Clinical trials: Smoking, Tobacco
Smoking
Efficacy and Safety Study of Nicotine Mint Lozenge (2mg and 4mg) in Smoking Cessation
A multi-center, randomized, double-blind, placebo-controlled, 4-arm clinical study to evaluate efficacy and safety of nicotine lozenge (2mg and 4mg) in smoking cessation in adult cigarette smokers who are motivated to quit…
- Trial name
- NCT00985985
- Testing
- Nicotine
- Volunteers
- 723 people
- Sponsor
- GlaxoSmithKline
Alcohol Drinking, Smoking
An Effectiveness Trial of Project ALERT
The purpose of this study is to replicate a longitudinal evaluation of Project ALERT, a substance abuse prevention program that targets middle school students.
- Conditions
- Alcohol Drinking, Smoking, Marijuana Smoking
- Trial name
- NCT00650585
- Testing
- Project ALERT
- Where
- United States
- Volunteers
- 8,338 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Tobacco, Tobacco Abstinence
Quitting Matters Human Immunodeficiency Virus Hybrid Trial
The purpose of this study is to compare the advantages and disadvantages of two approaches for quitting smoking among people living with HIV (PWH).
- Conditions
- Tobacco, Tobacco Abstinence, Smoking Cessation, Smoking Cessation; Tobacco Dependence
- Trial name
- QMH (NCT06883097)
- Testing
- Learn to Quit-HIV (LTQ-H) App, QuitStart
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- Wake Forest University Health Sciences
Smoking, Tobacco Use
IQOS (Non-Cigarette Tobacco Product) Pilot Study
A novel type of non-cigarette tobacco product was recently approved for sale in the US, the heated tobacco product (HTP) IQOS. IQOS may be less harmful than cigarettes, and there are some reports that it may produce more…
- Trial name
- NCT04357379
- Testing
- IQOS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Tobacco Smoking
Computer Tailored Program for Smoking Cessation Among Romanian Adults
The research aim is the development, implementation and evaluation of the first computer tailored smoking cessation progam for Romanian adult smokers. It will be implemented among smokers from Romania aged 20-60 years.
- Trial name
- NCT02028962
- Testing
- Lifestyle counseling
- Where
- Romania
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Smoking
Low Dose Computed Tomography for Lung Cancer Screening
This study will evaluate the impact of a proactive, EHR-supported enrollment strategy that links LDCT-eligible smokers with an evidence-based intervention comprised of a web-based program and integrated text messaging.
- Trial name
- LDCT (NCT03084835)
- Testing
- Usual Care, WEB+TXT, WEB+TXT+TTS
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease (COPD)
Smoking Cessation in Patients With COPD (SMOCC) in General Practice
Background: Smoking cessation is the key element in the treatment of patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- SMOCC (NCT00628225)
- Testing
- Counseling and Nicotine replacement (CN), Counseling, Nicotine replacement and Bupropion (CNB)
- Where
- Netherlands
- Volunteers
- 667 people
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Nicotine Vaping, Nicotine Dependence
Nicotine and Pavlovian Bias
Nicotine remains a major cause of health problems in the US and around the world. Insight into the behavioral changes induced by nicotine use may help advance the understanding of the mechanisms underlying the maintenance of…
- Trial name
- NCT06027723
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Acute Coronary Syndrome, Tobacco Use
Post Acute Cardiac Event Smoking (PACES) Study
Summary of the Project : Quitting smoking following acute coronary syndrome (ACS) can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and…
- Trial name
- NCT03413423
- Testing
- BAT-CS, Smoking Cessation and Health & Wellness
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- Hennepin Healthcare Research Institute
Endothelial Function, Platelet Aggregation
Effect of Passive Smoking on Platelet Function and Endothelial Function
Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood.
