Clinical trials: Smoking, Tobacco
Nicotine Dependence
Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse Prevention
The purpose of this research study is to find out if an investigational drug, GSK598809 can help people who have very recently quit smoking; the investigators want to find out if continuing to take GSK598809 over six weeks can…
- Trial name
- NCT01188967
- Testing
- GSK598809
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Massachusetts General Hospital
Smoking, Smoking Behaviors
Abuse Liability for Eight Electronic Nicotine Products
This will be a randomized, open-label, 8-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07323511
- Testing
- Product A, Product B, Product C
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
COPD, Asthma
Health Effects of Secondhand Smoke Exposure in Outdoor Smoking Areas in Patients With COPD and Asthma ( TackSHSWP5 )
Within the TackSHS project (H2020 project grant agreement No 681040), we will conduct a clinical research study, aiming at: i) to measure respiratory health effects when exposed to secondhand smoke (SHS) in patients with asthma…
- Conditions
- COPD, Asthma, Second Hand Tobacco Smoke
- Trial name
- TackSHSWP5 (NCT03074734)
- Testing
- Exposure to secondhand tobacco smoke
- Volunteers
- 60 people
- Sponsor
- Institut Català d'Oncologia
Healthy
Trandolapril 4 mg Tablet Under Fasting Conditions
The objective of this study is to compare the rate and extent of absorption of trandolapril from a test formulation of Trandolapril 4 mg Tablets versus the reference Mavik® 4 mg Tablets under fasting conditions.
- Trial name
- NCT00840632
- Testing
- Trandolapril 4 mg Tablets, Mavik® 4 mg Tablets
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Smoking Cessation
Quitxt Mobile Text Messaging Cessation Research Study
The health benefits of smoking cessation by age 30 are much greater than cessation later in life, including gaining 10 years of life, compared with those who continue to smoke.
- Trial name
- NCT05958667
- Testing
- Quitxt text messaging or Chat, Usual care
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Smoking Cessation
Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening
To compare the effectiveness of four interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among underserved smokers referred for lung cancer screening at four large U.S. health systems.
- Trial name
- NCT04798664
- Testing
- Removal of Financial Barriers, Financial Incentives, Mobile Health Application
- Where
- 5 sites in United States
- Volunteers
- 3,228 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Adolescent Substance Use
Guiding Good Choices for Health
This study evaluates the feasibility and effectiveness of implementing Guiding Good Choices (GGC), an anticipatory guidance curriculum for parents of early adolescents, in three large, integrated healthcare systems.
- Trial name
- GGC4H (NCT04040153)
- Testing
- Guiding Good Choices
- Where
- 3 sites in United States
- Volunteers
- 3,636 people, healthy volunteers welcome
- Sponsor
- University of Washington
Tobacco Use Disorder
Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness
Seventy to eighty percent of Veterans experiencing homelessness (VEH) smoke, which is four times the rate of the U.S. population and 2.5 times higher than among impoverished Americans.
- Trial name
- New HART (NCT07714200)
- Testing
- Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation
A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo for Smoking Cessation
The primary purpose of this study is to evaluate the safety and efficacy of varenicline given for a twelve week treatment period in comparison with placebo for smoking cessation.
- Trial name
- NCT00141167
- Testing
- varenicline
- Where
- 10 sites in South Korea, Taiwan
- Volunteers
- 250 people
- Sponsor
- Pfizer
Sex, Cigarette Smoking
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers
The proposed study evaluated sex differences in glutamate (Glu), with a focus on the dorsal anterior cingulate cortex (dACC), anterior insula, and thalamus, as well as how it is influenced by sex (males vs.
- Trial name
- NCT05279053
- Testing
- Abstinence and Smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
Open-Label, Placebo-Controlled, Parallel Group Study in Healthy Volunteers to Evaluate the Effects of Two Single MT 400 or Naproxen Sodium Tablets
This is an open-label, parallel group, single-center study. The study design consists of a screening and a treatment period. A total of 42 (approximately 21 of each sex) non-smoking healthy volunteers aged 18 - 35.
- Trial name
- NCT00596245
- Testing
- MT400
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Smoking
Ginglival Health Among Smokers Visiting Dental Hospital
The effect of different forms of nicotine intake on the gingival health of dental patients that visited a public sector in Islamabad.
- Trial name
- NCT06424600
- Testing
- Gingival Index
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
COPD (Chronic Obstructive Pulmonary Disease)
RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative
The study hypothesis is that symptomatic current and former smokers with spirometric values within the normal range (post-bronchodilator FEV1/FVC≥0.70 and post-BD FVC ≥ 70% predicted will still derive symptomatic benefit from…
- Trial name
- RETHINC (NCT02867761)
- Testing
- Indacaterol/Glycopyrrolate
- Where
- 16 sites in United States
- Volunteers
- 780 people
- Sponsor
- University of Michigan
Vaping
A Virtual Reality Vaping Prevention Intervention for Adolescents
This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school…
- Trial name
- NCT07362069
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Cigarette Smoking, Nicotine Dependence
Reducing Tobacco Use Disparities Among Low-Income Adults
Most smokers, especially those who are poor, do not receive smoking cessation treatment during their healthcare visits. This study is evaluating a novel population health management intervention for low-income smokers.
- Trial name
- NCT03077737
- Testing
- Choose to Change, Enhanced usual care
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Smoking Cessation, Tobacco Use Disorder
Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the effects of cytisinicline on the neural substrates of cigarette cue…
- Trial name
- Cytisinicline (NCT06617312)
- Testing
- Cytisinicline
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of California, Los Angeles
Tobacco Use Cessation
Effectiveness of a Chat Bot for Smoking Cessation: a Pragmatic Trial in Primary Care.
This study aims to evaluate the effectiveness of an intervention to help people to quit smoking throughout an chat bot compared with usual assistance to increase long-term rates of nicotine abstinence in smoking outpatients with…
- Trial name
- Dej@lo (NCT03445507)
- Testing
- Chat bot, Usual care
- Where
- Spain
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- Gerencia de Atención Primaria, Madrid
Tinnitus, Chronic Subjective Tinnitus
Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus
This study tests whether a single dose of nicotine gum changes brain responses to sounds and the ability to detect target sounds in non-smoking adults with chronic tinnitus.
- Trial name
- NCT07877701
- Testing
- Nicotine polacrilex gum 4 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Xianhui Wang
PONV
Effect of Combination Dexmedetomidine Added to Fentanyl-based Intravenous Patient-controlled Analgesia on Nausea Vomiting in Highly Susceptible Patients Undergoing Lumbar Spinal Surgery: Prospective Double Blinded Randomized Controlled Trial
The aim of this study is to test the hypothesis that addition of dexmedetomidine to fentanyl-based intravenous patient controlled analgesia (PCA) reduces requirement of fentanyl bolus and consequent postoperative nausea and…
- Trial name
- NCT01840254
- Testing
- dexmedetomidine, normal saline
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Yonsei University
Nicotine Dependence
Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt
Study of varenicline 2.0 mg/day treatment for 2 weeks with smoking test done in laboratory on Day 8 and a 1 week quit attempt from Day 8-14.
- Trial name
- VarenSmoke (NCT00571805)
- Testing
- varencline
- Where
- United States
- Sponsor
- NYU Langone Health
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