Clinical trials: Smoking Addiction
Nicotine Dependence
Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction
Background: Treatment for nicotine addiction is characterized by high rates of relapse. New treatment therapies for nicotine addiction are exploring the use of brain scanning equipment to control and decrease nicotine and…
- Trial name
- NCT01031693
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Tobacco, Smoking (Tobacco) Addiction
Effects of Nicotine in Tobacco Smokers
This study will examine mechanisms linking Obsessive-Compulsive Disorder symptomatology to tobacco dependence.
- Trial name
- NCT03651869
- Testing
- Cigarette 1, Cigarette 2, Patch 1
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Obesity, Smoking Cessation
Gut Hormones in Obesity, Nicotine and Alcohol Dependence
The "Gut Hormones in Addiction" study is a proof-of-concept experimental medicine human study to answer the following questions: 1.
- Conditions
- Obesity, Smoking Cessation, Alcoholism
- Trial name
- GHADD (NCT02690987)
- Testing
- Exenatide, Desacyl ghrelin, Saline
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Smoking Cessation, Nicotine Addiction
Circuitry-Guided Smoking Cessation in Schizophrenia
In a double-blinded, randomized, parallel controlled design, patients with schizophrenia spectrum disorder will be exposed to active or sham repetitive transcranial magentic stimulation (TMS) which was guided by functional…
- Conditions
- Smoking Cessation, Nicotine Addiction, Schizophrenia
- Trial name
- NCT03281629
- Testing
- Active TMS stimulation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Maryland, Baltimore
Smoking, Addiction
Evaluation of Transdermal Nicotine Replacement Therapy (NRT) Activity Through Metabolic Induction
Evaluation to determine if auto-induction can be used as a surrogate measure of nicotine receptor up-regulation through an observational study using nicotine replacement therapy for two weeks and no intervention for two weeks.
- Trial name
- NCT01438944
- Testing
- Nicabate 21mg transdermal NRT
- Where
- Australia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Queen Elizabeth Hospital
Psychology, Social, Smoking Cessation
Mindset Intervention for Nicotine Dependence
This study evaluates a new digitally delivered mindset based intervention in addition to a smartphone application (app) for smoking cessation.
- Conditions
- Psychology, Social, Smoking Cessation, Smoking (Tobacco) Addiction
- Trial name
- MIND (NCT03174730)
- Testing
- Growth Mindset, SmartQuit
- Where
- United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Diabetes Mellitus, Type 2, Nicotine Addiction
Semaglutide for Smoking Cessation in Patients With Diabetes
To assess the feasibility of conducting a randomized controlled trial (RCT) to determine the effectiveness of semaglutide as an adjunct to combination NRT in supporting smoking cessation for patients with diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Nicotine Addiction, Tobacco Dependence
- Trial name
- GLP1-SC (NCT07059377)
- Testing
- Semaglutide, Nicotine replacement
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Nicotine Addiction, Serious Mental Illness
Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness
Quitting smoking has important health benefits for people with serious mental illness, more than half of whom are smokers. Smoking reductions in this population, in turn, could contribute to saving billions of dollars in…
- Trial name
- NCT03069482
- Testing
- Learn to Quit App, Nicotine patch, Nicotine lozenge
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Duke University
Smoking Cessation, Nicotine Addiction
Factors Sustaining Tobacco Abstinence in Cancer Patients Treated With Radio-chemotherapy or Radiotherapy
The TABAC STOP ORL POUMON study aims to evaluate the factors influencing long-term smoking cessation in patients with head and neck cancer (HNC) or lung cancer undergoing radiotherapy or chemoradiotherapy.
- Conditions
- Smoking Cessation, Nicotine Addiction, Nicotine Dependence, Smoking
- Trial name
- TABAC STOP ORL (NCT06910566)
- Testing
- Chemoradiotherapy or radiotherapy alone
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Oscar Lambret
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2
Currently one in five high school students smoke. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158158
- Testing
- Usual Care, Smoking Reduction
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder, Smoking Cessation
Deep rTMS and Varenicline for Smoking Cessation
The purpose of this study is to investigate the effect of deep repetitive transcranial magnetic stimulation (rTMS) using the insula H-coil on smoking outcomes in smokers receiving varenicline.
