Clinical trials: Smokeless Tobacco
Smokeless Tobacco Use
An Internet-Based Smokeless Tobacco Cessation Program for Teens
To compare the efficacy of a targeted, tailored, and highly interactive smokeless tobacco cessation website to a website with more static information that is similar to websites that can be found through a typical Internet search.
- Trial name
- NCT00680615
- Testing
- Tailored, enhanced condition, Usual Care
- Where
- United States
- Volunteers
- 1,716 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Tobacco Use Disorder
Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use
Though spit tobacco is smokeless, it still affects the cardiovascular system and may be associated with heart disease, stroke, and high blood pressure.
- Trial name
- Brandswitch (NCT00218244)
- Testing
- Lower Nicotine Smokeless Tobacco Product, Behavioral Counseling
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Smoking Cessation
Preventing Relapse Following Involuntary Smoking Abstinence
The prevalence of tobacco use in the military is too high. This study is designed to take advantage of the 8.5 weeks of forced tobacco cessation during Basic Military Training and develop effective interventions to prevent…
- Trial name
- AFV (NCT01374724)
- Testing
- Tobacco Use Ban, Tailored Pamphlet, Informational Pamphlet
- Where
- 2 sites in United States
- Volunteers
- 23,000 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Smoking Cessation, Smokeless Tobacco
In-vivo Extraction of Pb, Cd andTSNA From Swedish Snus
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Conditions
- Smoking Cessation, Smokeless Tobacco, Harm Reduction
- Trial name
- SMWS03 (NCT01249339)
- Testing
- Buccal Administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Smokeless Tobacco Cessation
Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation
This research study will determine if using a combination of 4-mg nicotine lozenges, self-help materials, and/or telephone tobacco cessation counseling will help smokeless tobacco users stop using tobacco.
- Trial name
- LASH (NCT01341938)
- Testing
- Commit® nicotine lozenges (4 mg) & self-help materials, Commit® nicotine lozenges (4 mg) & phone counseling & self-help materials, Phone counseling & self-help materials
- Where
- United States
- Volunteers
- 1,067 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Nicotine Dependence
Health Effects of SLT, Cigarette Smoking, and New Tobacco Products
The use of smokeless tobacco (ST) as a substitute for cigarette smoking has been suggested since it is considered by some to be a less harmful tobacco product (Russell, Jarvis and Feyerabend, 1980; Russell et al, 1981; Rodu…
- Trial name
- ANTS3 (NCT00469079)
- Testing
- Nicotine gum and lozenge, Taboka, Camel Snus
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smokeless Tobacco, Tobacco Use Cessation
Telephone Counseling for Snuff Users
The primary objective is to evaluate the effectiveness of telephone-based counseling in promoting smokeless tobacco cessation among residents of Minnesota.
- Trial name
- NCT00265681
- Testing
- Phone counseling and written materials
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- HealthPartners Institute
Smokeless Tobacco Use
A Pilot Study Evaluating Nicotine Lozenges and Self Help
The investigators are hypothesizing that by offering both self-help materials and mailed nicotine lozenges we will be able to help increase tobacco abstinence rates among ST users, as well as decrease tobacco withdrawal.
- Trial name
- NCT00888459
- Testing
- nicotine replacement therapy
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking Cessation, Smokeless Tobacco
In-vivo Extraction of Pb, Cd and TSNA From Swedish Snus
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Conditions
- Smoking Cessation, Smokeless Tobacco, Harm Reduction
- Trial name
- SMWS03 (NCT01369693)
- Testing
- Buccal administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Tobacco Use Disorder
Nicotine Lozenge to Reduce Smokeless Tobacco Use
Smokeless tobacco (ST), which includes both chewing tobacco and snuff, has as many health risks associated with its use as cigarettes.
- Trial name
- NCT00218283
- Testing
- Nicotine Lozenge, Behavioral Counseling
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Cessation, Tobacco Use Disorder
Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid
Coal miners in Central Appalachia have among the highest rates of tobacco and nicotine product (TNP) use of any occupational group and face elevated rates of lung cancer and coal workers' pneumoconiosis ("black lung").
- Conditions
- Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
- Trial name
- NCT07694492
- Testing
- QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Smokeless Tobacco Cessation
Addressing Tobacco Use Disparities Through an Innovative Mobile Phone Intervention
The purpose of this study is to evaluate the feasibility, acceptability and preliminary efficacy of a Scheduled Gradual Reduction (SGR) intervention via Short Message Service (SMS) text messaging plus SMS Support Messages in…
- Trial name
- NCT02613689
- Testing
- Scheduled Gradual Reduction (SGR), Text Messages
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Cigarette Smoking
Development of Biomarkers of Effect From Chronic Tobacco Usage
This study was conducted to develop biomarkers of tobacco effect that would indicate potential harm related to tobacco consumption.
- Trial name
- NCT01923402
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Tobacco Company
Tobacco Cessation
A Web-Based Text Messaging for Tobacco Cessation in Rural Mississippi
Cigarette smoking prevalence has decreased to ~12% in 2022; however, over 40 million U.S. adults were current cigarette smokers in the same year.
- Trial name
- NCT07431619
- Testing
- Motivational text messaging for tobacco cessation, Non-specific text messaging
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Smokeless Tobacco
Influence of Authorized Smokeless Tobacco Product Modified Risk Claims II: Laboratory Assessment of Sensory and Subjective Effects
This study seeks to measure the effects of smokeless tobacco product risk messages on sensory experiences and future intentions to use.
- Trial name
- NCT07107139
- Testing
- Copenhagen group, Snus group
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Cardiovascular Disease, Cigarette Smoking
Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers
This cross-sectional study was primarily a cardiovascular disease (CVD) study designed a) to compare selected CVD biomarker data between subjects who were long-term consumers of cigarettes or moist snuff and non-consumers of…
- Trial name
- NCT01692353
- Testing
- Subject's usual brand (UB) tobacco product
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Tobacco Company
Tobacco Use Disorder
Efficacy of Varenicline for Smokeless Tobacco Use in India
This study, based in India, is testing the efficacy of varenicline to help smokeless tobacco users with cessation efforts.
- Trial name
- NCT01098305
- Testing
- Varenicline, Counseling
- Where
- India
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder, Smoking
A Pilot Study to Evaluate the Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge
This is a study to determine the safety and effectiveness of silver salt in Ariva® Silver Wintergreen Lozenge on discouraging smoking, by its imparting an unfavorable taste to the smoker when tobacco is smoked.
- Trial name
- NCT01336816
- Testing
- Ariva Silver Wintergreen
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Star Scientific, Inc
Urine Detectable Acute and Chronic Diseases
A Comparative, Controlled Study to Evaluate the Lay User Accuracy and Performance of the Dip Home-Based Dipstick Analyzer
The Dip Home-Based Dipstick Analyzer (henceforth HBDA) is composed of a kit and a smartphone application. The device will be provided to the subject in a simulated home-use environment.
- Trial name
- NCT04466774
- Testing
- Dip Home-Based Dipstick Analyzer, Urine analysis predicate device for professional user
- Where
- 3 sites in United States
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- Healthy.io Ltd.
Tobacco Dependence
Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
Smokeless tobacco (ST) is a known human carcinogen. Long-term ST use is known to increase the risk for oropharyngeal cancer. Extant literature on cigarette smokers suggests that smoking reduction increases smoking abstinence…
- Trial name
- NCT01018394
- Testing
- nicotine lozenges, tobacco-free snuff
- Where
- 2 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic