Clinical trials: Smoking, Tobacco
Smoking, Tobacco Smoking
Pilot Study of Contingency Management for Smoking Cessation
The purpose of this study is to see whether contingency management (CM) can be successfully added as an adjunct treatment to standard stop smoking services in outpatients undergoing treatment for opiate addiction.
- Conditions
- Smoking, Tobacco Smoking, Smoking, Tobacco, Smoking Cessation
- Trial name
- NCT03015597
- Testing
- Contingency Management
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College London
Smoking Cessation
Understanding Disparities in Quitting in African American and White Smokers
The purpose of this study is to describe the differences in quitting smoking between African Americans (AA) and White smokers treated with varenicline.
- Trial name
- NCT01836276
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 449 people
- Sponsor
- Nikki Nollen, PhD, MA
Smoking, Tobacco Use
Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior
Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt).
- Trial name
- NCT05572671
- Testing
- Laboratory task modeling smoking lapse behavior
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Penn State University
Chronic Pain, Tobacco Use
Opioids, Low Nicotine Cigarettes, and Chronic Pain
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain…
- Conditions
- Chronic Pain, Tobacco Use, Opioid Substitution Treatment
- Trial name
- NCT06747871
- Testing
- Very Low Nicotine Cigarettes (VLNC), Normal Nicotine Cigarettes (NNC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Tobacco Use Disorder, Smoking Cessation
Deep rTMS and Varenicline for Smoking Cessation
The purpose of this study is to investigate the effect of deep repetitive transcranial magnetic stimulation (rTMS) using the insula H-coil on smoking outcomes in smokers receiving varenicline.
- Trial name
- NCT04083144
- Testing
- Deep Repetitive Transcranial Magnetic Stimulation (Active), Varenicline
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation, Genetic Predisposition
Efficacy of the Use of Genetic Markers in the Choice of the Pharmacological Treatment of Smoking (GENTSMOKING)
Smoking is the leading cause of avoidable death in the world. Smoking is associated with the development of cardiovascular and respiratory diseases, as well as being considered a leading cause of cancer death.
- Trial name
- GENTSMOKING (NCT03362099)
- Testing
- Varenicline Tartrate or bupropion
- Where
- Brazil
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Smoking Cessation
Real-time Smoking Cessation Instant Messaging Support Using a Large Language Model (LLM)-Based Chatbot Via "Quit to Win" 2025 (QTW2025)
The goal of this trial is to learn if chatbot-based instant messaging works to help smoking cessation in general adult smokers. It will also learn about the experience, attitude, and perception of using an LLM-based chatbot.
- Trial name
- NCT06914492
- Testing
- AWARD advice, Brief leaflet on health warning and smoking cessation, Referral card
- Where
- Hong Kong
- Volunteers
- 1,058 people
- Sponsor
- The University of Hong Kong
Peri-Implant Health, Peri Implant Mucositis
Impact of Smoking on Immune Responses in Peri-implant Health and Disease
Peri-implant diseases are inflammatory conditions affecting the gums and bone around dental implants. Peri-implant mucositis causes inflammation in the gums, while peri-implantitis can also lead to bone loss and, in severe cases…
- Conditions
- Peri-Implant Health, Peri Implant Mucositis, Peri-implantitis
- Trial name
- NCT07750171
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Gazi University
Breast Cancer Survivors
Cognition in Older Breast Cancer Survivors: Treatment Exposure, APOE and Smoking History
In this study,the investigators are looking to see how older women who are survivors of breast cancer and either did or did not receive chemotherapy are affected by treatment, compared to older women who have never had cancer.
- Trial name
- NCT02122107
- Where
- 2 sites in United States
- Volunteers
- 499 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Tobacco Dependence
Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study
Specific aims: 1. To obtain pilot data on 4-week continuous quit rates associated with 10 weeks of treatment with topiramate or placebo or topiramate plus nicotine patch for smoking cessation. 2.
- Trial name
- NCT00755716
- Testing
- Topiramate, Nicotine patch
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- UConn Health
Smoking
Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation
The goal of this study is to evaluate the effects of a smoking cessation intervention combining behavioral treatment with low nicotine cigarettes on neuroimaging measures of reward function and smoking cessation outcomes.
