Clinical trials: Smokers
Smoking
The Effect of Cycloserine on Smoking Behavior in Nicotine Dependent Smokers
A total of 20 subjects will participate in this four week, between groups, double-blind, placebo controlled study. Subjects will participate in two experimental sessions separated by approximately one week.
- Trial name
- NCT00633256
- Testing
- Cycloserine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Electronic Cigarette Use
Effects of Nicotine Salt Aerosol on Cigarette Smokers
This grant compares the effects of cigarette smoking, protonated nicotine ("salt") aerosol through an Electronic Nicotine Delivery System (ENDS), and unprotonated nicotine aerosol through an ENDS on nicotine delivery, nicotine…
- Trial name
- NCT03974152
- Testing
- Subox Mini C with Avail 18 mg nicotine salt (protonated), Subox Mini C with Avail 18 mg nicotine (unprotonated), Own brand cigarette
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Tobacco Use Disorder
Comparing Smoking Treatment Programs for Lighter Smokers - 1
The purpose of this study was to compare two different types of Food and Drug Administration (FDA) approved smoking cessation medications (nicotine patch or bupropion) used in conjunction with two levels of counseling.
- Trial name
- NCT00086411
- Testing
- nicotine transdermal system, bupropion, Medication Management
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation
A Text Messaging Program for Smokers in Primary Care
This study is a four arm pilot randomized controlled trial testing the effect of a 12 week text messaging intervention and a mailed nicotine medication intervention, alone and in combination to a control condition consisting of…
- Trial name
- GR2Q (NCT03174158)
- Testing
- Mailed nicotine replacement therapy, Text messaging, Brief advice
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Massachusetts General Hospital
Smoking Cessation
A Single Dose-escalation Study of Cytisine in Adult Smokers
The objectives of this study are: 1. To assess the tolerability and safety of cytisine as a single oral dose. 2. To define the Cmax levels associated to the occurrence of dose-limiting adverse events.
- Trial name
- NCT03848208
- Testing
- cytisine
- Where
- Portugal
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Achieve Life Sciences
Cigarette Smoking-Related Carcinoma
Effects of Filter Ventilation and Ventilation Information on Product Use Behaviors in Cigarette Smokers
This clinical trial collects data to see how filter ventilation and ventilation information affects product use behaviors in cigarette smokers.
- Trial name
- COMET 2 3 1 (NCT04744285)
- Testing
- Cigarette packaging, Data capture, Questionnaire administration
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Electronic Cigarettes
Assessment of Two New Electronic Cigarettes in Cigarette Smokers
The purpose of this study is to determine differences in nicotine delivery, user behavior, subjective effects, and physiological effects, when cigarette smokers use an two new electronic cigarette devices (JUUL and IQOS) relative…
- Trial name
- NCT03435562
- Testing
- JUUL electronic cigarette, IQOS electronic cigarette, Own Brand cigarette
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine Dependence, Other Tobacco Product, Bladder Cancer
Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers
This study will test feasibility, in smokers with lung, head \& neck, and bladder cancers, that examines the effect of e-cigarette substitution, on measures of smoking-related toxicity and medical outcomes.
- Conditions
- Nicotine Dependence, Other Tobacco Product, Bladder Cancer, Lung Cancer, Cancer of Head and Neck
- Trial name
- NCT02648178
- Testing
- HALO
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Electronic Nicotine Delivery System Flavors
Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers
This study aims to better understand how the availability of electronic nicotine delivery system (aka electronic cigarettes) flavors (e.g., menthol, tobacco) impacts tobacco use behaviors, toxicant exposure, and abuse liability…
- Trial name
- RVA Flavors (NCT05023096)
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Smoking, HIV Infections
Smoking Cessation Using Motivational Therapy and Varenicline
People that are infected with HIV appear to be especially susceptible to the adverse effects of cigarette smoking. The purpose of this study is to determine if quitting smoking by using a specialized smoking cessation treatment…
- Trial name
- NCT00701896
- Testing
- Varenicline tartrate, Nicotine Replacement Therapy, Biological Control
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Philip Diaz
Smoking Cessation
A Second Study of Cytisinicline for Smoking Cessation in Adult Smokers
This placebo-controlled Phase 3 study is being conducted at sites within the United States to evaluate 3 mg cytisinicline TID for treatment duration of 42 days/6 weeks and evaluate 3 mg cytisinicline TID for treatment duration of…
- Trial name
- ORCA-3 (NCT05206370)
- Testing
- Cytisinicline, Behavioral support
- Where
- 12 sites in United States
- Volunteers
- 792 people
- Sponsor
- Achieve Life Sciences
Lung Carcinoma
MUC1 Vaccine in Preventing Lung Cancer in Current and Former Smokers at High Risk for Lung Cancer
This pilot phase I trial studies the side effects and how well MUC1 peptide-Poly-ICLC vaccine works in preventing lung cancer in current and former smokers at high risk for lung cancer.