- Trial name
- NCT04083144
- Testing
- Deep Repetitive Transcranial Magnetic Stimulation (Active), Varenicline
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence, Transcranial Magnetic Stimulation
Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)
The goal of this clinical trial is to learn if a combination of varenicline and enhanced accelerated Transcranial Magnetic Stimulation (aTMS) works to help adults quit using nicotine products.
- Conditions
- Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation
- Trial name
- V-TMS (NCT07145866)
- Testing
- Varenicline, Transcranial Magnetic Stimulation, Nicotine Cessation Counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Tobacco Use Disorder, Nicotine Addiction
Effects of Semaglutide on Nicotine Intake
Tobacco use remains the foremost cause of preventable deaths in the U.S. and worldwide. Advancing new smoking cessation therapies, including those targeting novel biological mechanisms, is a critical public health priority.
- Trial name
- NCT05530577
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Nicotine Addiction, E-Cig Use
Sex Differences in E-cig Perception: Study 1
The primary objective is to examine the influence of sex on sensory effects, appeal, and reinforcing value of nicotine containing e-cigs in popular flavor components; sweet and cooling.
- Conditions
- Nicotine Addiction, E-Cig Use, Cigarette Smoking, Sex Differences
- Trial name
- NCT05432830
- Testing
- E-liquid Flavor 1, E-liquid Flavor 2, E-liquid Flavor 3
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use, Tobacco Use Cessation
CONNECT Cancer Survivors With Tobacco Treatment
The purpose of this study is to evaluate the comparative effectiveness of two different informatics-enabled implementation strategies on increasing tobacco treatment and improving smoking cessation rates for cancer control and…
- Conditions
- Tobacco Use, Tobacco Use Cessation, Smoking Cessation, Nicotine Addiction
- Trial name
- NCT07020273
- Testing
- ELEVATE, ELEVATE-S
- Where
- United States
- Volunteers
- 3,543 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Tobacco Use Cessation, Addiction
An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention
The Healthy Futures: Alternative-to-Suspension Curriculum is a free, online curriculum developed to educate students and provide them with resources to quit tobacco/nicotine use.
- Trial name
- NCT06483412
- Testing
- Healthy Futures: Alternative-to-Suspension Curriculum
- Where
- United States
- Volunteers
- 2,540 people, healthy volunteers welcome
- Sponsor
- Stanford University
Nicotine Dependence
Concurrent Bupropion / Varenicline for Smoking Cessation
This study focuses on the first step in developing an algorithm for maximizing quit-smoking success based on an adaptive approach, which changes treatment from the initial nicotine replacement therapy (NRT) when that treatment…
- Trial name
- ConNic4 (NCT01303861)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 4 sites in United States
- Volunteers
- 702 people
- Sponsor
- Duke University
Smoking (Tobacco) Addiction, Smoking ( Cigarette)
Measuring Communal Coping in Dual-smoking Couples Making a Quit Attempt
Smoking is the leading preventable cause of death in the United States, and quitting is especially difficult for couples who both smoke.
- Conditions
- Smoking (Tobacco) Addiction, Smoking ( Cigarette), Tobacco, Tobacco Abstinence
- Trial name
- NCT07553962
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Nicotine Addiction
A Smoking Intervention Study Using Scheduled Gradual Reduction With Varenicline to Help With Cessation
This study has three main aims. Aim 1: To provide initial data on the efficacy of combined Scheduled Gradual Reduction (SGR) and Varenicline (VN) for smoking cessation, by assessing abstinence and levels of smoking at 2 time…
- Trial name
- NCT01772641
- Testing
- Scheduled Gradual Reduction + Varenicline, Basic Advice + Varenicline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Smoking (Tobacco) Addiction, Young Adult
Designing a Smoking Intervention for Youth Smokers
This study aims to develop a typology-based intervention delivered by smoking cessation (SC) counsellors to prevent smoking relapse in ex-smokers who recently quit.
- Conditions
- Smoking (Tobacco) Addiction, Young Adult, RCT
- Trial name
- NCT07178899
- Testing
- typology-based intervention, Routine Treatment
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong