Clinical trials: Smoking Addiction
Nicotine Dependence, Cigarettes
The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products
This study plans to investigate whether using electronic cigarettes (e-cigarettes) or skin patches containing nicotine affects switching from smoking conventional combustible (burning) cigarettes.
- Trial name
- ENDS-Switch (NCT03492463)
- Testing
- Nicotine patch, E-cigarettes, Non-nicotine e-cigarettes
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Duke University
Tobacco Addiction
Efficacy and Safety of BP1.4979 in Smoking Cessation
Clinical study which aim is to assess in heavy smokers willing to quit smoking the efficacy and the safety profile of BP1.4979 for smoking cessation on the total abstinence measured by subject diary and confirmed by exhaled CO…
- Trial name
- NCT01785147
- Testing
- BP1.4979
- Where
- France
- Volunteers
- 219 people
- Sponsor
- Bioprojet
Nicotine Addiction
Effect of Galantamine on Smoking Abstinence
This is a preliminary open-label study to determine whether a medication called galantamine (Brand Name: Razadyne) will help smokers quit and whether it reduces cognitive problems that smokers experience during a quit attempt.
- Trial name
- NCT01548638
- Testing
- Galantamine ER
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
Nicotine Addiction, Smoking Cessation
e-Cigarettes Versus NRT Gum for Smoking Cessation
This is a randomized trial comparing electronic cigarettes (e-Cigarettes) to nicotine gum for smoking cessation. Participants will be randomly assigned to either e-cigarette use or nicotine gum use during a quit attempt.
- Trial name
- NCT01925781
- Testing
- Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Creighton University
Smoking, Smoking Cessation
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's Tobacco Treatment Program.
- Conditions
- Smoking, Smoking Cessation, Smoking Reduction, Smoking Habit
- Trial name
- NCT06693700
- Testing
- Indoor Air Quality Monitor AirGradient ONE
- Where
- 8 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreatitis, Chronic, Pancreatitis, Acute
Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis
The purpose of this research is to assess the effectiveness of two treatment strategies for smoking cessation in patients with acute recurrent pancreatitis or chronic pancreatitis who smoke cigarettes.
- Conditions
- Pancreatitis, Chronic, Pancreatitis, Acute, Recurrent Acute Pancreatitis, Smoking (Tobacco) Addiction
- Trial name
- NCT07171112
- Testing
- Standard Varenicline Dosing (1 mg BID), Bupropion 150 mg twice daily, Increased Varenicline Dosing (1mg TID)
- Where
- United States
- Sponsor
- Mayo Clinic
HIV Infections, AIDS
HIV Infection and Tobacco Use Among Injection Drug Users in Baltimore, Maryland: A Pilot Study of Biomarkers
Background: The incidence of lung cancer is quite high among people with the human immunodeficiency (HIV) virus. Frequent smoking may explain that cancer increase, given that 50% to 70% of HIV-infected people are current smokers.
- Conditions
- HIV Infections, AIDS, Lung Cancer, Tobacco Addiction
- Trial name
- NCT00491335
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Smoking
Meriter Mindfulness Training for Smokers Program and Study
The Meriter Smoking Cessation Study tests participants in the Meriter Smoking Cessation Program. Meriter Hospital and clinic patients will be recruited into the Meriter Smoking Cessation Program.
- Trial name
- NCT02143752
- Testing
- Mindfulness, Quit Line
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- University of Wisconsin, Madison
Nicotine Dependence
Transcranial Direct Current Stimulation in a Smoking Cessation Trial
The purpose of this study is to determine the effectiveness of transcranial direct current stimulation (tDCS) plus nicotine patch as a viable smoking cessation program for nicotine dependent smokers.