- Trial name
- NCT00923988
- Testing
- secondhand smoke exposure
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Graubünden
Smoking
Smoking Cessation Assistance With LIBERTAL, A Phospholipid Mixture
It has been shown in rodent models that chronic substance abuse is associated with a rigidification of cell membrane fluidity due to a change in the membrane cholesterol/phospholipids ratio.
- Trial name
- NCT00317213
- Testing
- LIBERTAL- a phospholipid mixture
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Kaplan Medical Center
Smoking Cessation, Smoking Behaviors
Varenicline Light Smoking Pilot
The goal of this study is to assess varenicline vs. placebo for its effect on decreasing cue reactivity in light and intermittent smokers.
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking
- Trial name
- NCT04089982
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Glucagon-like Peptide-1, Smoking Cessation
Smoking Cessation Facilitated by Glucagon-like Peptide-1 (GLP-1) Analogues
Cigarette smoking is the leading preventable cause of premature death worldwide. However smoking is a very difficult addiction to break whereby main reasons for not quitting or relapsing after cessation are the nicotine…
- Conditions
- Glucagon-like Peptide-1, Smoking Cessation, Weight Change, Body, Craving
- Trial name
- SKIP (NCT03204396)
- Testing
- Dulaglutide, 0.5 ml normal saline (0.9% sodium chloride [0.9% NaCl])
- Where
- Switzerland
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cancer of Head and Neck
Discontinuation of Tobacco Dependence in Smoking Patients With Squamous Cell Carcinoma of the Head-neck District: Multicenter Prospective Observational Study
The primary objective of our study is to evaluate the effectiveness of a standardized clinical practice counseling strategy for promoting post-diagnosis smoking cessation among patients with SCCHN.
- Trial name
- STOP-HNC (NCT06995417)
- Testing
- Smoking counseling
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Smoking
Brief Intervention to Promote Smoking Cessation in DM Smokers
The study is a randomized controlled trial (RCT) on a tailored smoking cessation intervention targeted type 2 diabetic patients who smoke (DM intervention). The objectives are: 1.
- Trial name
- NCT02875782
- Testing
- Smoking cessation and DM specific component intervention, Control group
- Volunteers
- 557 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Smoking Cessation
Investigating Novel Smoking Cessation Primary Care Interventions in Rural Environments
The purpose of this research study is to evaluate an electronic visit (e-visit) for smoking cessation across rural primary care settings.
- Trial name
- INSPIRE (NCT05764759)
- Testing
- Smoking cessation e-visit, Treatment as usual
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking
Antibody and Safety Study of 6 Doses of NicVAX in Smokers
Prior clinical trials examined several schedules of a nicotine vaccine (NicVAX) for anti-nicotine antibody responses, and their impact on helping smokers quit.
- Trial name
- NCT00598325
- Testing
- 3'-aminomethyl-Nic r-EPA Conjugate (NicVAX®)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Nabi Biopharmaceuticals
Tobacco Dependence
S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence
Cigarette smoking is of great public health importance and is the single most important preventable cause of morbidity, mortality and excess health care costs in the United States.
- Trial name
- NCT00722124
- Testing
- S-Adenosyl-L-Methionine
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Non-Small Cell Carcinoma, Head and Neck Squamous Cell Carcinoma
Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use
This trial studies how well an enhanced tobacco intervention protocol (ETIP) works compared to standard treatment in helping head and neck and lung cancer patients starting treatment to reduce cigarette use.
- Trial name
- NCT04694846
- Testing
- Nicotine Replacement, Bupropion Hydrochloride Controlled-release, Varenicline
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Thomas Jefferson University
Tobacco Dependence
Improving Health for Aboriginal People Through Tobacco Related Research
Aim: To identify barriers and facilitators in the uptake of smoking cessation pharmacotherapies, tobacco prevention, doctor visits, smoking amongst youth, community held health priorities and barriers to research in Aboriginal…
- Trial name
- NCT01735448
- Testing
- Focus group, One-on-one interviews, Survey
- Where
- 3 sites in Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Queen Elizabeth Hospital
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