Clinical trials: Smoking Addiction
Nicotine Dependence
Transcranial Direct Current Stimulation in a Smoking Cessation Trial
The purpose of this study is to determine the effectiveness of transcranial direct current stimulation (tDCS) plus nicotine patch as a viable smoking cessation program for nicotine dependent smokers.
- Trial name
- tDCS (NCT01710410)
- Testing
- active transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation
Benefit of Systematic Proposition of Nicotine Substitution for Patients Undergoing Surgery
Smoking is associated with a higher rate of surgical complications. For example, in orthopedics, the risk of complications is 31% in smokers against 5% in non-smokers.
- Trial name
- PATCHIR (NCT04572646)
- Testing
- NRT proposition and exhaled CO measurement
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Groupe Hospitalier Mutualiste de Grenoble
Nicotine Addiction
Acute and Chronic Nicotine Modulation of Reinforcement Learning
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation.
- Trial name
- NicLearning (NCT01830842)
- Testing
- Nicotine polacrilex, satiety, abstinence
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Cigarette Smoking, Nicotine Addiction
STOP Study: Effectiveness of Zyban in a Clinical Population
Despite the significant health, social and economic costs of cigarette smoking, 17% of Ontarians still currently smoke. Use of smoking cessation pharmacotherapy such as Zyban (bupropion HCl) has been shown to double quit rates…
- Conditions
- Cigarette Smoking, Nicotine Addiction, Smoking Cessation
- Trial name
- NCT01015170
- Testing
- bupropion HCl
- Where
- 24 sites in Canada
- Volunteers
- 454 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking (Tobacco) Addiction, Smoking Cessation
PeRiopEratiVE SmokiNg CessaTion Trial
PREVENT is a multicentre, 2x2 factorial, randomized clinical trial that aims to determine the effect of cytisine versus placebo, as well as the effect of video messaging to support smoking cessation versus standard of care in…
- Trial name
- PREVENT (NCT05102123)
- Testing
- Cytisine, Video Messaging
- Where
- 4 sites in Canada
- Volunteers
- 1,720 people
- Sponsor
- Population Health Research Institute
Nicotine Addiction
A Smoking Intervention Study Using Scheduled Gradual Reduction With Varenicline to Help With Cessation
This study has three main aims. Aim 1: To provide initial data on the efficacy of combined Scheduled Gradual Reduction (SGR) and Varenicline (VN) for smoking cessation, by assessing abstinence and levels of smoking at 2 time…
- Trial name
- NCT01772641
- Testing
- Scheduled Gradual Reduction + Varenicline, Basic Advice + Varenicline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Drug Addiction, Nicotine Dependence
Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray
Background: Smoking is the leading cause of preventable death in the United States, and researchers are interested in gaining a better understanding of the perceived beneficial effects of nicotine to help improve treatment…
- Trial name
- NCT01136642
- Testing
- Nicotrol
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence
The primary aim of this study is to conduct a 60-patient feasibility, acceptability, and preliminary efficacy study of mSMART (Mobile App based Personalized Solutions and Tools for Medication Adherence of Rx Pill), a smartphone…
- Trial name
- mSMART-Ib (NCT02635919)
- Testing
- mSMART
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Tobacco Addiction
Duration of Behavioral Counseling Treatment Needed to Optimize Smoking Abstinence
The purpose of this study is to determine if extending the behavioral smoking-cessation treatment period to one year will significantly improve cessation outcomes among those planning a quit attempt.
- Trial name
- EDC (NCT01038414)
- Testing
- Extended Duration Behavioral Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Harvard University Faculty of Medicine
Smoking, Smoking Behaviors
Translational Research Center in Lung Cancer Disparities (TRACER) Project 2
The purpose of this study is to examine racial differences in smoking behaviors and stress responses between African American and white male smokers.
- Conditions
- Smoking, Smoking Behaviors, Smoking Cessation, Stress Reaction
- Trial name
- TRACER (NCT05490251)
- Where
- 2 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Tobacco Use Disorder
Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation
The purpose of this study is to compare the effects of bupropion + placebo to bupropion + naltrexone as treatments to help smokers quit.
- Trial name
- NCT00419731
- Testing
- Bupropion, Bupropion + Naltrexone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cigarette Smoking, Addiction Nicotine
Investigation of Cigarette Cravings in Smokers
Interventions to disrupt memory reconsolidation have held promise for the treatment of stress- and anxiety-related disorders. In the present study, the investigators will examine whether an intervention based on these principles…
- Conditions
- Cigarette Smoking, Addiction Nicotine, Tobacco Use
- Trial name
- NCT04843969
- Testing
- Stress induction, Control stress exposure, Cue induction
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Marco Leyton
Alcohol Use Disorder (AUD), Alcoholism
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans.
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Smoking, Tobacco
- Trial name
- ReCoDe (NCT05992272)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Trier Social Stress Test
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Nicotine Use Disorder
Neural Basis of Eating Behavior in Abstinent Smokers
The purpose of this research study is to better understand why people gain weight when they quit smoking by examining food intake and changes in brain activity in smokers when they are smoking as usual compared to when they have…
- Trial name
- SIT (NCT03438188)
- Testing
- Practice Quit Attempt
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1
Currently one in five high school students smokes. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158171
- Testing
- Nicotine Replacement Therapies, Nicotine patch, Folic Acid
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence, Opiate Dependence
Developing a Smoking Cessation Intervention for Methadone Maintained Smokers
The purpose of this study is to pilot and evaluate, in a randomized controlled trial, the immediate and long-term effects of a newly developed, tailored, intensive smoking cessation intervention among methadone maintained smokers…
- Trial name
- NCT01393392
- Testing
- Intensive, tailored intervention, NJ Quitline Referral
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Addiction
Nicotinic Receptor Levels After Stopping Smoking
This positron emission tomography (PET) study examines the effects of 24 hours abstinence from smoking on return to availability of neuronal nicotinic receptors in slow and fast metabolizers of nicotine.
- Trial name
- NCT01704573
- Testing
- 2-[18F]-fluro-3-[2(S)-2-azethidinylmethoxy]-pyridine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Cocaine Withdrawal, Cocaine Smoking
Use of Intranasal Oxytocin During Detoxification of Crack Cocaine
This study investigated whether adding oxytocin nasal spray to usual inpatient treatment could reduce withdrawal, anxiety, and depressive symptoms in women hospitalized for cocaine detoxification.
- Conditions
- Cocaine Withdrawal, Cocaine Smoking, Cocaine-Related Disorders
- Trial name
- NCT04306354
- Testing
- Oxytocin nasal spray, Conventional Inpatient Treatment
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Nicotine Addiction
Effects of ABT-089 on Smoking Abstinence Symptoms and Reward
This Phase IIa within-subject, cross-over pilot study will evaluate the effects of ABT-089 (an experimental medication not approved by the FDA) when administered as 40mg oral once daily dose for 10 days, compared to placebo, on…
- Trial name
- NCT01756053
- Testing
- ABT-089
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pennsylvania
Smoking Cessation, Cancer, Treatment-Related
Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment
Smoking cessation has been shown to improve the effectiveness and reduce the morbidity of tobacco-related cancer treatments. We will identify effective smoking cessation strategies for patients who are receiving treatment for…
- Trial name
- TTOP (NCT04634071)
- Testing
- Varenicline, Bupropion, Long-acting nicotine replacement therapy
- Where
- 3 sites in United States
- Volunteers
- 126 people
- Sponsor
- Joseph Valentino, MD