Clinical trials: Smoking, Tobacco
Asthma, Copd
Effects of Smoking on Bronchial Epithelium
Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases affecting millions of people worldwide.
- Trial name
- NCT00849433
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Smoking Cessation
Disease Management for Smoking Cessation
The primary aim of this study is to assess the effectiveness of both high and low intensity, disease management programs for smoking.
- Trial name
- NCT00440115
- Testing
- High intensity disease management, Low intensity disease management, Comparison group
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Basaloid Squamous Cell Carcinoma, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer
This phase II/III trial studies how well a reduced dose of radiation therapy works with nivolumab compared to cisplatin in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer that is early in its…
- Conditions
- Basaloid Squamous Cell Carcinoma, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT03952585
- Testing
- Biopsy Procedure, Biospecimen Collection, Cisplatin
- Where
- 494 sites in United States, Canada
- Volunteers
- 384 people
- Sponsor
- National Cancer Institute (NCI)
Age-Related Lung Function Decline
Ongoing Lung Decline With Age Intensified Response
This Phase II, randomized, double-blind, placebo-controlled pilot study will evaluate the effects of fisetin, a senolytic flavonoid compound, on lung function and biomarkers of cellular senescence in older adults aged 60 years…
- Trial name
- OLD AIR (NCT07676435)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Bladder Cancer, Urothelial Carcinoma
Bladder Cancer Screening Trial
There is currently no accepted screening strategy for patients at high risk of developing bladder cancer. This study will ask patients to complete a urine test every 6 months for 2 years to help assess if routine screening helps…
- Conditions
- Bladder Cancer, Urothelial Carcinoma, Hematuria, Smoking Cessation
- Trial name
- NCT05646485
- Testing
- Urinalysis
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Smoking
TeleQuit Smoking Cessation Program
TeleQuit is a group randomized trial testing whether a telephone care coordination program increases the rate of smoking cessation treatment for VA patients at study sites.
- Trial name
- NCT00123682
- Testing
- Proactive outreach to counseling, Reactive outreach to counseling, Intensive counseling
- Where
- 3 sites in United States
- Volunteers
- 3,120 people
- Sponsor
- US Department of Veterans Affairs
Behavior, Health Risk, Implementation Science
Incentive-based and Media Literacy Informed Approaches to Improve Vaping Cessation
This study aims to evaluate the feasibility and compare the preliminary effect of vaping cessation program consisting of media literacy education and real-time text messaging support and leverage insights from behavioral…
- Conditions
- Behavior, Health Risk, Implementation Science, E Cigarette Use, Cessation, Smoking
- Trial name
- NCT05586308
- Testing
- Text-massaging suport, Financial incentive, Media literacy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Nebraska
Tobacco
The Abuse Liability of IQOS Heated Tobacco Products Among Adults Who Smoke
This clinical trial aims to evaluate user sensory experiences and smoking behavior when using IQOS heated tobacco products (HTPs) among adults who smoke cigarettes.
- Trial name
- NCT07688304
- Testing
- Smoking Behavioral Research (IQOS), Smoking Behavioral Research (UBC)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Cigarette Smoking
Testing the Impact of Smartphone-based Messaging to Support Young Adult Smoking Cessation - Pilot
Clinical practice guidelines for smoking cessation emphasize cognitive behavioral therapy (CBT) to help patients develop coping strategies for urges.
- Trial name
- NCT05991934
- Testing
- Smartphone-based intervention messages
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Nicotine Dependence
Study Two on the Effectiveness of Mindfulness Training for Smokers
The MTS2 study enrollment goal is N=240 adult smokers randomized to study treatments. The study design includes two randomized arms to compare matched intensive interventions and a third non-randomized option for participants who…
- Trial name
- MTS2 (NCT01299909)
- Testing
- Integrated Training for Smokers, Mindfulness Training for Smokers, Quitline
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Wisconsin, Madison
Minority Smokers
Tobacco-Focused Patient Navigation to Address Barriers to Utilization of Community-Based Smoking Cessation Services in Primary Care
Patient navigators have been shown to assist people seeking cancer screening and other medical services. The purpose of this study is to see whether a patient navigator can link smokers to available community resources shown to…
- Trial name
- NCT01678118
- Testing
- Patient Navigator
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Smoking Cessation
Using a General Health Promotion Approach to Help Smokers With Chronic Diseases Quit
This study aims to evaluate the effectiveness of a general health promotion (GHP) approach to motivate smokers with chronic diseases to quit smoking.
- Trial name
- NCT04037696
- Testing
- General Health Promotion Approach, Control
- Where
- Hong Kong
- Volunteers
- 720 people
- Sponsor
- The University of Hong Kong
Smoking
E-cigarette vs. Nicotine Inhaler Comparisons
The goal of this study is to get information from current smokers about how they feel towards both the electronic cigarette (e-cigarette) and the nicotine oral inhaler.
- Trial name
- NCT02294617
- Testing
- Electronic Cigarette, Nicotrol Inhaler
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Obstructive Sleep Apnea, Tobacco Use
Influence of Tobacco Smoking on the Development of Obstructive Sleep Apnea (OSA)
The aim of this study was to retrospectively evaluate the influence of Tobacco Smoking on the development of Obstructive Sleep Apnea (OSA).
- Trial name
- NCT03574740
- Testing
- Tobacco Smoking
- Volunteers
- 1,298 people
- Sponsor
- Astes
Smoking Behavior
A Novel Dialectical Behavior Therapy Brief Group Intervention for Cigarette Smoking by Patients With Cancer: An Open Clinical Trial
The purpose of this research study is to learn more about how Dialectical Behavior Therapy - Skills Training can help patients with cancer who smoke cigarettes cut down on or stop their smoking.
- Trial name
- NCT07119489
- Testing
- Dialectical Behavior Therapy -Skill Training brief intervention
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Wake Forest University Health Sciences
Cannabis
Laboratory Smoking of Marijuana "Blunts"
This is a double-blind within-subjects clinical laboratory study comparing the product appeal and abuse liability-related subjective effects of different flavored cigar wrappers for marijuana blunts.
- Trial name
- NCT03546790
- Testing
- Marijuana
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Battelle Memorial Institute
Smoking, Stress Disorders, Post-Traumatic
CPT-SMART for Treatment of PTSD and Cigarette Smoking
Smoking is the leading cause of preventable illness, disability, and death in the United States. The rate of smoking is disproportionately higher among Veterans with posttraumatic stress disorder (PTSD).
- Trial name
- CPT-SMART (NCT03978442)
- Testing
- Smoking Cessation Cognitive Behavioral Therapy (CBT), Bupropion, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- VA Office of Research and Development
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation
LLM Intervention for Tobacco in Underserved Populations (LIFT-UP)
This study will test a tailored, multilingual tobacco cessation chatbot called LIFT-UP (LLM Intervention for Tobacco in Underserved Populations), designed to better meet the needs of people living in persistent poverty census…
- Trial name
- LIFT-UP (NCT07620301)
- Testing
- LIFT-UP Chatbot
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah
Smoking
CSD170501: Study to Assess Biomarkers of Tobacco Exposure in Smokers During In-Clinic Confinement Switch to an Electronic Cigarette
The purpose of this clinical study is to evaluate changes in biomarkers of exposure (BOE) to tobacco smoke constituents after smokers switch from combustible cigarettes to use of one of the three electronic cigarettes or…
- Trial name
- NCT03170674
- Testing
- FT21039, FT21092, FT21018
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
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