- Trial name
- NCT03300817
- Testing
- Laboratory Biomarker Analysis, MUC1 Peptide-Poly-ICLC Vaccine
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Marijuana Use
Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana
The purpose of this study is to determine if the subjective effects of marijuana will be decreased by low-doses (< 25 mg) of naltrexone and increased by high-doses (> 50 mg) of naltrexone.
- Trial name
- NCT00403117
- Testing
- Naltrexone 12 Mg+ Active Marijuana (3.27% THC), Naltrexone 25 Mg + Active Marijuana (3.27% THC), Naltrexone 50 Mg+ Active Marijuana (3.27% THC)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cardiovascular Disease, Oxidative Stress
Study of Chokeberry to Reduce Cardiovascular Disease Risk in Former Smokers
The purpose of this project is to determine whether chokeberry polyphenols mitigate cardiovascular disease risk in former smokers.
- Trial name
- NCT01541826
- Testing
- Chokeberry Extract, Chokeberry extract capsule, acute
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Tobacco Use
A Study to Evaluate Changes in Smokers Using Oral Tobacco-derived Nicotine Products.
The purpose of this study is to evaluate changes in exposure to selected harmful and potentially harmful constituents (HPHC) by measuring biomarkers in adult smokers who partially or completely switch from smoking cigarettes to…
- Trial name
- NCT03692078
- Testing
- OTDN product 1, OTDN product 2, Tobacco Cessation
- Where
- 2 sites in United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Altria Client Services LLC
COPD, Chronic Obstructive Pulmonary Disease
Motivational Interviewing and Air Cleaners for Smokers With COPD (MOVE COPD)
COPD is characterized by lung injury and inflammation caused by noxious particles and gases, including those emanating from cigarette smoke and air pollution.
- Trial name
- MOVE-COPD (NCT03658538)
- Testing
- Active HEPA Air Cleaner, Motivational interviewing
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Johns Hopkins University
Asthmatic Smokers, Non-asthmatic Smokers
The Effects of Montelukast on Smokers With Asthma
The purpose of this study is: 1. To compare neutrophilia, eosinophilic inflammatory markers and asthma symptom indices between smokers and non-smokers. 2.
- Trial name
- NCT00712335
- Testing
- Fluticasone Propionate, Montelukast, Salmeterol
- Where
- South Korea
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Inje University
Positron Emission Tomography
Brain Nicotine Receptor Density in Veteran Smokers
Cigarette smoking is more prevalent among Veterans (27%) than the general U.S. population (21%). Smoking is common among people who use marijuana or caffeine heavily, and the use of menthol cigarettes is becoming increasingly…
- Trial name
- BNRDVS (NCT01721473)
- Testing
- positron emission tomography scan
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Lung Cancer, Smoking Cessation
PCORI-CER-1306-03385 Informed Decisions About Lung Cancer Screening
Educational research study where goal is to test educational materials that help people make informed decisions about lung cancer screening.
- Conditions
- Lung Cancer, Smoking Cessation, Tobacco Use Cessation
- Trial name
- NCT02286713
- Testing
- Patient Decision Aid, Standard Educational Information, Follow-Up Assessments: Questionnaires
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Oral Cancer, Smoking
Prevention of Oral DNA Damage by Black Raspberries
The purpose of this voluntary research study is to learn about the potential effects that black raspberry (BRB) lozenges may have on reducing the damage caused from cigarette smoke in mouth cells in adult smokers, which may be…
- Conditions
- Oral Cancer, Smoking, DNA Damage, Oxidative Stress
- Trial name
- NCT04372914
- Testing
- BRB Lozenges
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center