Clinical trials: Smell Disorders
Healthy
Physiological Effects of Androstadienone Exposure
The reason for doing this research is to understand why different people show different responses when they smell an odor called androstadienone. Androstadienone is a chemical found in male sweat.
- Trial name
- NCT00553384
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Spinal Cord Injury
Collection and Characterisation of Human Olfactory Ensheathing Cells
We aim to retrieve olfactory bulbs (OBs) from suitable human donors. We have defined two groups who will qualify: Group 1 - Deceased Donors: 1A: Donors after brainstem death (DBDs) undergoing solid organ donation 1B: Donors after…
- Trial name
- NCT02870426
- Testing
- Frontal Craniotomy and retrieval of OBs, OB Retrieval During Anterior Cranial Surgery
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's, University of London
Hyposmia, COVID-19
Olfactory Training as a Treatment for Olfactory Dysfunction Post COVID-19
Olfactory dysfunction is a defining symptom of COVID-19 infection. Studies have demonstrated improved olfaction in patients with post infectious olfactory dysfunction after an olfactory training (OT).
- Conditions
- Hyposmia, COVID-19, Parosmia, Anosmia
- Trial name
- OTTODC19 (NCT05384561)
- Testing
- Smell training
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Université du Québec à Trois-Rivières
Sleep Deprivation
Olfactory Decision-making and Deprived Sleep
This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.
- Trial name
- ODDS (NCT05093413)
- Testing
- Sleep deprivation
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cancer
Capecitabine Combined With Cisplatin in Treating Patients With Locally Advanced or Metastatic Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one chemotherapy drug may kill more tumor cells.
- Trial name
- NCT00010023
- Testing
- capecitabine, cisplatin
- Where
- United States
- Sponsor
- NYU Langone Health
Patients Without an Olfactory Disorder
Standardization of a New Psychophysical Olfactory Test, TODA2
Recruitment of patients consulting the IUFC for another pathology unrelated to an olfactory disorder: Interview and clinical examination and Passing the 2 olfactory tests for 30 voluntary's patients, a second consultation of 15…
- Trial name
- TODA-STAR (NCT06386523)
- Testing
- Passage of olfactory tests
- Where
- 2 sites in France
- Volunteers
- 112 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Alzheimer Disease
Olfactory Neuroepithelial Tissue of Alzheimer Disease
The purpose of this study is to evaluate the olfactory neuroepithelium as a biomarker of Alzheimer disease. The early diagnosis of Alzheimer disease is of importance for obtaining better response to treatment, but recently…
- Trial name
- NCT02129452
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Allergic Rhinitis, Rhinosinusitis Chronic
Treatment of Allergic Rhinitis and Chronic Polypous Rhinosinusitis With Olfactory Mucosa-derived Mesenchymal Stem Cells
Treatment of patients with allergic rhinitis and chronic polypous rhinosinusitis with olfactory mucosa-derived mesenchymal stem cells
- Trial name
- NCT05167552
- Testing
- Olfactory mucosa-derived mesenchymal stem cells, Standard treatment of type Allergic Rhinitis according to the clinical protocols, Standard treatment of type Chronic Polypous Rhinosinusitis according to the clinical protocols
- Volunteers
- 60 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Olfactory Disorder, Olfaction Disorders
Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction
This randomized clinical trial will evaluate the benefit of platelet-rich plasma (PrP) in the treatment of olfactory dysfunction.
- Conditions
- Olfactory Disorder, Olfaction Disorders, Olfactory Nerve Injuries, Olfactory Nerve Disorder
- Trial name
- NCT04406584
- Testing
- Injection into olfactory cleft
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Smell Dysfunction, Olfactory Disorder
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss.
- Conditions
- Smell Dysfunction, Olfactory Disorder, Long COVID
- Trial name
- NCT05855369
- Testing
- Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Medical University of South Carolina
Smell Dysfunction
Effects of Isotretinoin on Smell
Isotretinoin is a common medicine used to treat moderate to severe acne. It often causes dryness of the skin and the inside of the nose.
