Clinical trials: Smoking (Tobacco) Addiction
Nicotine Addiction
Nicotinic Receptor Levels After Stopping Smoking
This positron emission tomography (PET) study examines the effects of 24 hours abstinence from smoking on return to availability of neuronal nicotinic receptors in slow and fast metabolizers of nicotine.
- Trial name
- NCT01704573
- Testing
- 2-[18F]-fluro-3-[2(S)-2-azethidinylmethoxy]-pyridine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation
The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers.
- Trial name
- NCT05726045
- Testing
- Standard smoking cessation program (SCP), Cognitive remediation treatment (CRT), High-intensity interval training (HIIT evening)
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Nicotine Dependence
Doctors' Perspective on Tobacco Addiction
ABSTRACT Aim: Our study aimed to determine the approaches of our physicians to the smoking habits of their patients other than those with pulmonary diseases.
- Trial name
- NCT06163872
- Testing
- survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 941 people
- Sponsor
- Karadeniz Technical University
Nicotine Addiction
Nicotine Reinforcement and Aversion in Young Adult Light Smokers
The proposed study will examine the threshold for nicotine self-administration (NSA) using five different nicotine doses in young adult male and female non-dependent smokers (light and intermittent smokers or LITS).
- Trial name
- NCT01495819
- Testing
- Saline, Nicotine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Nicotine Dependence
The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence
The advent of electronic cigarette (e-cigarette) technologies represents one of the most significant developments in the last several decades, and provides a novel and promising strategy for substantially reducing the morbidity…
- Trial name
- Ecig1 (NCT02590393)
- Testing
- E-cigarettes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Nicotine Use Disorder
Neural Basis of Eating Behavior in Abstinent Smokers
The purpose of this research study is to better understand why people gain weight when they quit smoking by examining food intake and changes in brain activity in smokers when they are smoking as usual compared to when they have…
- Trial name
- SIT (NCT03438188)
- Testing
- Practice Quit Attempt
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Nicotine Withdrawal
Progesterone and Brain Imaging Study
Male and female smokers were recruited to undergo 2 phases of smoking cessation. Each phase was 4 days long and involved 3 brain-imaging scans, blood draws and an intervention involving progesterone or a matched placebo.
- Trial name
- NCT01954966
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Addiction, Smoking Related Diseases
A Photoaging Mobile App Promoting Poster Campaign for Preventing Smoking in Secondary Schools
The purpose of this study is to determine whether photoaging mobile app promoting poster campaigns are effective to reduce smoking prevalence among adolescents in Germany. This is measured via questionnaire.
- Conditions
- Tobacco Addiction, Smoking Related Diseases, Adolescent Smoking
- Trial name
- Smokerface (NCT02544360)
- Testing
- Photoaging mobile app promoting poster campaign.
- Where
- Germany
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Tobacco Addiction
Efficacy and Safety of BP1.4979 in Smoking Cessation
Clinical study which aim is to assess in heavy smokers willing to quit smoking the efficacy and the safety profile of BP1.4979 for smoking cessation on the total abstinence measured by subject diary and confirmed by exhaled CO…
- Trial name
- NCT01785147
- Testing
- BP1.4979
- Where
- France
- Volunteers
- 219 people
- Sponsor
- Bioprojet
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Cigarette Smoking, Nicotine Addiction
STOP Study: Effectiveness of Zyban in a Clinical Population
Despite the significant health, social and economic costs of cigarette smoking, 17% of Ontarians still currently smoke. Use of smoking cessation pharmacotherapy such as Zyban (bupropion HCl) has been shown to double quit rates…
- Conditions
- Cigarette Smoking, Nicotine Addiction, Smoking Cessation
- Trial name
- NCT01015170
- Testing
- bupropion HCl
- Where
- 24 sites in Canada
- Volunteers
- 454 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation, Nicotine Addiction
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation.
- Conditions
- Smoking Cessation, Nicotine Addiction, Schizophrenia
- Trial name
- NCT05276050
- Testing
- active F8-coil delivered rTMS, active H-coil delivered rTMS
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cigar Smoking, Tobacco Use
Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)
This clinical trial will recruit young adults who currently use cigarillos and examine the smoking behavior and perceptions of different flavored cigarillos, product ingredients/additives impacting these perceptions, and…
- Trial name
- CLARITY (NCT07162935)
- Testing
- Cigarillo brand 1, Cigarillo brand 2, Cigarillo brand 3
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Tobacco Addiction
Duration of Behavioral Counseling Treatment Needed to Optimize Smoking Abstinence
The purpose of this study is to determine if extending the behavioral smoking-cessation treatment period to one year will significantly improve cessation outcomes among those planning a quit attempt.
- Trial name
- EDC (NCT01038414)
- Testing
- Extended Duration Behavioral Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Harvard University Faculty of Medicine
Nicotine Use Disorder
Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.
- Trial name
- NCT05932745
- Testing
- E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yale University
Nicotine Vaping, Nicotine Dependence
Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency
Electronic nicotine delivery systems (ENDS) heat and vaporize a nicotine-containing liquid to produce an aerosol that can deliver nicotine to the blood and the brain.
- Conditions
- Nicotine Vaping, Nicotine Dependence, Nicotine Addiction
- Trial name
- NCT05430334
- Testing
- e-liquid 1, e-liquid 2, e-liquid 3
- Where
- Lebanon
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Nicotine Dependence
Combination Nicotine Patch / Lorcaserin for Smoking Cessation
This study plans to compare the efficacy of the nicotine patch / lorcaserin combination treatment vs. the nicotine patch alone in terms of leading to a reduction in smoking behavior and withdrawal symptoms.
- Trial name
- LorNic (NCT02906644)
- Testing
- lorcaserin, nicotine patch
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
Nicotine Dependence
GABA (Gamma Amino Butyric Acid) Medication for Tobacco
The goal of this study is to examine the effects of a GABA (gamma amino butyric acid)-enhancing medication, pregabalin (300 mg/day), on smoking behavior, tobacco withdrawal and cigarette craving in smokers.
- Trial name
- NCT00644137
- Testing
- pregabalin, cigarettes
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Smoking, Nicotine Dependence
Effects of Intensive Behavioral Training Program on Impulsivity and Inhibitory Control in Smokers
Dependence on tobacco derived nicotine is a major public health problem. Substance users who complete training in mindfulness subjectively report increased patience and improved motor control over their impulses.
- Conditions
- Tobacco Smoking, Nicotine Dependence, Impulsivity, Addiction
- Trial name
- IBTP (NCT01314378)
- Testing
- Mindfulness Training, Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital