Clinical trials: Smell Dysfunction, open to volunteers
Subjective Cognitive Decline (SCD), Olfactory Dysfunction
The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can delay the progression of MCI in older…
- Conditions
- Subjective Cognitive Decline (SCD), Olfactory Dysfunction, Mild Cognitive Impairment (MCI), ELDERLY PEOPLE
- Trial name
- NCT06821828
- Testing
- Modified olfactory training device, Conventional olfactory training device
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Olfactory Dysfunction, Smell Loss
Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults
The goal of this clinical trial is to learn if ScentCare, a novel olfactory training device and accompanying companion web-based application, will lead to improved olfactory and well-being outcomes in elderly patients with…
- Conditions
- Olfactory Dysfunction, Smell Loss, Anosmia, Hyposmia
- Trial name
- SPLENDOR-OA (NCT06733636)
- Testing
- Sudoku Puzzles, ScentCare (Olfactory Training Device)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Olfactory Dysfunction, Wellbeing
Impact of Smell Testing on Health Outcomes
Smell dysfunction is frequent yet neglected. The sense of smell plays a crucial role in signaling disease, safety, and overall quality of life.
- Trial name
- NCT07222891
- Testing
- Patient-centered information and education
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Endonasal Surgery, Endoscopic Sinus Surgery
In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy
This research is being done to better characterize the part of the nose that helps people smell. Currently, the only ways to study smell loss mostly rely on how people report it, rather than being able to see the underlying…
- Conditions
- Endonasal Surgery, Endoscopic Sinus Surgery, Olfactory Dysfunction
- Trial name
- NCT07546617
- Testing
- CONVIVO system, Fluorescein injection, USP 10%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Olfaction Disorders, Smell Disorders
Olfactory Training on Smell Dysfunction Patients in HK
Causes of olfactory dysfunction can be classified into conductive and sensorineural causes. Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery Sensorineural causes included…
- Conditions
- Olfaction Disorders, Smell Disorders, Anosmia, Hyposmia
- Trial name
- NCT05364125
- Testing
- Olfactory Training, Control
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Pamela Youde Nethersole Eastern Hospital
Olfactory Dysfunction, Post Viral Olfactory Dysfunction (PVOD)
The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is the modified olfactory training device effective in treating patients with…
- Trial name
- NCT06829706
- Testing
- Conventional olfactory training device, Modified olfactory training device
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Alzheimer s Disease, Mild Cognitive Impairment (MCI)
Crownlands Observing Progression With Neurons Study
The CROWN-I Study is an observational study to learn about molecular features of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
- Trial name
- CROWN-I (NCT07611396)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Crownlands
Smell Dysfunction
The Effectiveness of Steroid Nasal Drops in the Olfactory Cleft Combined With Olfactory Training for Patients With PIOD
This study aims to evaluate the effectiveness of hormone nasal drops in the olfactory cleft combined with olfactory training for treating postinfectious olfactory dysfunction (PIOD).
- Trial name
- PIOD (NCT07386860)
- Testing
- Steroid nasal drops combined with olfactory training
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Smell Dysfunction, Olfactory Disorder
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss.
- Conditions
- Smell Dysfunction, Olfactory Disorder, Long COVID
- Trial name
- NCT05855369
- Testing
- Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Medical University of South Carolina
Chronic Rhinosinusitis (CRS), Olfactory Dysfunction
Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory Dysfunction
This single-center randomized controlled trial evaluates whether budesonide nasal drops delivered in the Wu's position (Wu's 45° Head-Hanging Reclination Position) improve olfactory function more effectively than conventional…
- Trial name
- NCT07386873
- Testing
- Nasal Drops, Nasal Spray
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Peking University Third Hospital
Smell Loss, Chronic Rhinosinusitis (CRS)
Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss.
- Trial name
- CIPOD (NCT07681973)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Outcome
Factors Influencing the Prognosis of Olfactory Dysfunction After Upper Sensation
Objective: This study aimed to analyze the outcomes of post-infectious olfactory dysfunction treated with different doses of corticosteroids and specify factors related to the curative effect.
- Trial name
- NCT04918953
- Testing
- methylprednisolone, budesonide atomization suspension
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Olfactory Dysfunction, Chronic Rhinosinusitis
The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can treat postoperative olfactory dysfunction in…
- Trial name
- NCT06837051
- Testing
- Conventional olfactory training device, Modified olfactory training device, Budesonide irrigation
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Peking University Third Hospital
Chronic Rhinosinusitis (CRS)
Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS
The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT06834477
- Testing
- Computed Tomography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital