Clinical trials: Smoking, Tobacco
Cigarette Smoking
Use and Harm Exposure in New Low Nicotine Cigarettes
The proposed research extends previous research on Quest® cigarette smoking behavior by testing whether compensatory smoking occurs as cigarette nicotine level decreases, and whether, as a result, biomarkers of harm exposure…
- Trial name
- NCT01202942
- Testing
- Quest
- Where
- United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine
This study will evaluate the effects of a reward devaluation strategy, which has been researched in the past, combined/augmented with the medication d-cycloserine in assisting smokers to switch from combustible cigarette (CC) to…
- Trial name
- NCT05994703
- Testing
- d-cycloserine, Juul e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Mental and Behavioral Disorders, Withdrawal State
Effect of the Electronic Cigarette on Withdrawal Symptoms
Study rationale: Sensory/behavioural elements of smoking play a role in smoking behaviour and may have a potential to assist smoking cessation.
- Trial name
- ECIG24 (NCT01454362)
- Testing
- Nicotine
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Tobacco Dependence
System Based Tracking and Treatment for Emergency Patients Who Smoke: STTEPS
Emergency Departments (EDs) are a critical component of the U.S. healthcare system, treating over 119 million patients each year.
- Trial name
- STTEPS (NCT01839903)
- Testing
- EDIS, Care as usual
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- The Miriam Hospital
Smoking
An Internet-based Dialectical Behaviour Therapy-informed Skills Training for Promoting Smoking Cessation and Improving Psychological Distress of Adult Smokers.
1. To determine the feasibility, acceptability, and preliminary effects of an internet-based DBT-ST for promoting smoking abstinence/reduction and improving psychological distress/emotional regulation in adult smokers 2.
- Trial name
- NCT06575673
- Testing
- Internet-based dialectical behaviour therapy-informed skills training, Monthly health education
- Where
- 2 sites in Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Smoking Cessation
Pager-Assisted Smoking Cessation Treatment
The proposed study tests the efficacy of using pager-assisted messages combined with nicotine patches in facilitating smoking cessation and relapse prevention in a 2-arm randomized clinical trial.
- Trial name
- Pager (NCT01207310)
- Testing
- smoking cessation counseling, Nicotine patch, alphanumeric pager
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Recession, Gingival, Tissue Grafts
Topical Hyaluronic Acid Adjunctive Effects on Healing After Free Gingival Grafting in Smokers and Non-Smokers
Comparison of the healing of free gingival grafts applied to smokers and non-smokers and evaluation of the effect of hyaluronic acid gel on healing of the donor site.
- Trial name
- NCT07143760
- Testing
- Gengigel
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Smoking
Effects of Sulforaphane (SFN) on Immune Response to Live Attenuated Influenza Virus in Smokers and Nonsmokers
Vegetables such as broccoli, cauliflower, kale and cabbage are particularly rich in a plant chemical called sulforaphane (SFN) which boosts production of certain "defense" enzymes that increase the activity of antioxidants.
- Trial name
- NCT01269723
- Testing
- Broccoli sprout homogenate, Alfalfa sprout homogenate
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Smoking, Smoking Cessation
Preventing Relapse Following Involuntary Smoking Abstinence
The prevalence of tobacco use in the military is too high. This study is designed to take advantage of the 8.5 weeks of forced tobacco cessation during Basic Military Training and develop effective interventions to prevent…
- Trial name
- AFV (NCT01374724)
- Testing
- Tobacco Use Ban, Tailored Pamphlet, Informational Pamphlet
- Where
- 2 sites in United States
- Volunteers
- 23,000 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Nicotine Dependence
Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation
Randomized trial to evaluate whether zonisamide can enhance varenicline-induced smoking cessation.
- Trial name
- 1207 (NCT01685996)
- Testing
- zonisamide
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Johns Hopkins University
Blood Pressure, High, Cardiovascular Risk Factor
Efficacy of a Brief Intervention on Reduction of Systolic Blood Pressure
This study examines the efficacy of individualized counseling letters to reduce systolic blood pressure level of ≥ 130 mmHg in individuals aged between 40 and 65 years.
