Clinical trials: Smoking, Tobacco
Tobacco Smoking
Methods Project 4: Clinical Trial - Amended
Cigarette smokers will be randomized to E-cigarette, Nicotine Gum or Lozenge, or Control Group. Participants will enter a 1 week sampling phase.
- Trial name
- COMET (NCT03111537)
- Testing
- Cigarettes, E-Cigarette, Nicotine Gum or Lozenge
- Where
- 3 sites in United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Hookah Smoking
Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function
The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in…
- Trial name
- NCT03616002
- Testing
- Hookah smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Smoking Cessation
Post Marketing Surveillance Study of Champix in Smoking Cessation for Filipino Patients
The primary objective of this Post-Marketing Study is to monitor the safety of a novel smoking cessation drug Varenicline (Champix™) 0.5 mg and 1 mg tablets as used in clinical practice for 12 weeks among Filipino smokers.
- Trial name
- NCT00794365
- Testing
- Varenicline
- Volunteers
- 330 people
- Sponsor
- Pfizer
Smoking Cessation, Oxidative Stress
ESTxENDS Trial- Substudy on Oxidative Stress Induced by Electronic Nicotine Delivery Systems (ENDS) Measured in EBC
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Oxidative stress outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT03612453)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- Switzerland
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Bern
Smoking, Tobacco, Mental Illness
Proactive Outreach for Smoking Treatment
Tobacco use disorder is a chronic disease. This is particularly true for people living with mental illness, who are more likely to smoke and make more unsuccessful quit attempts than those without.
- Trial name
- POST (NCT04988477)
- Testing
- Study 3: Chronic care management, Study 2: Pilot trial
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Sandra Japuntich
Chronic Obstructive Pulmonary Disease, Lung Diseases, Obstructive
Impact of Multidisciplinary Care, Structured and Targeted on the COPD Patient's Clinical Pathway.
In 2020, chronic obstructive pulmonary disease (COPD) was the 4th leading cause of death worldwide. In France, its annual cost was estimated at 4366 euros per patient, including 25% related to management of exacerbations and 33%…
- Conditions
- Chronic Obstructive Pulmonary Disease, Lung Diseases, Obstructive, Lung Disease Chronic
- Trial name
- OPTI-BPCO (NCT07907601)
- Testing
- COPD targeted pharmaceutical interview and consultation, Respiratory Insufficiency Day Hospitalization, Pulmonary Function Test
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Healthy Participant
Different Modes of Universal Adhesive in Smokers and Non-Smokers
The aim of the study was to evaluate the influence of smoking on the clinical performance of a universal adhesive used with different application modes in non-carious cervical lesions.
- Trial name
- NCT04807465
- Testing
- G-Premio Bond in etch&rinse mode, G-Premio Bond in selective-etch mode, G-Premio Bond in self-etch mode
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Acute Lung Injury, Pulmonary Injury
Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury
This is an observational - data and specimen collection study. There have been increasing reports of vaping-induced lung injury, including severe lung injury and rare cases of death.
- Conditions
- Acute Lung Injury, Pulmonary Injury, Electronic Cigarette Use, Electronic Cigarette Related Lung Injury
- Trial name
- ENDALI (NCT05316727)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Health Risk Behaviors, Tobacco Smoking
Efficacy of the Proactive Automatized Lifestyle Intervention
Background: Individual brief behavior change interventions often do not sufficiently address the common co-occurrence of multiple health risk behaviors among people.
- Conditions
- Health Risk Behaviors, Tobacco Smoking, Alcohol Use, Unhealthy Diet, Exercise, Smoking, and Alcohol Use
- Trial name
- ePAL (NCT07441603)
- Testing
- Proactive Automatized Lifestyle intervention
- Where
- Germany
- Volunteers
- 788 people
- Sponsor
- University Medicine Greifswald
Tobacco Dependence
Comparative Pharmacokinetic Study of New Oral Nicotine Replacement Therapy Products.
Comparative pharmacokinetic study of new oral nicotine replacement therapy products.
- Trial name
- NCT01227720
- Testing
- Experimental Nicotine Replacement Therapy (NRT) 2 mg, Experimental Nicotine Replacement Therapy (NRT), Marketed Nicotine Lozenge
- Where
- 2 sites in Sweden
- Volunteers
- 104 people
- Sponsor
- McNeil AB
Smoking
Checking Smoking Status as a Routine Vital Sign: A Cluster-Randomized Trial of Its Effect on Cessation Counseling
The purpose of this study is to determine if checking smoking status as a routine vital sign increases the delivery rate of cessation counseling to adult smokers in primary care practices.
