules in Patients With EGFR-Mutant NSCLC（ARMOR2501）
Background Synchronous multifocal primary lung cancer (sMPLC) presents a therapeutic challenge, particularly for bilateral lesions.
- Trial name
- ARMOR2501 (NCT06924398)
- Testing
- Postoperative EGFR-TKI Therapy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sun Yat-sen University
Pulmonary Function Assessment, Disease Free Survival
Pulmonary Watershed Topographic Map Navigation for Lung Nodule Resection
A method of ICG counterstaining localization under target artery occlusion without cutting，It's a new method of localization of small pulmonary nodules.
- Conditions
- Pulmonary Function Assessment, Disease Free Survival, NSCLC, Stage I
- Trial name
- NCT06404164
- Testing
- Wedge resection under watershed analysis method
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Lung Cancer (Diagnosis), Fragmentomics
Noninvasive Detection of Lung Nodule Malignancy Using cfDNA Fragmentomics
The goal of this observational study is to learn if cfDNA fragmentomics can noninvasively diagnose whether lung nodules are benign or malignant in adults with imaging-detected lung nodules.
- Trial name
- SHC2408 (NCT07399210)
- Testing
- This study did not include intervention between two cohorts
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Baohui Han
Pulmonary Nodule Cm
Bronchoscopy Assisted by Electromagnetic Navigation (EMN) in the Diagnosis of Small Pulmonary Nodules
Due to CT screening, a lot of peripheral nodule not accessible to conventional endoscopy will be found. Electromagnetic navigation directed bronchoscopy (ENB) is a new technique needing validation.
- Trial name
- NCT01779388
- Testing
- Bronchoscopy
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- European Lung Cancer Working Party
Non-small Cell Lung Cancer, Pulmonary Nodule, Multiple
Breath Combined With CT for Diagnoses of Pulmonary Nodules
Pulmonary nodules diagnosis using breath test of volatile organic compound (VOC) is in its infancy. The accuracy of VOC analysis in diagnosing malignant pulmonary nodules varies cross the published studies.
- Trial name
- NCT04948047
- Testing
- Pathological examinations as the golden diagnosis criteria, Breath test combined with computed tomography
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Peking University People's Hospital
Pulmonary Nodule, Solitary, Lung Cancer
3D Printing for Nodule Localization
Implementation of lung cancer screening using low-dose computed tomography has increased the rate of detection of small peripheral pulmonary nodules.
- Trial name
- NCT04056923
- Testing
- 3D-printing guided, CT-guided, Indocyanine Green
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Wen-zhao ZHONG
Non Small Cell Lung Cancer, Non Small Cell Lung Cancer (NSCLC)
Liquid Biopsy Assay of EBUS-TBNA Supernatant Fluid for Diagnosing Lung Cancer
Background and aim: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the gold standard of lung cancer staging, yet up to 15% of procedures produce inadequate samples for definite diagnosis or…
- Conditions
- Non Small Cell Lung Cancer, Non Small Cell Lung Cancer (NSCLC), Lung Cancer (NSCLC), Lung Cancer - Non Small Cell
- Trial name
- NCT06889467
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Barzilai Medical Center
Lung Nodules, Ultrasound
Ultrahigh-frequency Ultrasonography (UHFUS) in Detection of Small Pulmonary Ground Glass Opacity (GGO)
The purpose of this study is to assess the feasibility of UHFUS on detection of GGOs in excised lung tissue and investigate UHFUS features of GGO in vitro. Each GGO was detected by palpation, UHFUS and open biopsy in sequence.
- Conditions
- Lung Nodules, Ultrasound, Detection Rate
- Trial name
- UHFUSGGO (NCT05994898)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Non Small-cell Lung Cancer
Liquid Biopsy for Early Non-small Lung Cancer Detection
This clinical trial will assess the performance of a liquid biopsy assay to identify cancer in indeterminant pulmonary nodules identified by CT screening of high-risk individuals and evaluate the capability of the liquid biopsy…
- Trial name
- NCT05462795
- Testing
- Liquid biopsy for aberrant DNA methylation analysis - Indeterminate pulmonary nodule, Liquid biopsy for aberrant DNA methylation analysis - Known lung cancer for surgical resection, Liquid biopsy for aberrant DNA methylation analysis - Healthy volunteer
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Advanced Colorectal Cancer, Circulating Tumor DNA
Circulating Tumor DNA Guided Therapeutic Strategies for CRC Patients With Small Pulmonary Nodules
The clinical diagnosis and treatment of small pulmonary nodules (suspected to be lung metastases) in advanced colorectal cancer patients remain controversy.
- Trial name
- NCT05495672
- Testing
- Local treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Junjie Peng
Suture, Nodule, Solitary Pulmonary
Semi-barbed Suture for Pulmonary Small Nodules Localization
Hookwire and microcoil are currently the most widely used localization instruments. Although their success rate is relatively high in preoperative localization attempts, they may lead to consequences that negatively affect…
- Conditions
- Suture, Nodule, Solitary Pulmonary, Video-Assisted Thoracoscopic Surgery
- Trial name
- NCT04168359
- Testing
- absorbable semi-barbed suture
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Aerospace General Hospital
Pulmonary Nodule, CT Guided Biopsy
Puncture Template Assisted Biopsy for Pulmonary Nodules
Pulmonary nodules are small in size and easy to move with breathing. CT guided puncture is highly dependent on the personal experience of physicians, that is, the accuracy, efficiency and incidence of complications of puncture…
- Trial name
- NCT04890301
- Testing
- CT guided biopsy for pulmonary nodule
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Peking University Third Hospital
Non-small Cell Lung Cancer, Early-stage Lung Cancer
Septum-guided Segmentectomy for Deep Early-stage Lung Cancer (SGS2512)
The purpose of this study is to evaluate the safety and effectiveness of a specialized surgical technique called "Septum-guided Segmentectomy" for treating early-stage lung cancer located deep within the lung tissue.Standard…
- Conditions
- Non-small Cell Lung Cancer, Early-stage Lung Cancer, Deep-seated Lung Nodules, Solid-dominant Lung Cancer
- Trial name
- SGS2512 (NCT07564557)
- Testing
- Septum-guided Segmentectomy
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Shanghai Chest Hospital
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Lung Cancer
Intra-op vs Pre-op Transbronchial Localization for Small Lung Nodule
Comparing pre-operative transbronchial localization under augmented fluoroscopy and intra-operative transbronchial localization using electromagnetic navigation bronchoscopy system for small lung nodules.
- Trial name
- NCT03793387
- Testing
- AF-guided endobronchial marking, ENB-guided endobronchial marking
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch