Clinical trials: Smoking, completed
Smoking Behaviors, Periodontal Health
Effects of E-Cigarette Use on Oxidative Stress and Matrix Degradation
This cross-sectional observational study aims to investigate the effects of e-cigarette use on oxidative and matrix-degrading pathways in periodontally healthy individuals.
- Trial name
- ECIG-FOXO (NCT07338318)
- Testing
- E-Cigarette Use
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Oral Cavity Cancer
Risk Factors Contributing to Oral Cancer in Patients at Dr. Hasan Sadikin General Hospital Bandung
Analytical research with a cross-sectional approach was carried out on patients diagnosed with oral cavity cancer who visited our outpatient clinic in Bandung between 2023 and 2024.
- Trial name
- NCT06690918
- Where
- Indonesia
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Asthma, Smoking
Determinants of Corticosteroid Insensitivity in Smokers With Asthma
Smokers with asthma display a relative insensitivity to inhaled and oral corticosteroids. The causes of this phenomenon are currently unknown.
- Conditions
- Asthma, Smoking, Steroid Resistance, Corticosteroid Insensitivity
- Trial name
- NCT00411320
- Testing
- oral steroid-dexamethasone
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- University of Glasgow
Smoking
Effectiveness of Intervention on Reducing the Prevalence of Smoking Among Adolescents
In this multicenter cluster randomized controlled trial stratified by school baseline prevalence of smoking will be randomly allocated to the control or intervention group.
- Trial name
- ITACA (NCT01602796)
- Testing
- School intervention
- Where
- 20 sites in Spain
- Volunteers
- 2,226 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Peripheral Artery Disease, Amputation
Digital Ankle Brachial Index (ABI) as a Screening Tool in Detecting Peripheral Arterial Disease
Peripheral artery disease (PAD) affects 8-18 million in the US and is an economic burden, currently estimated to be greater than cancer and heart disease.
- Conditions
- Peripheral Artery Disease, Amputation, Smoking, Diabetes
- Trial name
- NCT03161327
- Testing
- ABI using QuantaFlo™
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Cancer, Lung, Respiratory Disease
Yorkshire Enhanced Stop Smoking Study
Lung cancer rates are higher in Yorkshire than the rest of the UK, and this is due to higher rates of smoking. Deaths from lung cancer can be reduced using regular lung scans (screening) and by helping people stop smoking.
- Conditions
- Cancer, Lung, Respiratory Disease, Heart Diseases
- Trial name
- YESS (NCT03750110)
- Testing
- Intervention, Usual Care
- Where
- United Kingdom
- Volunteers
- 1,001 people
- Sponsor
- University of Nottingham
Smoking Cessation
Message Priming and Enrollment in, and Response to, a Smoking Cessation Program: A Pilot Study
The proposed study has been designed to examine the effect of a message that primes genetic susceptibility on actual enrollment in a smoking cessation program, actual response to smoking cessation treatment, and potential…
- Trial name
- NCT00596882
- Testing
- Message Prime
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Smoking Cessation
Exercise or Relaxation for Smoking Cessation
This research study is being done to find out if adding a moderate exercise program or a relaxation program to a smoking cessation treatment program will improve smoking cessation and health in postmenopausal women.
- Trial name
- NCT00921388
- Testing
- Varenicline and smoking cessation counseling, Exercise or relaxation treatment
- Where
- 2 sites in United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- UConn Health
Secondhand Exposure, Smoking Status
An Integrated Intervention to Reduce Secondhandsmoke in Children
This is a community essay to assess the effectiveness of a multi-level (individual, family, and school) school-based intervention to prevent the exposure to secondhand smoke (SHS) in a population of 1,734 schoolchildren (12-14…
- Trial name
- RESPIR·NET (NCT01881607)
- Testing
- RESPIRNET Program
- Where
- Spain
- Volunteers
- 1,779 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
COPD, Chronic Bronchitis
The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis
Specific Aim: To determine the effectiveness of Roflumilast in improving i) whole right lung and ii) peripheral right lung mucociliary clearance (MCC) in patients with COPD and chronic bronchitis.
- Conditions
- COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT03073798
- Testing
- Roflumilast
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Tobacco Use, Smoking Cessation
A Guided Imagery Tobacco Cessation Intervention Delivered by a Quit Line and Website
Tobacco use is still the leading cause of preventable disease and death in the United States. Tobacco quit lines are effective at helping smokers to quit, but quit lines are underutilized, especially by men and racial/ethnic…
- Conditions
- Tobacco Use, Smoking Cessation, Smoking, Tobacco, Tobacco Smoking
- Trial name
- QLImagery (NCT02968381)
- Testing
- Imagery Intervention, Control Condition
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Smoking
A Study of the Efficacy and Safety of Varenicline in Japanese Smokers Motivated to Quit Smoking
The purpose of this study is to evaluate the efficacy and safety of varenicline in Japanese smokers. Efficacy is evaluated by continuous quit rate and withdrawal symptoms of smokers.
- Trial name
- NCT00635401
- Testing
- Varenicline
- Where
- 8 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Pfizer
Smoking Cessation
Alaska Native Family-Based, Financial Incentives Intervention for Smoking Cessation
The objective of the proposed study is to develop and beta-test a culturally adapted, Alaska Native family-based incentives intervention for smoking cessation.
- Trial name
- Aniqsaaq (NCT05413265)
- Testing
- Phases 1 and 2
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic
Bipolar Disorder
A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder
The purpose of this pilot study is to determine the safety and potential efficacy of sustained-release bupropion (Zyban®) for the treatment of nicotine dependence in patients with bipolar affective illness.
- Trial name
- NCT00593099
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation
Real-time Smoking Cessation Instant Messaging Support Using a Large Language Model (LLM)-Based Chatbot Via "Quit to Win" 2025 (QTW2025)
The goal of this trial is to learn if chatbot-based instant messaging works to help smoking cessation in general adult smokers. It will also learn about the experience, attitude, and perception of using an LLM-based chatbot.
- Trial name
- NCT06914492
- Testing
- AWARD advice, Brief leaflet on health warning and smoking cessation, Referral card
- Where
- Hong Kong
- Volunteers
- 1,058 people
- Sponsor
- The University of Hong Kong
Tobacco Use Disorder
Smoking Cessation Treatment for Substance Use Dependents
The present research project aims to develop an innovative and empirically validated intervention protocol for smoking cessation among patients with substance use disorders (SUDs).
- Trial name
- NCT03551704
- Testing
- CBT + EFT, CBT + EFT + CM
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Oviedo
Smoking
Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum
The purpose of this study is to measure plasma nicotine uptake parameters, physiological measures, and subjective effect measures in smokers during and following a single ad libitum use of three menthol electronic cigarettes…
- Trial name
- NCT02664012
- Testing
- Own Brand Menthol Cigarette, Electronic Menthol Cigarette #1, Electronic Menthol Cigarette #2
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Vapor Company
Smoking
Cell Phone-Based Expert Systems for Smoking Cessation
This project aims to enhance the emotional and physical well-being of veterans through the reduction of smoking by utilizing a web-based, computerized tailored intervention (CTI) with feedback messages delivered via cell phone.
- Trial name
- TXT (NCT01454999)
- Testing
- CTI
- Where
- United States
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
Tobacco, Posttraumatic Stress Disorder
Improving Functional Outcomes of Veterans With PTSD and Tobacco Dependence
Veterans with PTSD have high rates of smoking (34%-86% vs. 18% in the general population) and have substantial difficulties with quitting tobacco.
- Trial name
- ACT-PT (NCT02576899)
- Testing
- Acceptance and Commitment Therapy for PTSD and Tobacco Use, Freedom From Smoking
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Tobacco Smoking
Testing the Decoy Effect to Increase Tobacco Treatment Uptake
Prior research has shown that the context in which program options are presented to consumer impacts consumer choice (known as the 'decoy effect').
- Trial name
- NCT04200157
- Testing
- Online survey
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- NYU Langone Health