- Trial name
- NCT00245323
- Testing
- Smoking status as a routine vital sign
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Virginia Commonwealth University
Smoking
Exercise to Enhance Smoking Cessation for Women at the YMCA
Approximately 21% of women continue to smoke cigarettes despite the increased risk of cancer and cardiovascular disease associated with cigarette smoking.
- Trial name
- NCT01615380
- Testing
- CBT+ Contact, CBT+ Exercise
- Where
- United States
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Erectile Dysfunction, Smoking
A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers
Smokers are at higher risk of developing Erectile dysfunction (ED) independent of age and comorbidities. Sildenafil is a cytochrome p3A4 (CYP3A4) substrate used for enhancing the erectile function in males.
- Conditions
- Erectile Dysfunction, Smoking, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT04100759
- Testing
- Sildenafil 50 mg Oral Tablet
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Nicotine Dependence
Testing an Organizational Change Model to Address Smoking in Mental Healthcare
Despite an overall reduction in US smoking rates from >50% in the 1960s to about 20% by 2000, the rate of smoking among persons with a serious mental illness (SMI) remains 2-3 times greater than in the general population.
- Trial name
- NCT02849652
- Testing
- ATTOC Intervention, UC Intervention
- Where
- United States
- Volunteers
- 832 people
- Sponsor
- University of Pennsylvania
Healthy Volunteers
The Impact of Intravenous Bendavia™ on Endothelial Reactivity Dysfunction in Cigarette Smoking
This will be a phase 1 randomized, double-blind, 2-period, 2-sequence crossover trial enrolling 6 healthy volunteers to assess the impact of IV-administered Bendavia on the endothelial dysfunction induced by a single cigarette.
- Trial name
- NCT01518985
- Testing
- Bendavia, Sterile saline (0.9%), Cigarette smoking
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Mighty Therapeutics, Inc.
Nicotine Labeling for E-cigarettes
Survey to Test the Nicotine Concentration and Nicotine Flux Labels for E-cigarettes
Current labels for the nicotine in e-cigarette/vaping products do not sufficiently convey information to the public. The aims of this study include developing and validating two new types of labels for the nicotine in vaping…
- Trial name
- NCT07553585
- Testing
- Updated Labeling
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Yale University
Cigarillo Smoking
Cigarillo Public Education Messaging for Black Young Adults
This is a 3-arm randomized controlled trial to examine the effects of cigarillo public education messages among Black young adults who are at-risk for established cigarillo smoking.
- Trial name
- NCT06863168
- Testing
- Cigarillo Health Harm and Nicotine Addiction Messaging, Cigarillo Health Harm and Nicotine Addiction Messaging Contextualized to Outcome Expectancies
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Drexel University
Smoking Cessation; Tobacco Dependence
Characterization of Smoking Habits Patterns in Medical Doctors of a Central Hospital in Portugal - What Has Changed After 15 Years? A Comparative Cross-sectional Study
Abstract: Tobacco dependence remains one of the primary health care concerns worldwide. Attitude of healthcare professionals towards smoking is crucial for any long-term prevention and smoking cessation program.
- Trial name
- NCT02913989
- Testing
- Smoking habits characterization
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Lisboa Ocidental
Periodontitis
Effects of Smoking and Vitamin D3 on the Levels of Human Cathelicidin Peptide LL-37
The aims of our study were 1) to evaluate levels of gingival crevicular fluid( GCF) human cathelicidin peptide LL-37 and serum vitamin D3 in smoker and non-smoker patients with chronic periodontitis(CP) 2) to determine whether…
- Trial name
- NCT03923218
- Testing
- LL-37 levels in Gingival crevicular fluid, Serum Vitamin D3 levels, Clinical parameters
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Smoking Cessation
Urban and Reservation Implementation of All Nations Breath of Life
This is an implementation trial of the All Nations Breath of Life (ANBL) smoking cessation program, which has already been tested for efficacy in reservation populations and shown feasibility in urban populations.
- Trial name
- ANBL-I (NCT04931810)
- Testing
- All Nations Breath of Life
- Where
- United States
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Lehigh University
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