Clinical trials: Smokers
Healthy, Healthy Smoker
Inhaled RB042 in Healthy Adult Volunteers, Healthy Adult Smokers and Patients With Chronic Obstructive Pulmonary Disease
This is a 4-part, randomised, double-blind, placebo-controlled, first in human study evaluating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of inhaled RB042.
- Conditions
- Healthy, Healthy Smoker, COPD (Chronic Obstructive Pulmonary Disease), COPD
- Trial name
- NCT07285122
- Testing
- RB042
- Where
- Australia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Atisama Therapeutics
Cigarette Smokers
A Consumer Use Behavior Study to Measure the Puffing Topography of Heated Tobacco Products
This is a parallel design cohort consumer use study to measure the puffing topography of two HTP devices, with two variants of HTP consumables ("sticks"), collectively referred to as the study investigational products (Study IP)…
- Trial name
- NCT07677280
- Testing
- P2515910, P2512610
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
COPD, Healthy Smoker
SLP Model Development in the Diagnosis of COPD Patients
This is an observational, comparative, multicentre study to develop a model for the Thora3Di™ against standard practice in patients who are undergoing investigation for COPD.
- Trial name
- SLPCOPD (NCT04584801)
- Testing
- Structured Light Plethysmography
- Where
- 7 sites in United Kingdom
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
Healthy Non-smoker
Matrix on Fruit Constituent Bioavailability
Primary objective is to evaluate the influence of matrix on the bioavailability of key phytochemical constituents in fruits and their subsequent effect on chronic disease risk factors.
- Trial name
- FRT (NCT01908634)
- Testing
- Milk-based Strawberry Beverage without meal, Water-Based Strawberry Beverage without meal, Milk-based strawberry Beverage with meal
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Smokers, Never Smokers
Prefatory Study to Explore Changes in Nasal Mucociliary Clearance and to Standardize Nasal Scraping Procedure
This study intends to evaluate the nasal mucociliary clearance (NMC) by determining the value obtained for saccharin transit time (STT) test over the course of 12 hours following a single cigarette use in adult smokers, to…
- Trial name
- NCT03086707
- Testing
- Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Healthy Volunteers, Moderate to Heavy Smokers
Study to Evaluate the Food Effect of Single-dose Bioavailability of Pracinostat in Healthy Adult Subjects
Open label study of Pracinostat will be tested to assess the effect of food on the single-dose pharmacokinetics in healthy non-smoking and smoking adult subjects under fasted and fed conditions.
- Conditions
- Healthy Volunteers, Moderate to Heavy Smokers, Non-smokers
- Trial name
- HVFE (NCT02058784)
- Testing
- pracinostat
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
Healthy Volunteers, Non-smokers
Evaluate the Effects of Itraconazole and Ciprofloxacin on Single-Dose PK of Pracinostat in Healthy Nonsmoking Subjects
This study is designed as a 2-part, open-label study to assess the effect of pracinostat with itraconazole (part 1) and pracinostat with ciprofloxacin (part 2) on the bioavailability of pracinostat.
- Trial name
- NCT02118909
- Testing
- Pracinostat, Itraconazole, Ciprofloxacin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Helsinn Healthcare SA
Healthy Highly Dependant Smokers
Assessment of V0018 2.5 mg Effect on Craving
The purpose of this study is to evaluate the reduction of craving and its time course after administration of V0018 2.5 mg compared to placebo in healthy highly dependant smokers.
- Trial name
- NCT02357888
- Testing
- V0018
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Healthy Volunteer Smokers
A Single Dose Bioequivalence Study OfTwo Formulations Of Nicotine Lozenges
Open label, single dose, four-way crossover in healthy smokers. Each subject will be treated with a single dose or four study treatments in a randomized sequence.
- Trial name
- NCT00651352
- Testing
- 4 mg nicotine lozenge, 2 mg nicotine lozenge, 2 mg nicotine prototype
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Current Smokers
Trial With Bronchipret and Sinupret to Evaluate Acceleration of Mucociliary Clearance (MCC)
Proof of concept: Superiority of Bronchipret or Sinupret to placebo in respect to mucociliary clearance
- Trial name
- NCT01928901
- Testing
- administration of Sinupret, administration of Bronchipret
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bionorica SE
Healthy Smokers
Nicotine Patch - Bioequivalence Study
The purpose of this study is to evaluate the bioequivalence of a new transdermal nicotine patch to that of a reference formulation following repeated applications
- Trial name
- NCT02089308
- Testing
- Test treatment : V0116 transdermal patch, Reference treatment : Nicotine transdermal patch
- Where
- France
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Healthy Volunteer Smokers
Oral Tolerability Of Two Nicotine Dosage Forms
This study is to evaluate the oral tolerability of a nicotine prototype
- Trial name
- NCT00682461
- Testing
- Nicotine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Smokers
Nicotine Patch Bioequivalence Study
The purpose of this study is to compare the relative bioavailability of nicotine following single application of a new transdermal formulation to that of a reference formulation.
- Trial name
- NCT01658202
- Testing
- V0116 transdermal patch (Test treatment ), Nicotine transdermal patch (Reference Treatment )
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Healthy Smokers
Nicotine Patch - Multidose Bioequivalence Study
The purpose of this study is to compare the relative bioavailability of nicotine following repeated applications of a new transdermal formulation to that of a reference formulation. Up to day 7
- Trial name
- NCT01658215
- Testing
- V0116 transdermal patch (Test treatment ), Nicotine transdermal patch (Reference treatment )
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Healthy Smokers
Pilot Pharmacokinetic Study of New Nicotine Lozenge Formulations
The purpose of this study is to determine the pharmacokinetic profile of nicotine following a single oral administration of three new nicotine lozenge formulations (V0474) in comparison with two reference products.
- Trial name
- NCT01574898
- Testing
- V0474 - A mg, V0474 - B mg, V0474 - C mg
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Healthy Subjects, Smokers
4 mg Nicotine Polacrilex Gum and Swedish Portion Snus
Fifteen healthy smokers are given single doses of General Onyx 1 g portion snus and General White 1g portion snus, respectively, and one piece of Nicorette 4 mg chewing gum.
- Trial name
- SMWS06 (NCT01182129)
- Testing
- Nicotine
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB