Clinical trials: Smoking, Tobacco
Smoking
Airway and Pulmonary Vascular Endothelial Function in Healthy Smokers: Effect of Inhaled Glucocorticosteroid Treatment
The purposes of the present proposal are to 1) compare inhaled albuterol-induced changes in airway blood flow (Qaw), and in CO and Ppas in healthy current smokers and lifetime non-smokers as an index of endothelial function in…
- Trial name
- smoker3 (NCT02141633)
- Testing
- echocardiogram plus albuterol, airway blood flow plus albuterol, Fluticasone propionate
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Miami
Tobacco Use
A Mobile App Based Cognitive Dissonance Intervention for Smoking Cessation
This research study aims to develop a cognitive dissonance-based mobile app for smoking cessation (Support2Quit) and test the efficacy of the app with 500 adult smokers who express a desire to quit smoking.
- Trial name
- Support2Quit (NCT05797155)
- Testing
- Support2Quit App - Cognitive Dissonance Based Smoking Cessation + Smoking Cessation Tips, Tips for Smoking Cessation App
- Where
- United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Tobacco
Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation
The purpose of this vanguard trial is to test whether clients of Sun Life are willing to join in a quit smoking program that offers counselling and tobacco cessation products to all participants over a 12-month period.
- Trial name
- CanQuit RCT (NCT06832085)
- Testing
- Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge), Cytisine, Varenicline (Champix)
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Healthy Volunteers
The Impact of Intravenous Bendavia™ on Endothelial Reactivity Dysfunction in Cigarette Smoking
This will be a phase 1 randomized, double-blind, 2-period, 2-sequence crossover trial enrolling 6 healthy volunteers to assess the impact of IV-administered Bendavia on the endothelial dysfunction induced by a single cigarette.
- Trial name
- NCT01518985
- Testing
- Bendavia, Sterile saline (0.9%), Cigarette smoking
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Mighty Therapeutics, Inc.
Smoking Cessation
Novel Treatments to Enhance Smoking Cessation Before Cancer Surgery: Effects on Smoking and Surgical Outcomes
Eligible participants will be randomized to either: 1) standard care (i.e., 4 counseling sessions and nicotine replacement therapy (NRT)) or 2) standard care + contingency management (i.e., 4 counseling sessions and NRT + 3x/week…
- Trial name
- NCT01479998
- Testing
- standard care, standard care plus contingency management
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Smokers
Study to Evaluate the Efficacy, Safety, Tolerability and Immunogenicity of 100µg NIC002 Vaccine in Cigarette Smokers Who Are Motivated to Quit Smoking.
This study is designed to determine the efficacy of high nicotine-specific antibody titers in smoking cessation.
- Trial name
- NCT00736047
- Testing
- NIC002
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Novartis
Obesity, Smoking
Africa and Middle East Cardiovascular Epidemiological Study
This is a cross-sectional, epidemiological study to determine the prevalence of cardiovascular risk factors such as obesity, smoking, dyslipidemia, diabetes mellitus and hypertension in patients attending General Practice clinics…
- Conditions
- Obesity, Smoking, Dyslipidemia, Diabetes Mellitus
- Trial name
- ACE (NCT01243138)
- Where
- 73 sites in Algeria, Cameroon and 12 more
- Volunteers
- 4,386 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Smoking, Motivational Interviewing
The Effect of Motivational Interviewing Technique on Smoking Urge and Smoking Cessation Success in Teachers
Background: Smoking, which remains one of the biggest public health threats that the world faces and has reached epidemic proportions, continues to cause more than eight million deaths on average per year worldwide.
- Conditions
- Smoking, Motivational Interviewing, School Health, Nursing
- Trial name
- NCT05374707
- Testing
- MOTIVATIONAL INTERVIEWING
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Smoking, Bipolar Disorder
Web-Delivered Acceptance & Commitment Therapy for Smokers With Bipolar Disorder
This purpose of the study is to develop and test a new website to help people who have bipolar disorder quit smoking.
- Trial name
- WebQuit Plus (NCT02750904)
- Testing
- Experimental plus Nicotine Replacement Therapy, Control plus Nicotine Replacement Therapy
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Fred Hutchinson Cancer Center
Smoking, Alcohol Drinking
Tailored Inhibitory Control Training to Reverse EA-linked Deficits in Mid-life
Insufficient inhibitory control is one pathway through which early adversity is related to a range of problems including excessive alcohol use, tobacco use, and unhealthy eating.