- Trial name
- NCT02927847
- Testing
- Nicotine Patch, SPECTRUM Nicotine Research Cigarettes (.03 mg), Behavioral Activation
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Maggie M Sweitzer, PhD
Tobacco Dependence
Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes
Project 1, Study 1 will evaluate the relationship between nicotine yield of very low nicotine content cigarettes and cigarettes smoked per day, nicotine exposure, discomfort/dysfunction, other health-related behaviors…
- Trial name
- P1S1 (NCT01681875)
- Testing
- very low nicotine content cigarettes
- Where
- 9 sites in United States
- Volunteers
- 839 people
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia, Major Depressive Disorder
Influence of rTMS on Symptoms and Cognitive Function in Patients With Psychiatric Disorders
The investigators investigated the effects of high frequency (10Hz) repetitive transcranial magnetic stimulation (rTMS) on the symptoms and cognitive functioning in patients with psychiatric disorders
- Trial name
- NCT04055181
- Testing
- rTMS in schizophrenia Controls, rTMS in schizophrenia patients, rTMS in major depressive disorders controls
- Where
- 6 sites in China
- Volunteers
- 800 people
- Sponsor
- Beijing HuiLongGuan Hospital
Hypertension, Diabetes
A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti
Investigators will establish a longitudinal cohort of ~3,000 adults >18 years in Port-au-Prince using multistage random sampling, and follow them longitudinally to evaluate the prevalence and incidence of cardiovascular disease…
- Conditions
- Hypertension, Diabetes, Obesity, Kidney Diseases
- Trial name
- NCT03892265
- Testing
- Observational Study
- Where
- Haiti
- Volunteers
- 3,005 people
- Sponsor
- Weill Medical College of Cornell University
Obesity, Smoking Cessation
Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
The purpose of this research study is to develop and pilot a multiple health behavior change intervention for weight loss and smoking cessation using medication (Naltrexone + Bupropion) and behavior therapy in adults seeking…
- Conditions
- Obesity, Smoking Cessation, Bariatric Surgery Patients
- Trial name
- NCT07224087
- Testing
- Naltrexone Hydrochloride, Bupropion HCl Extended Release, Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Efficacy of Financial Incentives
Voucher Based Incentives to Treat Pregnant Smokers
The major goal of this project is to examine the efficacy of a voucher-based incentive program for promoting smoking cessation (Study 1) and preventing relapse (Study 2) during pregnancy and postpartum.
- Trial name
- NCT01801384
- Testing
- Voucher-based incentives
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- University of Vermont
Healthy, Non-Smoking
Evaluation of Varenicline Safety, Tolerability, Pharmacokinetics and Pro-Cognitive Effects in Healthy Elderly Non-Smoking Subjects
1. Characterize the tolerability and safety of repeated doses of varenicline in healthy non-smoking elderly subjects. 2. Describe the steady state pharmacokinetics of varenicline in healthy non-smoking elderly subjects. 3.
- Trial name
- NCT00694044
- Testing
- varenicline
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tobacco Use Disorder
Evaluation of a Combined Parent-student Programme for Smoking Prevention in Berlin Schools
The purpose of this study is to evaluate the effectiveness of a combined parent-student program for smoking prevention in 7th graders in Berlin schools.
- Trial name
- BEST (NCT01306552)
- Testing
- Student-Intervention only group, Multi-component Intervention, Control Group
- Where
- Germany
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Smoking, Smoking Behaviors
CSD190601: A Study to Determine Subject Puffing Patterns of Electronic Nicotine Delivery Systems in an Ambulatory Setting
This study will be a single-center, controlled, open-label, parallel two-study-group investigation to evaluate the puffing patterns of healthy adult consumers of tobacco products switching from a usual brand (UB) Electronic…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04308434
- Testing
- CSD190601-11, CSD190601-12, CSD190601-13
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Cannabis Use, Tobacco Use
Effect of Cannabis on E-Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT06609109
- Testing
- THC High Dose, THC Low Dose, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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