- Trial name
- NCT07309341
- Testing
- isotretinoin
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Uşak University
Hyposmia
Treatment of Postviral Olfactory Dysfunction
A decreased sense of smell (hyposmia) is often caused by viral infections, such as COVID-19. Today, the only recommended treatment for hyposmia is olfactory training, a time consuming method with limitations in terms of both…
- Trial name
- NCT06142565
- Testing
- Nose plug, Regular olfactory training
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Karolinska Institutet
Infarction, Middle Cerebral Artery, Ischemic Stroke,
Implantation of Olfactory Ensheathing Cells (OECs)
Recruited patients should receive the endoscopic surgery for picking the olfactory mucosa 1 to 2 months before transplantation. The Olfactory Ensheathing Cells (OECs) will be cultured and expanded under the rule of GTP.
- Conditions
- Infarction, Middle Cerebral Artery, Ischemic Stroke,, Stroke With Hemiparesis,, Thromboembolic Stroke.
- Trial name
- OECs (NCT01327768)
- Testing
- Olfactory ensheathing cells
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- China Medical University Hospital
Post COVID-19, Cognitive Dysfunction
Multimodal Investigation of Post COVID-19 in Females
The purpose of this study is to investigate the effects of transcutaneous vagus nerve stimulation (t-VNS) on Long Covid symptoms in females and to identify factors influencing susceptibility and recovery-particularly in the…
- Trial name
- NCT05225220
- Testing
- Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Bladder Cancer, Breast Cancer
Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer
RATIONALE: Physician-initiated smoking cessation strategies may be effective in getting early-stage cancer patients to quit smoking.
- Conditions
- Bladder Cancer, Breast Cancer, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00002520
- Testing
- nicotine, Usual Care
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- Eastern Cooperative Oncology Group
Breast Cancer, Colorectal Cancer
Family Quality of Life Among Families With a Member Who is a Cancer Patient
RATIONALE: Developing a questionnaire that can be used to assess the quality of life among people who have a family member with cancer may help the study of cancer in the future.
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00544336
- Testing
- questionnaire administration, survey administration, quality-of-life assessment
- Where
- 3 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Nasal Polyposis
Smell Exploration in Patients With Nasal Polyposis : Study by Functional Magnetic Resonance Imaging
Nasal polyposis (NP) is a disease affecting 4% of the population. This disease is frequently accompanied by olfactory disorders (41%-84% of patients) that affect patients' quality of life.
- Trial name
- ODORAT_IRMf (NCT03979716)
- Testing
- fMRI
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Anosmia
Value of Platelet-Rich Plasma in Post Severe Acute Respiratory Syndrome Coronavirus 2
The study will be conducted to evaluate : The efficacy of Platelet Rich plasma in treatment of smell disorders post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via the growth factors involved in accelerating and…
- Trial name
- NCT05395845
- Testing
- platelets rich plasma
- Volunteers
- 88 people
- Sponsor
- Aya abdelnasser hassani
Parkinson Disease
Role of Nasal Dysbiosis in Parkinson Disease
Olfactory dysfunction is frequent in Parkinson Disease (PD) and may be present years before the motor symptoms appear. The early olfactory dysfunction could result from environmental factors acting through the nasal cavity such…
- Trial name
- SMELLPARK (NCT04249245)
- Testing
- Nasal Swab
- Where
- 2 sites in France, Guadeloupe
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Cystic Fibrosis With Other Manifestations, Sinusitis
Longitudinal Pathogen-colonization in Cystic Fibrosis Airways and Ability to Smell
Aim of the study is to detect the prevalence of chronic rhinosinusitis, pathogen colonization of the lower and upper airways and, in a sub-cohort the sense of smelling in patients with cystic fibrosis.
- Trial name
- NCT00803881
- Testing
- nasal lavage and sputum collection
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University of Jena