- Conditions
- Smoking, Alcohol Drinking, Prescription Drug Abuse, Substance-Related Disorders
- Trial name
- REV (NCT02945371)
- Testing
- Person-centered inhibitory control training, Active behavioral response training
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Smoking
Cell Phone-Based Expert Systems for Smoking Cessation
This project aims to enhance the emotional and physical well-being of veterans through the reduction of smoking by utilizing a web-based, computerized tailored intervention (CTI) with feedback messages delivered via cell phone.
- Trial name
- TXT (NCT01454999)
- Testing
- CTI
- Where
- United States
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
Smoking
E-cigarettes as a Harm Reduction Strategy
E-cigarettes have emerged as an effective strategy for replacing cigarettes among smokers from the general population, but there is a dearth of studies investigating their utility in replacing cigarettes among smokers with opioid…
- Trial name
- NCT06277271
- Testing
- E-cigarette
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Tobacco Dependence, Schizophrenia
The Pharmacogenetic Study , Readiness to Change, and Pharmacological Intervention for Smoking Cessation in Schizophrenia
Cigarette smoking represents a major health problem for patients suffering from schizophrenia. Compared to the general population, schizophrenic patients are significantly more likely to be addicted to nicotine.
- Trial name
- PSIAARP (NCT00495352)
- Testing
- Hihg-doseNRT, Low-dose NRT, bupropion
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- Yu-Li Hospital
Cigarette Smoking
Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence
The purpose of the study is to learn more about tobacco dependence and nicotine metabolism in African-Americans and whites, by studying to see if how fast a person metabolizes nicotine (how the body breaks down nicotine into…
- Trial name
- NMR (NCT01627392)
- Testing
- Smoking abstinence
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
E-Cig Use
The Impact of Chronic E-Cigarette Usage on Microvascular Health
The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds.
- Trial name
- NCT06860698
- Testing
- E-cig use
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Psychiatric Disorders
TORCH - Transdiagnostic Observation of Risk Factors, Craving and Health Behaviours in Psychiatric Patients
Mental disorders are often accompanied by health-risk behaviours, psychiatric comorbidity, and reduced functioning. TORCH investigates transdiagnostic mechanisms underlying multiple health behaviour change in adult psychiatric…
- Trial name
- TORCH (NCT07844798)
- Testing
- person-centred interventions
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Tobacco Use
NYCHA Mindfulness-based Smoking Cessation Intervention
The study will assess feasibility, accessibility and impact of a mindfulness-based smoking cessation group intervention for New York City Housing Authority (NYCHA) residents. Residents who smoke to receive an 8-week intervention.
- Trial name
- NCT04334187
- Testing
- Mindfulness Based addition treatment
- Sponsor
- NYU Langone Health
Smoking
Effect of Different Centrifuge Values on Saliva High Sensitive C-Reactive Protein (Hs-CRP) Levels in Individuals With Different Smoking Amounts
The purpose of this study; In periodontally healthy individuals, high sensitive c-reactive protein (hs-CRP) levels of non-smokers, smokers of less than 10 cigarettes per day and smokers of more than 10 cigarettes per day were…
- Trial name
- NCT06561971
- Testing
- saliva obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Smoking Cessation, Respiratory Disease
The ESTxENDS Trial- Substudy on the Effects of Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig) on Respiratory Symptoms
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Respiratory symptoms outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT03632421)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- 5 sites in Switzerland
- Volunteers
- 1,246 people, healthy volunteers welcome
- Sponsor
- University of Bern
Second Hand Tobacco Smoke, Tobacco Smoking
Air Quality Feedback to Reduce Second-hand Smoke (SHS) Exposure in the Home
This is a European study which is part of a larger research project (The TackSHS project) funded by the European Union's Horizon 2020 Research and Innovation Programme (Grant Agreement No 681040) and led by the Catalan Institute…
- Conditions
- Second Hand Tobacco Smoke, Tobacco Smoking, Tobacco Use
- Trial name
- TackSHSWP4 (NCT03151421)
- Testing
- Home air quality monitoring and feedback
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
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