Clinical trials: Smokeless Tobacco
Smokeless Tobacco Cessation
Improvement in Knowledge and Perception About Hazards of Smokeless Tobacco
Oral cancer is a serious and growing problem in many parts of the globe. Oral cancer is the eighth most common cancer worldwide.The annual estimated incidence is around 275,000 for oral and 130,300 for pharyngeal cancers…
- Trial name
- NCT03418506
- Testing
- SMOKELESS TOBACCO AWARENESS PROGRAM
- Where
- Pakistan
- Volunteers
- 1,327 people
- Sponsor
- Aga Khan University
Tobacco Use Cessation
A Multi-Media Approach to Partner Support in Smokeless Tobacco Cessation (UCare-ChewFree)
In an earlier study, the investigators developed a guidebook that taught women supportive behaviors to help their husbands/partners quit smokeless tobacco.
- Trial name
- NCT01885221
- Testing
- Multimedia Support Intervention
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
DENTAL CARIES
Incidence of Caries in Smoking and Smokeless Tobacco
The following observational study evaluates incidence of caries in smoking and smokeless tobacco based on habit history by clinical examination and DMFT index.
- Trial name
- ICSSLT (NCT02767050)
- Where
- India
- Volunteers
- 613 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Tobacco Use
CSD190103: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products
The purpose of this study is to compare plasma nicotine uptake in adult snus consumers after using investigational snus products (A19010-W and B19010-F).
- Trial name
- NCT03993795
- Testing
- A19010-W, B19010-F
- Where
- 6 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smokeless Tobacco Use
Highdose Nicotine Patch Therapy for Smokeless Tobacco Use
Smokeless tobacco use ("chewing") is associated with negative health effects. To date, no medications have been shown to help chewers quit long-term.
- Trial name
- NCT00939029
- Testing
- nicotine replacement therapy (nicotine patches)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
T2D
Adding Acetazolamide on Top of SGLT2 Inhibition in Persons With Type 2 Diabetes
The study aims to determine the acute efficacy and safety of three sequential doses of acetazolamide (62.5 mg, 125 mg, 250 mg) each for 2 weeks in 20 patients with T2D receiving background SGLT2i therapy.
- Trial name
- DIPPER Pilot (NCT07902726)
- Testing
- Acetazolamide 62.5 mg, Acetazolamide 125 mg, Acetazolamide 250 mg
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Tobacco Use
CSD190101: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products
The purpose of this study is to compare plasma nicotine uptake in adult snus consumers after using investigational snus products (A19010-F and B19010-F).
- Trial name
- NCT03993769
- Testing
- A19010-F, B19010-F
- Where
- 6 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Stereotyped Behavior, Tobacco Smoking Behavior
"EASY EFFECTIVE SMOKELESS" With NICORETTE®
The actually most accepted method of effective smoking cessation is based on structured consultation and medical care in combination with supportive medical treatment.
- Trial name
- NCT01323491
- Testing
- Nicotine replacement therapy
- Where
- Germany
- Volunteers
- 184 people
- Sponsor
- Johnson & Johnson GmbH
Eye Manifestations, Tobacco; Use, Harmful
Effect of Smokeless Tobacco on Anterior Segment
Observational, comparative, cross-sectional study
- Conditions
- Eye Manifestations, Tobacco; Use, Harmful, Tobacco Chewing Toxicity
- Trial name
- NCT04776863
- Testing
- optical biometry measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 107 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Pre-Gestational Diabetes, Type2diabetes
A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE
DIP : To conduct a pragmatic, non-blinded randomized controlled trial (pRCT) of immediate in-patient postpartum OGTT prior to delivery discharge (intervention) versus 4-12 week outpatient postpartum OGTT (current standard care)…
- Conditions
- Pre-Gestational Diabetes, Type2diabetes, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT05909046
- Testing
- Immediate inpatient postpartum OGTT, Standard of care 4-12 week postpartum OGTT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Ohio State University
Tobacco Use Disorder
Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use
Though spit tobacco is smokeless, it still affects the cardiovascular system and may be associated with heart disease, stroke, and high blood pressure.
- Trial name
- Brandswitch (NCT00218244)
- Testing
- Lower Nicotine Smokeless Tobacco Product, Behavioral Counseling
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smokeless Tobacco, Nicotine Dependence
Treating Smokeless Tobacco Use in Rural Veterans
This is a pilot study designed in an effort to develop and improve access to effective treatments for tobacco use in rural Veterans using a tailored intervention approach.
- Trial name
- NCT02994082
- Testing
- Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Mark Vander Weg
Smokeless Tobacco Use, Tobacco Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 1
The extent of toxicity varies considerably across different brands of smokeless tobacco (ST) products and data suggest that greater toxicity may result in greater health risks.
- Trial name
- NCT01067586
- Where
- 3 sites in United States
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use Disorder, Smoking
A Pilot Study to Evaluate the Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge
This is a study to determine the safety and effectiveness of silver salt in Ariva® Silver Wintergreen Lozenge on discouraging smoking, by its imparting an unfavorable taste to the smoker when tobacco is smoked.
- Trial name
- NCT01336816
- Testing
- Ariva Silver Wintergreen
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Star Scientific, Inc
Smoking Cessation, Smokeless Tobacco
In-vivo Extraction of Pb, Cd andTSNA From Swedish Snus
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Conditions
- Smoking Cessation, Smokeless Tobacco, Harm Reduction
- Trial name
- SMWS03 (NCT01249339)
- Testing
- Buccal Administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Tobacco Use Disorder
Efficacy of Varenicline for Smokeless Tobacco Use in India
This study, based in India, is testing the efficacy of varenicline to help smokeless tobacco users with cessation efforts.
- Trial name
- NCT01098305
- Testing
- Varenicline, Counseling
- Where
- India
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoke Exposure, Smokeless Tobacco
Effect of Passive Smoking on Functional Capacity, Cognition and Academic Performance in Primary School Children
This is an observational study that aims to understand the effects of passive smoking (secondhand smoke exposure) on children's health and development.
- Trial name
- NCT06723470
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Egyptian Chinese University
Urine Detectable Acute and Chronic Diseases
Dip Home-Based Dipstick Analyzer Performance Evaluation
The Dip Home-Based Dipstick Analyzer (henceforth HBDA) is composed of a kit and a smartphone application. The device will be provided to the subject in a simulated home-use environment.
- Trial name
- NCT04465682
- Testing
- Experimental: Dip Home-Based Dipstick Analyzer
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Healthy.io Ltd.
Diplopia
A Predictive Score for the Ischemic Etiology of a Transient Diplopia (VASCO-DIP)
The transient diplopias (TD) is defined by a short diplopia. Their etiology may be ophthalmological, neurological non-ischemic or of ischemic origin.
- Trial name
- VASCO-DIP (NCT02576925)
- Testing
- Clinical, ophthalmological and neurological evaluation
- Where
- 2 sites in France
- Volunteers
- 220 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cardiovascular Disease, Cigarette Smoking
Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers
This cross-sectional study was primarily a cardiovascular disease (CVD) study designed a) to compare selected CVD biomarker data between subjects who were long-term consumers of cigarettes or moist snuff and non-consumers of…
- Trial name
- NCT01692353
- Testing
- Subject's usual brand (UB) tobacco product
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Tobacco Company