Clinical trials: Smell
Alzheimer s Disease, Mild Cognitive Impairment (MCI)
Crownlands Observing Progression With Neurons Study
The CROWN-I Study is an observational study to learn about molecular features of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
- Trial name
- CROWN-I (NCT07611396)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Crownlands
Anosmia, COVID-19
Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19
Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19), accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic olfactory dysfunction (COD,) lasting more than 6…
- Trial name
- NCT05226546
- Testing
- Platelet rich plasma (PRP), olfactory training
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Infectious Disease
Perception of Smell and Taste During Antibiotic Treatment
Antibiotic use may be associated with effects on the perception of smell and taste. These effects are poorly known. The mechanisms can be very diverse, and the effect can be very variable depending on the type of antibiotic used…
- Trial name
- OGUSTA (NCT03893279)
- Testing
- Smell and Taste and questionnaire
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Hospices Civils de Lyon
Covid19, Taste Disorder, Secondary
Lactoferrin for COVID-19-Induced Taste or Smell Abnormality
Common side effects of corona virus disease 2019 (COVID-19) include disruptions in taste and smell function, which may persist for prolonged periods of time following recovery and resolution of COVID-19 infection.
- Conditions
- Covid19, Taste Disorder, Secondary, Taste Disorders, Dysgeusia
- Trial name
- TSA (NCT05760079)
- Testing
- Lactoferrin
- Sponsor
- Wake Forest University Health Sciences
Head and Neck Cancer, Mucositis Oral
GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer
GM-CSF may protect normal cells from the side effects, such as mucositis, of radiation therapy and may help damaged tissue heal faster after radiation therapy.
- Conditions
- Head and Neck Cancer, Mucositis Oral, Radiation Toxicity, Tongue Cancer
- Trial name
- NCT00293462
- Testing
- sargramostim, oral salt and soda mouthwash
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Marilyn Dodd
Neoplasms, Malnutrition
Oral Nutritional Supplement Preferences in Patients With Cancer
Patients diagnosed with cancer have a particularly high risk of developing malnutrition due to the disease itself and due to symptoms of cancer treatments that can affect food intake such as reduced appetite, nausea, fatigue, and…
- Trial name
- NCT05816369
- Testing
- Taste session of five ONS flavors
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University of Bergen
Parkinson Disease, Olfactory Disorder
The Efficacy of Olfactory Training Intervention on Olfactory and Other Non-motor Symptoms in PD
To explore the efficacy of olfactory training on olfactory and other non-motor symptoms in PD.
- Conditions
- Parkinson Disease, Olfactory Disorder, Olfactory Training
- Trial name
- NCT06607653
- Testing
- Olfactory training
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Parkinson Disease
Early Longitudinal Imaging in Parkinson's Progression Markers Initiative Using [¹⁸F] AV-133 and DaTscan™
Directly examine whether early (6-month) imaging with DaTscan and [¹⁸F] AV-133 will provide an early signal of disease progression in recently diagnosed untreated PD patients.
- Trial name
- NCT04507139
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Anesthesia; Adverse Effect
Neurotoxicity of Anesthesia in Middle Aged Patients
for the last 20 years, the increasing reports from non-human studies have raised suspicion that general anesthetics may cause neurotoxic changes in the developing brain that lead to adverse neurodevelopmental outcomes later in…
- Trial name
- NCT04275531
- Testing
- Anesthesia Agent
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Tanta University
Perioperative Neurocognitive Disorder
Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear.
- Trial name
- NCT06488807
- Testing
- Olfactory Enrichment
- Where
- China
- Volunteers
- 686 people
- Sponsor
- Shanghai 10th People's Hospital
Chronic Rhinosinusitis (CRS)
Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS
The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT06834477
- Testing
- Computed Tomography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anosmia, Hyposmia
The Clinical Applicability of the 'TIB' Olfactory Test Device
The aim of this study was to evaluate the validity and test-retest reliability of the 'TIB' Olfactory Test Device, a new olfactory test tool developed by Top International Biotech, Taipei, and to determine its normative values.
- Trial name
- NCT05152030
- Testing
- 'TIB' Olfactory Test, Traditional Chinese version of the University of Pennsylvania of Smell Identification Test (UPSIT-TC)
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Rhinosinusitis
Olfactory Dysfunction of Rhinosinusitis
The purpose of this research is to improve understanding of the molecular and functional properties of the human olfactory system.
- Trial name
- ODOR (NCT00797004)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Greg Davis
Weight, Birth, Premature Birth
Effects of Olfactory and Gustatory Stimulus on the Nutrition of Premature Babies
The objective of this clinical trial is to test the effects of olfactory and taste stimulation with milk or water in premature newborns with a gestational age between 28 and 32 weeks.
- Trial name
- NCT06305052
- Testing
- Milk, Water
- Where
- Brazil
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
COVID-19, Olfactory Disorder
Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia
This study will investigate the efficacy of oral fluvoxamine in olfactory improvement following Covid-19- associated parosmia. This is a randomized, double-blinded, placebo-controlled trial.
- Conditions
- COVID-19, Olfactory Disorder, Parosmia
- Trial name
- FluCOP (NCT05216614)
- Testing
- Fluvoxamine
- Where
- United States
- Sponsor
- Washington University School of Medicine
Hyposmia
Study of CYR-064 Versus Placebo in Patients.
Randomized, double-blinded, placebo-controlled trial to determine the safety and efficacy of CYR-064.
- Trial name
- NCT06019000
- Testing
- CYR-064
- Where
- 14 sites in United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Cyrano Therapeutics, Inc.
Nasal Obstruction
Nasal Obstruction and Olfactory Losses
About 13% of US adults, some 30 million people, suffer from nasal sinus disease. Although nasal obstruction and smell loss are two of the major symptoms of the disease that are crucial to disease management, currently there is a…
- Trial name
- NCT05920330
- Testing
- Nasal Plug
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Respiratory Distress
The Smell of Breast Milk and Therapeutic Positions in Comfort
Before starting the data collection process, a pilot study was conducted with 10 preterm newborns, five in the safe swaddling group and five in the control group, to evaluate the comprehensibility of the questionnaire form and…
- Trial name
- NCT06826053
- Testing
- Therapeutic position, Therapeutic position + smell breast milk
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Karamanoğlu Mehmetbey University
Olfaction Disorders
Study of EEG and Nasal Stimulus in Olfactory Disorders
Neuroscent aims to analyze EEG signals induced by olfactory stimuli in individuals with normal and impaired olfactory functions, with a focus on patients with tinnitus.
- Trial name
- SENSO (NCT06589375)
- Testing
- Sniffin'Sticks
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Anosmia, Covid19
COVID-19 in Patients With Anosmia in Egypt
The study aims to test the frequency of severe acute respiratory syndrome new corona virus SARS-CoV-2 or other respiratory viruses in patients presenting with anosmia or dysgeusia to Ain Shams University Hospitals, Cairo, Egypt.
- Conditions
- Anosmia, Covid19, Dysgeusia
- Trial name
- NCT04473157
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Ain Shams University