- Trial name
- NCT03077373
- Testing
- Counseling letter
- Where
- Germany
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Smoking Cessation
Video Messages for Smoking Cessation Campaign
240 adult smokers will be recruited. Subjects will be asked to view video messages that encourage smoking cessation. The effect of these videos will be assessed.
- Trial name
- NCT06284369
- Testing
- Developing, Evaluating and Testing Video Messages for a Smoking Cessation Campaign, Health Message Framing
- Sponsor
- Loma Linda University
Smoking (Tobacco) Addiction
Addiction and Behavior Related to Menthol Cigarette Substitutes
The goal of the proposed study is to examine the abuse liability and substitutability of plausible menthol cigarette alternatives currently on the market, including menthol filtered little cigars (mFLC), menthol roll-your-own…
- Trial name
- MENTHOL (NCT04844762)
- Testing
- Menthol cigarettes substitutes, Usual brand menthol cigarettes and substitutes, Menthol cigarettes substitutes and menthol cigarettes
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking Cessation
Mobile Smoking Treatment for Spanish-speaking Latinx Smokers
The specific aims of the project are to develop and test a Spanish language, mobile app for smoking cessation called Impacto.
- Trial name
- NCT04417075
- Testing
- Impacto (Mobile App), Dejar de Fumar Asistente (Mobile App)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Houston
Smoking Cessation
Alaska Native Family-Based, Financial Incentives Intervention for Smoking Cessation
The objective of the proposed study is to develop and beta-test a culturally adapted, Alaska Native family-based incentives intervention for smoking cessation.
- Trial name
- Aniqsaaq (NCT05413265)
- Testing
- Phases 1 and 2
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic
Smoking Behavior, Smoking Lapse Behavior
Efficacy and Safety of NicVAX® Co-administered With Varenicline (Champix®)
The purpose of this study is to evaluate the efficacy and safety of NicVAX co-administered with varenicline as an aid in smoking cessation over a one-year period in smokers who want to quit smoking.
- Conditions
- Smoking Behavior, Smoking Lapse Behavior, Smoking Relapse Behavior
- Trial name
- NCT00995033
- Testing
- NicVAX vaccine, Varenicline
- Where
- 2 sites in Netherlands
- Volunteers
- 558 people
- Sponsor
- Maastricht University Medical Center
Multiple Sclerosis
The Effect of Cigarette Smoke on Sleep Quality and Physical Activity in People With Multiple Sclerosis
Current evidence suggests that cigarette smoke increases disease progression in people with multiple sclerosis (PwMS) and worsen their symptoms. 70% of PwMS report sleep disturbances that negatively affects their quality of life.
- Trial name
- Smoke-MS (NCT05046535)
- Testing
- Sleep quality and physical activity, Nicotine dependence, Nicotine and cotinine serum levels
- Where
- Jordan
- Volunteers
- 72 people
- Sponsor
- University of Jordan
Smoking, COPD
Canadian Cohort on the Origin and Progression of Airway Disease: Physiology Platform
The Canadian Respiratory Research Network (CRRN) has recently been established to study the origins and evolution of airways disease in the population.
- Trial name
- NCT02153684
- Where
- 3 sites in Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Nicotine Addiction, Smoking Cessation
Evaluation of a Smoking Cessation Program for Long-Term Abstinence
This observational study evaluates a structured smoking cessation program delivered via weekly group sessions. The primary objective is to assess participant-reported smoking abstinence following completion of the program and at…
- Trial name
- ESCaPe (NCT06746025)
- Testing
- Quit Center cessation program
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- Quit Center LLC
Smoking
Using Group Commitment for Smoking Cessation
This study proposes a novel behavioral intervention to help smokers in Thailand to achieve their goals of quitting. Smoking treatment programs are rare throughout most of Asia and unlikely to meet the impending demand for…
- Trial name
- NCT01311115
- Testing
- Group commitment contract, Smoking cessation education and counseling
- Where
- Thailand
- Volunteers
- 201 people
- Sponsor
- University of California, Berkeley
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