- Trial name
- tDCS (NCT01710410)
- Testing
- active transcranial Direct Current Stimulation
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking (Tobacco) Addiction
Addiction and Behavior Related to Menthol Cigarette Substitutes
The goal of the proposed study is to examine the abuse liability and substitutability of plausible menthol cigarette alternatives currently on the market, including menthol filtered little cigars (mFLC), menthol roll-your-own…
- Trial name
- MENTHOL (NCT04844762)
- Testing
- Menthol cigarettes substitutes, Usual brand menthol cigarettes and substitutes, Menthol cigarettes substitutes and menthol cigarettes
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking Cessation, Cigarette Smoking
Effects of Random Nicotine Delivery on Smoking Cessation
The objective of this study is to determine whether treatment with random nicotine delivery via a nicotine film both before and after the target quit date will facilitate smoking cessation relative to treatment with steady state…
- Conditions
- Smoking Cessation, Cigarette Smoking, Smoking (Tobacco) Addiction
- Trial name
- NCT03674970
- Testing
- Nicotine Film
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Alcohol Use Disorder (AUD), Alcoholism
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans.
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Smoking, Tobacco
- Trial name
- ReCoDe (NCT05992272)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Trier Social Stress Test
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Nicotine Dependence
Combination Nicotine Patch / Lorcaserin for Smoking Cessation
This study plans to compare the efficacy of the nicotine patch / lorcaserin combination treatment vs. the nicotine patch alone in terms of leading to a reduction in smoking behavior and withdrawal symptoms.
- Trial name
- LorNic (NCT02906644)
- Testing
- lorcaserin, nicotine patch
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
Nicotine Dependence
Stage Ib Trial of mSMART With Varenicline
The primary aim of this study is to conduct a 60-patient feasibility, acceptability, and preliminary efficacy study of mSMART (Mobile App based Personalized Solutions and Tools for Medication Adherence of Rx Pill), a smartphone…
- Trial name
- mSMART-v (NCT03069768)
- Testing
- mSMART, Chantix
- Where
- United States
- Sponsor
- Duke University
Behavioral Intervention, Nicotine Addiction
Impact of Appointment Reminder Strategies on Smoking Cessation Clinic Attendance
The goal of this clinical trial is to learn whether different appointment reminder methods can improve attendance at an anti-smoking (smoking cessation) clinic among adult smokers.
- Trial name
- NO-SHOW-NCC (NCT07779161)
- Testing
- Standard phone call, phone call with MINDSPACE elements
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Gdansk
Smoking Cessation
Effects of Smoking Addiction on Lower Limb Speed and Coordination
This observational case-control study will investigate the impact of smoking addiction on lower extremity speed and coordination in young adults.
- Trial name
- NCT07061522
- Testing
- Behavioral/Physical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Nicotine Addiction, Cigarette Smoking
Control Systems Approach to Predicting Individualized Dynamics of Nicotine Cravings
Nicotine is the most common drug of abuse in the United States, and has addiction strength comparable to cocaine, heroin, and alcohol.
- Trial name
- NCT02643914
- Testing
- Nicotine, MR Compatible Nicotine Delivery Device
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Smoking, Cannabis
Imaging the Neurochemistry of Drug Addiction With PET
The investigators' project has two overarching goals. 1) The investigators will use newly developed positron emission tomography (PET) technology to investigate the dopaminergic neurochemistry of drugs of abuse including…
- Trial name
- NCT02817698
- Testing
- cannabis
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Cigarette Smoking, Addiction Nicotine
Investigation of Cigarette Cravings in Smokers
Interventions to disrupt memory reconsolidation have held promise for the treatment of stress- and anxiety-related disorders. In the present study, the investigators will examine whether an intervention based on these principles…
- Conditions
- Cigarette Smoking, Addiction Nicotine, Tobacco Use
- Trial name
- NCT04843969
- Testing
- Stress induction, Control stress exposure, Cue induction
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Marco Leyton
Nicotine Dependence
Doctors' Perspective on Tobacco Addiction
ABSTRACT Aim: Our study aimed to determine the approaches of our physicians to the smoking habits of their patients other than those with pulmonary diseases.
- Trial name
- NCT06163872
- Testing
- survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 941 people
- Sponsor
- Karadeniz Technical University